Single-cell dynamics of pannexin-1-facilitated programmed ATP loss during apoptosis

Autor: Hiromi Imamura, Shuichiro Sakamoto, Tomoki Yoshida, Yusuke Matsui, Silvia Penuela, Dale W Laird, Shin Mizukami, Kazuya Kikuchi, Akira Kakizuka

Publikováno v: eLife, Vol 9 (2020)

ATP is essential for all living cells. However, how dead cells lose ATP has not been well investigated. In this study, we developed new FRET biosensors for dual imaging of intracellular ATP level and caspase-3 activity in single apoptotic cultured hu

Externí odkaz: https://doaj.org/article/81e40b1c05a649a98151563b8a7d363f

Author response: Single-cell dynamics of pannexin-1-facilitated programmed ATP loss during apoptosis

Autor: Hiromi Imamura, Shuichiro Sakamoto, Tomoki Yoshida, Yusuke Matsui, Silvia Penuela, Dale W Laird, Shin Mizukami, Kazuya Kikuchi, Akira Kakizuka

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::eac25419140669eaf11422f75492fe8f
https://doi.org/10.7554/elife.61960.sa2

Tributyltin induces epigenetic changes and decreases the expression of nuclear respiratory factor-1

Autor: Keishi Ishida, Saki Hanaoka, Shigeru Ohta, Seigo Sanoh, Shuichiro Sakamoto, Saki Tanaka, Yaichiro Kotake, Katsuhiro Okuda

Publikováno v: Metallomics : integrated biometal science. 10(2)

Tributyltin (TBT), a common organotin environmental pollutant, has been widely used as a component of marine antifouling paints. We previously reported that exposure to TBT inhibits the expression and DNA binding of nuclear respiratory factor-1 (NRF-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1b0b61232676d51ef74cb688a39b5b0
https://pubmed.ncbi.nlm.nih.gov/29345269

Endogenous neurotoxic dopamine derivative covalently binds to Parkinson's disease-associated ubiquitin C-terminal hydrolase L1 and alters its structure and function

Autor: Viorica Raluca Contu, Shigeru Ohta, Shuichiro Sakamoto, Masatsugu Miyara, Shigeyoshi Samizo, Takashi Toyama, Yaichiro Kotake, Katsuhiro Okuda, Seigo Sanoh, Yoshito Kumagai

Publikováno v: Journal of Neurochemistry. 130:826-838

Parkinson's disease (PD) is a common neurodegenerative disease, but its pathogenesis remains elusive. A mutation in ubiquitin C-terminal hydrolase L1 (UCH-L1) is responsible for a form of genetic PD which strongly resembles the idiopathic PD. We prev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c74b9312f5b8ee6be789201c0d3b1661
https://doi.org/10.1111/jnc.12762

Low-Concentration Tributyltin Decreases GluR2 Expression via Nuclear Respiratory Factor-1 Inhibition

Autor: Shigeru Ohta, Kaori Aoki, Yaichiro Kotake, Yasunari Kanda, Tomoki Kimura, Masatsugu Miyara, Seigo Sanoh, Keishi Ishida, Shuichiro Sakamoto, Tomoko Takishita

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 18, Iss 8, p 1754 (2017)
International Journal of Molecular Sciences; Volume 18; Issue 8; Pages: 1754

Tributyltin (TBT), which has been widely used as an antifouling agent in paints, is a common environmental pollutant. Although the toxicity of high-dose TBT has been extensively reported, the effects of low concentrations of TBT are relatively less w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c857218aabd6c12b436284783aec72d
https://doi.org/10.3390/ijms18081754