Zobrazeno 1 - 10
of 133
pro vyhledávání: '"Shuji Mizumoto"'
Autor:
Hayato Ota, Hirokazu Sato, Shuji Mizumoto, Ken Wakai, Kei Yoneda, Kazuo Yamamoto, Hayao Nakanishi, Jun-Ichiro Ikeda, Shinichi Sakamoto, Tomohiko Ichikawa, Shuhei Yamada, Satoru Takahashi, Yuzuru Ikehara, Shoko Nishihara
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-16 (2023)
Abstract Androgen deprivation therapy is given to suppress prostate cancer growth; however, some cells continue to grow hormone-independently as castration-resistant prostate cancer (CRPC). Sulfated glycosaminoglycans promote ligand binding to recept
Externí odkaz:
https://doaj.org/article/aa8c11582cf6481ba26e4b14fd87cada
Autor:
Soichiro Saito, Shuji Mizumoto, Tsukasa Yonekura, Rina Yamashita, Kenta Nakano, Tadashi Okubo, Shuhei Yamada, Tadashi Okamura, Tatsuya Furuichi
Publikováno v:
PLoS ONE, Vol 18, Iss 4, p e0284292 (2023)
SLC35A3 is considered an uridine diphosphate N-acetylglucosamine (UDP-GlcNAc) transporter in mammals and regulates the branching of N-glycans. A missense mutation in SLC35A3 causes complex vertebral malformation (CVM) in cattle. However, the biologic
Externí odkaz:
https://doaj.org/article/37f802978ebc4c5f9b1d7095a09c706e
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Externí odkaz:
https://doaj.org/article/fd9c633ef2924b21b2c9515780e07a5c
Autor:
Yuko Nitahara-Kasahara, Shuji Mizumoto, Yukiko U. Inoue, Shota Saka, Guillermo Posadas-Herrera, Aki Nakamura-Takahashi, Yuki Takahashi, Ayana Hashimoto, Kohei Konishi, Shinji Miyata, Chiaki Masuda, Emi Matsumoto, Yasunobu Maruoka, Takahiro Yoshizawa, Toshiki Tanase, Takayoshi Inoue, Shuhei Yamada, Yoshihiro Nomura, Shin'ichi Takeda, Atsushi Watanabe, Tomoki Kosho, Takashi Okada
Publikováno v:
Disease Models & Mechanisms, Vol 14, Iss 12 (2021)
Musculocontractural Ehlers-Danlos syndrome (mcEDS) is caused by generalized depletion of dermatan sulfate (DS) due to biallelic pathogenic variants in CHST14 encoding dermatan 4-O-sulfotransferase 1 (D4ST1) (mcEDS-CHST14). Here, we generated mouse mo
Externí odkaz:
https://doaj.org/article/18ac308ec99e4737bca148fc2a47dc8c
Autor:
Shuji Mizumoto, Shuhei Yamada
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Chondroitin sulfate (CS), dermatan sulfate (DS) and heparan sulfate (HS) are covalently attached to specific core proteins to form proteoglycans in their biosynthetic pathways. They are constructed through the stepwise addition of respective monosacc
Externí odkaz:
https://doaj.org/article/ba9a7e4359fc4dcba51146d3466f6ef8
Autor:
Yuko Nitahara-Kasahara, Guillermo Posadas-Herrera, Shuji Mizumoto, Aki Nakamura-Takahashi, Yukiko U. Inoue, Takayoshi Inoue, Yoshihiro Nomura, Shin’ichi Takeda, Shuhei Yamada, Tomoki Kosho, Takashi Okada
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Carbohydrate sulfotransferase 14 (CHST14) encodes dermatan 4-O-sulfotransferase 1, a critical enzyme for dermatan sulfate (DS) biosynthesis. Musculocontractural Ehlers-Danlos syndrome (mcEDS) is associated with biallelic pathogenic variants of CHST14
Externí odkaz:
https://doaj.org/article/628c0d523aa044b4b5618df49eddeeef
Autor:
Shuji Mizumoto, Shuhei Yamada
Publikováno v:
Frontiers in Genetics, Vol 12 (2021)
Glycosaminoglycans (GAGs) including chondroitin sulfate, dermatan sulfate, and heparan sulfate are covalently attached to specific core proteins to form proteoglycans, which are distributed at the cell surface as well as in the extracellular matrix.
Externí odkaz:
https://doaj.org/article/c559530ec06d408ab21ab16d186cb922
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Glycosaminoglycans (GAGs) including chondroitin sulfate, dermatan sulfate, heparan sulfate, and keratan sulfate, except for hyaluronan that is a free polysaccharide, are covalently attached to core proteins to form proteoglycans. More than 50 gene pr
Externí odkaz:
https://doaj.org/article/3829a4a0b62341c9b5838ed4c0e44b2b
Autor:
Shuhei Yamada, Shuji Mizumoto
Publikováno v:
Molecules, Vol 27, Iss 18, p 6103 (2022)
Hyaluronidases (HYALs) are endo-beta-N-acetylhexosaminidases that depolymerize not only hyaluronan but also chondroitin sulfate (CS) at the initial step of their catabolism. Although HYAL1 hydrolyzes both CS and HA, HYAL4 is a CS-specific endoglycosi
Externí odkaz:
https://doaj.org/article/5841b98fda3149f6b8766c403d3e181d
Autor:
Sarah Delbaere, Adelbert De Clercq, Shuji Mizumoto, Fredrik Noborn, Jan Willem Bek, Lien Alluyn, Charlotte Gistelinck, Delfien Syx, Phil L. Salmon, Paul J. Coucke, Göran Larson, Shuhei Yamada, Andy Willaert, Fransiska Malfait
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
Proteoglycans are structurally and functionally diverse biomacromolecules found abundantly on cell membranes and in the extracellular matrix. They consist of a core protein linked to glycosaminoglycan chains via a tetrasaccharide linkage region. Here
Externí odkaz:
https://doaj.org/article/9ae0749259af4444b51e1cf46479dc64