Zobrazeno 1 - 10
of 189
pro vyhledávání: '"Shuji, Takada"'
Publikováno v:
Cell Death and Disease, Vol 14, Iss 8, Pp 1-11 (2023)
Abstract Leucine zipper-like transcriptional regulator 1 (LZTR1), a substrate adaptor of Cullin 3 (CUL3)-based E3 ubiquitin ligase, regulates proteostasis of the RAS subfamily. Mutations in LZTR1 have been identified in patients with several types of
Externí odkaz:
https://doaj.org/article/fc4ff836fd52453686eb361b1da64f91
Autor:
Shiori Kinoshita, Kazuaki Kojima, Eriko Ohnishi, Yuka Takayama, Hiroki Kikuchi, Shuji Takada, Kazuhiko Nakabayashi, Tomoko Kawai, Kenichiro Hata
Publikováno v:
Frontiers in Genetics, Vol 15 (2024)
Background: Epigenetic disruptions have been implicated in neurodevelopmental disorders. NSD2 is associated with developmental delay/intellectual disability; however, its role in brain development and function remains unclear.Methods: We performed tr
Externí odkaz:
https://doaj.org/article/a55c640feebc490b8dbe57f06ebdad12
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract Mucopolysaccharidosis type II (MPS II) is a lysosomal storage disorder characterized by an accumulation of glycosaminoglycans (GAGs), including heparan sulfate, in the body. Major manifestations involve the central nerve system (CNS), skelet
Externí odkaz:
https://doaj.org/article/89af4d5bd2e649eeb96d5d0a32f25537
Autor:
Narutoshi Yamazaki, Mari Ohira, Shuji Takada, Akira Ohtake, Masafumi Onodera, Mahito Nakanishi, Torayuki Okuyama, Ryuichi Mashima
Publikováno v:
Molecular Genetics and Metabolism Reports, Vol 37, Iss , Pp 101021- (2023)
Mucopolysaccharidosis type II (MPS II, OMIM 309900) is an X-linked disorder caused by a deficiency of lysosomal enzyme iduronate-2-sulfatase (IDS). The clinical manifestations of MPS II involve cognitive decline, bone deformity, and visceral disorder
Externí odkaz:
https://doaj.org/article/eb24e9ce4dae491295f89c82b84acf30
Autor:
Julien Richard Albert, Toshihiro Kobayashi, Azusa Inoue, Ana Monteagudo-Sánchez, Soichiro Kumamoto, Tomoya Takashima, Asuka Miura, Mami Oikawa, Fumihito Miura, Shuji Takada, Masumi Hirabayashi, Keegan Korthauer, Kazuki Kurimoto, Maxim V. C. Greenberg, Matthew Lorincz, Hisato Kobayashi
Publikováno v:
Genome Biology, Vol 24, Iss 1, Pp 1-32 (2023)
Abstract Background Genomic imprinting affects gene expression in a parent-of-origin manner and has a profound impact on complex traits including growth and behavior. While the rat is widely used to model human pathophysiology, few imprinted genes ha
Externí odkaz:
https://doaj.org/article/d2b4346a6d9745bcb4ddefb8b94050fb
Autor:
Ryuichi Mashima, Shuji Takada
Publikováno v:
Current Issues in Molecular Biology, Vol 44, Iss 10, Pp 5013-5027 (2022)
Lipid nanoparticles (LNPs) are an emerging vehicle for gene delivery that accommodate both nucleic acid and protein. Based on the experience of therapeutic liposomes, current LNPs have been developed based on the chemistry of lipids and RNA and on th
Externí odkaz:
https://doaj.org/article/6e8162a4caba4a7eb1bedd13c6b97ce6
Autor:
Tomoyo Yoshida, Tadashi Yokoi, Taku Tanaka, Emiko Matsuzaka, Yuki Saida, Sachiko Nishina, Shuji Takada, Shigeomi Shimizu, Noriyuki Azuma
Publikováno v:
Cells, Vol 13, Iss 2, p 130 (2024)
Retinal ganglion cells (RGCs) are specialized projection neurons that constitute part of the retina, and the death of RGCs causes various eye diseases, but the mechanism of RGC death is still unclear. Here, we induced cell death in human induced plur
Externí odkaz:
https://doaj.org/article/ad7118206a69455aa8368a850ba18c70
Autor:
Miki Inoue, Takashi Baba, Fumiya Takahashi, Miho Terao, Shogo Yanai, Yuichi Shima, Daisuke Saito, Kei Sugihara, Takashi Miura, Shuji Takada, Mikita Suyama, Yasuyuki Ohkawa, Ken-ichirou Morohashi
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-14 (2022)
Investigation of fetal Leydig progenitors shows that thymosin β10 (Tmsb10) suppresses the RAS/ERK pathway, inducing progenitor differentiation into fetal Leydig cells.
Externí odkaz:
https://doaj.org/article/3bdd9960171d464396c4238431385530
Autor:
Masamichi Ito, Manami Katoh, Tatsuro Sassa, Toshiyuki Ko, Kanna Fujita, Shintaro Yamada, Koichiro Miura, Masashi Toyoda, Shuji Takada, Takashige Tobita, Mikako Katagiri, Masayuki Kubota, Takanobu Yamada, Satoshi Hatsuse, Hiroyuki Morita, Masashi Ikeuchi, Katsuhisa Matsuura, Akihiro Umezawa, Seitaro Nomura, Hiroyuki Aburatani
Publikováno v:
Circulation; 9/17/2024, Vol. 150 Issue 12, p971-974, 4p
Autor:
Miyuki SHINDO, Miho TERAO, Shuji TAKADA, Minoru ICHINOSE, Emiko MATSUZAKA, Tadashi YOKOI, Noriyuki AZUMA, Seiya MIZUNO, Hideki TSUMURA
Publikováno v:
Experimental Animals; 2024, Vol. 73 Issue 2, p203-210, 8p