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pro vyhledávání: '"Shuji Hosoh"'
Autor:
Hitomi Yoshida, Hiroshi Tsuneki, Shuji Hosoh, Norihiko Mori, Tsutomu Wada, Toshiyasu Sasaoka, Kosuke Endo, Masaaki Tsuda
Publikováno v:
Diabetes Research and Clinical Practice. 129:62-72
Aims Centrally administered insulin improves cognitive functions in patients with Alzheimer’s disease; however, it remains unknown whether long-acting insulin analogs exert more pronounced effects than insulin. In the present study, we directly com
Autor:
Norihiko Mori, Yoshiyuki Soeda, Naoki Toyooka, Xu Wang, Shuji Hosoh, Syota Kagawa, Hiroshi Tsuneki, Toshiyasu Sasaoka, Teruko Uwano, Hayato Muranaka, Yoshinori Ichihara, Yusaku Takamura, Tsutomu Wada, Hisao Nishijo
Publikováno v:
Molecular Endocrinology. 24:1965-1977
Impairment of insulin and IGF-I signaling in the brain is one of the causes of dementia associated with diabetes mellitus and Alzheimer’s disease. However, the precise pathological processes are largely unknown. In the present study, we found that