Zobrazeno 1 - 10
of 200
pro vyhledávání: '"Shuiying Hu"'
Autor:
Yang Li, Thomas Drabison, Mahesh Nepal, Richard H. Ho, Alix F. Leblanc, Alice A. Gibson, Yan Jin, Wenjian Yang, Kevin M. Huang, Muhammad Erfan Uddin, Mingqing Chen, Duncan F. DiGiacomo, Xihui Chen, Sobia Razzaq, Jeffrey R. Tonniges, Dana M. McTigue, Alice S. Mims, Maryam B. Lustberg, Yijia Wang, Amanda B. Hummon, William E. Evans, Sharyn D. Baker, Guido Cavaletti, Alex Sparreboom, Shuiying Hu
Publikováno v:
JCI Insight, Vol 8, Iss 14 (2023)
Vincristine is a widely used chemotherapeutic drug for the treatment of multiple malignant diseases that causes a dose-limiting peripheral neurotoxicity. There is no clinically effective preventative treatment for vincristine-induced sensory peripher
Externí odkaz:
https://doaj.org/article/ce9d6058dddc4a1f9ae29073d522d78d
Publikováno v:
Clinical and Translational Science, Vol 14, Iss 2, Pp 460-467 (2021)
Chemotherapy‐induced peripheral neuropathy (CIPN) is a common and dose‐limiting toxicity to widely used chemotherapeutics. Although the exact molecular mechanism of chemotherapy‐induced peripheral neuropathy remains elusive, there is consensus
Externí odkaz:
https://doaj.org/article/e48cd4b4288942deac1c2b135d72b811
Autor:
Daelynn R. Buelow, Jason T. Anderson, Stanley B. Pounds, Lei Shi, Jatinder K. Lamba, Shuiying Hu, Alice A. Gibson, Emily A. Goodwin, Alex Sparreboom, Sharyn D. Baker
Publikováno v:
Clinical and Translational Science, Vol 14, Iss 1, Pp 137-142 (2021)
Reduced expression of the uptake transporter, OCTN1 (SLC22A4), has been reported as a strong predictor of poor event‐free and overall survival in multiple cohorts of patients with acute myeloid leukemia (AML) receiving the cytidine nucleoside analo
Externí odkaz:
https://doaj.org/article/60a03cb38eac4e618ecd1c78891d4e02
Autor:
Sijin Guo, Mario Vieweger, Kaiming Zhang, Hongran Yin, Hongzhi Wang, Xin Li, Shanshan Li, Shuiying Hu, Alex Sparreboom, B. Mark Evers, Yizhou Dong, Wah Chiu, Peixuan Guo
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Although paclitaxel is widely used as a chemotherapy, it suffers from poor solubility and toxicity issues. Here, the authors develop thermostable RNA nanoparticles and report the RNA-paclitaxel complex to display improved stability, drug loading capa
Externí odkaz:
https://doaj.org/article/db868a87fc9b4ea6a3135743c4926948
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 8, Iss 12, Pp 931-939 (2019)
Paclitaxel is a commonly used drug in the treatment of multiple solid tumors, including cancers of the breast, lung, and ovaries. Despite the established exposure–pharmacodynamic relationships for paclitaxel, treatment is associated with wide inter
Externí odkaz:
https://doaj.org/article/5a36a64c5d2f43a4b2a53a70f6567990
Autor:
Dominique A. Garrison, Yan Jin, Zahra Talebi, Shuiying Hu, Alex Sparreboom, Sharyn D. Baker, Eric D. Eisenmann
Publikováno v:
Molecules, Vol 27, Iss 20, p 6815 (2022)
Gilteritinib, an FDA-approved tyrosine kinase inhibitor approved for the treatment of relapsed/refractory FLT3-mutated acute myeloid leukemia, is primarily eliminated via CYP3A4-mediated metabolism, a pathway that is sensitive to the co-administratio
Externí odkaz:
https://doaj.org/article/b65f1f8fc5034a02aae249f90a5b1265
Autor:
Yang Li, Yan Jin, Hanieh Taheri, Keith T. Schmidt, Alice A. Gibson, Stefan A. J. Buck, Eric D. Eisenmann, Ron H. J. Mathijssen, William D. Figg, Sharyn D. Baker, Alex Sparreboom, Shuiying Hu
Publikováno v:
Pharmaceutics, Vol 14, Iss 9, p 1933 (2022)
In recent years, various endogenous compounds have been proposed as putative biomarkers for the hepatic uptake transporters OATP1B1 and OATP1B3 that have the potential to predict transporter-mediated drug–drug interactions (DDIs). However, these co
Externí odkaz:
https://doaj.org/article/f5ac3357508f42909be4461d3b90d944
Autor:
Muhammad Erfan Uddin, Eric D. Eisenmann, Yang Li, Kevin M. Huang, Dominique A. Garrison, Zahra Talebi, Alice A. Gibson, Yan Jin, Mahesh Nepal, Ingrid M. Bonilla, Qiang Fu, Xinxin Sun, Alec Millar, Mikhail Tarasov, Christopher E. Jay, Xiaoming Cui, Heidi J. Einolf, Ryan M. Pelis, Sakima A. Smith, Przemysław B. Radwański, Douglas H. Sweet, Jörg König, Martin F. Fromm, Cynthia A. Carnes, Shuiying Hu, Alex Sparreboom
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 15, p 8607 (2022)
Dofetilide is a rapid delayed rectifier potassium current inhibitor widely used to prevent the recurrence of atrial fibrillation and flutter. The clinical use of this drug is associated with increases in QTc interval, which predispose patients to ven
Externí odkaz:
https://doaj.org/article/b8e2cb1b13fb4e639c3779666fe42092
Autor:
Qiang Fu, Mingqing Chen, Jason T. Anderson, Xinxin Sun, Shuiying Hu, Alex Sparreboom, Sharyn D. Baker
Publikováno v:
Clinical and Translational Science, Vol 12, Iss 4, Pp 400-407 (2019)
Regorafenib, a multikinase inhibitor used in the treatment of various solid tumors, undergoes extensive uridine 5′‐diphosphate glucuronosyltransferase (Ugt)1a9‐mediated glucuronidation to form regorafenib‐N‐β‐glucuronide (M7; RG), but th
Externí odkaz:
https://doaj.org/article/d129c0e299354f14a23eb6a1d1f2d7ce
Autor:
Christina D. Drenberg, Anang Shelat, Jinjun Dang, Anitria Cotton, Shelley J. Orwick, Mengyu Li, Jae Yoon Jeon, Qiang Fu, Daelynn R. Buelow, Marissa Pioso, Shuiying Hu, Hiroto Inaba, Raul C. Ribeiro, Jeffrey E. Rubnitz, Tanja A. Gruber, R. Kiplin Guy, Sharyn D. Baker
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Pediatric AML is traditionally treated with chemotherapy and stem cell transplant but some subsets of patients have a poor response to therapy. Here, the authors perform a high throughput screen and identify several FDA approved drugs that might be u
Externí odkaz:
https://doaj.org/article/f909cbdab341455d9f702b6081a46e6f