Zobrazeno 1 - 10
of 99
pro vyhledávání: '"Shuiyu, Lu"'
Publikováno v:
Chemistry – A European Journal. 27:10369-10376
Effective methods are needed for labelling acyclic ureas with carbon-11 (t1/2 =20.4 min) as potential radiotracers for biomedical imaging with positron emission tomography (PET). Herein, we describe the rapid and high-yield syntheses of unsymmetrical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0f94f6acb25dae3357a7b65f9baa461f
https://doi.org/10.1002/chem.202100690
https://doi.org/10.1002/chem.202100690
Publikováno v:
Angew Chem Int Ed Engl
Herein, the synthesis and use of [11 C]carbonyl difluoride for labeling heterocycles with [11 C]carbonyl groups in high molar activity is described. A very mild single-pass gas-phase conversion of [11 C]carbon monoxide into [11 C]carbonyl difluoride
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5d645b8a47d9bedcc75849721ea6225
https://doi.org/10.1002/ange.201915414
https://doi.org/10.1002/ange.201915414
Autor:
Jeih-San Liow, Cheryl L. Morse, Shuiyu Lu, Michael Frankland, George L. Tye, Sami S. Zoghbi, Robert L. Gladding, Anver B. Shaik, Robert B. Innis, Amy H. Newman, Victor W. Pike
Publikováno v:
Molecules, Vol 23, Iss 11, p 2737 (2018)
Selective high-affinity antagonists for the dopamine D3 receptor (D3R) are sought for treating substance use disorders. Positron emission tomography (PET) with an effective D3R radioligand could be a useful tool for the development of such therapeuti
Externí odkaz:
https://doaj.org/article/678fbdb739924590a9f94c9eb0165f18
Autor:
Michael P. Frankland, Jeih-San Liow, Christer Halldin, Anton Lindberg, Yong Sok Lee, Magnus Schou, Cheryl L. Morse, Shuiyu Lu, Nahid Amini, Charles S. Elmore, Robert B. Innis, Victor W. Pike, Sami S. Zoghbi, Akihiro Takano, Sangram Nag, Robert L. Gladding
Publikováno v:
Nuclear Medicine and Biology. 70:1-13
INTRODUCTION: The serotonin 1B receptor subtype is of interest in the pathophysiology and treatment of depression, anxiety, and migraine. Over recent years 5-HT(1B) receptor binding in human brain has been examined with PET using radio ligands that a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d97953f775298a51ea40b30e4080666
https://doi.org/10.1016/j.nucmedbio.2019.01.005
https://doi.org/10.1016/j.nucmedbio.2019.01.005
Publikováno v:
Chemistry
Effective methods are needed for labelling acyclic ureas with carbon-11 (t(1/2)=20.4 min) as potential radiotracers for biomedical imaging with positron emission tomography (PET). Herein, we describe the rapid and high-yield syntheses of unsymmetrica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::83e346e33830a4ae4f01a924df65b644
https://pubmed.ncbi.nlm.nih.gov/33890705
https://pubmed.ncbi.nlm.nih.gov/33890705
Autor:
Peter J. Lindsay-Scott, Victor W. Pike, J. Craig Ruble, Maria Cuadrado, Mohammad B. Haskali, Michael P. Johnson, Susan DuBois, Nancy Kant, Hugh Nuthall, Shuiyu Lu, Jeremy Gilmore, Kevin Michael Ruley, Aneta Kowalski, Enrique Jambrina, S Michelle Morin, Adrian J. Mogg, Soumen Paul, Andrew J. Mannes, Jeih-San Liow, Vanessa N. Barth, Cheryl L. Morse, Sami S. Zoghbi, Nicolas Dreyfus, Robert L. Gladding, Cynthia Darshini Jesudason, Robert B. Innis, Sergey Shcherbinin
Publikováno v:
Science Translational Medicine. 12
We aimed to develop effective radioligands for quantifying brain O-linked-β-N-acetyl-glucosamine (O-GlcNAc) hydrolase (OGA) using positron emission tomography in living subjects as tools for evaluating drug target engagement. Posttranslational modif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2f7c374cfed67cb7447ad9f601ab0b13
https://doi.org/10.1126/scitranslmed.aau2939
https://doi.org/10.1126/scitranslmed.aau2939
Over the last half-century, the molecular imaging technique of positron emission tomography (PET) has emerged as an important tool for biomedical research, drug development and medical diagnosis. The power of PET derives from its utilization of radio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7a63a54c9a6ef7fcc2cb5d13db4b71c8
https://doi.org/10.1016/bs.aihch.2019.11.005
https://doi.org/10.1016/bs.aihch.2019.11.005
Autor:
Cheryl L. Morse, Martin Fisher, Shuiyu Lu, Sami S. Zoghbi, Robert B. Innis, Lindsay McMurray, Franklin I. Aigbirhio, Victor W. Pike, George L. Tye, Aneta Kowalski, Jeih-San Liow
Publikováno v:
ChemMedChem. 13:138-146
Cytosolic phospholipase A2α (cPLA2α) may play a critical role in neuropsychiatric and neurodegenerative disorders associated with oxidative stress and neuroinflammation. An effective PET radioligand for imaging cPLA2α in living brain might prove u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1173a01d63fa274aa007595c90697746
https://doi.org/10.1002/cmdc.201700697
https://doi.org/10.1002/cmdc.201700697
Publikováno v:
The Journal of Organic Chemistry. 82:11925-11932
Pd(0)-mediated 11C-carbonylation of aryl(mesityl)iodonium salts followed by suitable quench provides a rapid room-temperature two-pot procedure for labeling arylcarboxylic acids and amide derivatives with the short-lived positron emitter carbon-11 (t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e1877b97f44e0d1455adb6fbc0ca6fef
https://doi.org/10.1021/acs.joc.7b01704
https://doi.org/10.1021/acs.joc.7b01704
Publikováno v:
European Journal of Organic Chemistry. 2017:6593-6603
Positron emission tomography (PET) is an important molecular imaging technique for medical diagnosis, biomedical research and drug development. PET tracers for molecular imaging contain β+-emitting radionuclides, such as carbon-11 (t1/2 = 20.4 min)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::10d9f1e5b1146095daaff7f7167ef8e7
https://doi.org/10.1002/ejoc.201700970
https://doi.org/10.1002/ejoc.201700970