Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Shuichiro Ito"'
Publikováno v:
ACS Med Chem Lett
[Image: see text] A novel class of estrogen-related receptor α (ERRα) agonists has been discovered. A structure–activity relationship study of high-throughput screening hits 1 and 2 led to the discovery of benzimidazole 3d (DS20362725) and acetop
Publikováno v:
Drug Discovery Today. 19:1205-1211
The recent success reported in late-stage clinical trials for the treatment of psoriasis by antibodies directed against interleukin (IL)-17 or its receptor has validated and strongly supports the development of inhibitors of the IL-17 pathway as a ne
Autor:
Fujio Isono, Takao Ohyama, Saori Fujita-Sato, Takashi Isobe, Kaoru Morishita, Kenji Wakabayashi, Shuichiro Ito, Osamu Ando
Publikováno v:
Journal of Biological Chemistry. 286:31409-31417
The retinoic acid-related orphan nuclear receptor γt (RORγt)/RORγ2 is well known as a master regulator of interleukin 17 (IL-17)-producing helper T (Th17) cell development. To develop a therapeutic agent against Th17-mediated autoimmune diseases,
Publikováno v:
Journal of Natural Products. 71:595-601
Napyradiomycin SR ( 1), 16-dechloro-16-hydroxynapyradiomycin C2 ( 2), 18-hydroxynapyradiomycin A1 ( 3), 18-oxonapyradiomycin A1 ( 4), 16-oxonapyradiomycin A2 ( 5), 7-demethyl SF2415A3 ( 6), 7-demethyl A80915B ( 7), and ( R)-3-chloro-6-hydroxy-8-metho
Autor:
Florian P. Seebeck, Donald Hilvert, Shuichiro Ito, Erik W. Debler, Ian A. Wilson, Andreas Heine
Publikováno v:
Proceedings of the National Academy of Sciences. 102:4984-4989
Antibody 34E4 catalyzes the conversion of benzisoxazoles to salicylonitriles with high rates and multiple turnovers. The crystal structure of its complex with the benzimidazolium hapten at 2.5-Å resolution shows that a combination of hydrogen bondin
Autor:
Shinko Hayashi, Tadashi Hata, Shuichiro Ito, Fumihiko Okada, Osamu Ubukata, Kenji Wakabayashi
Publikováno v:
Journal of Biological Chemistry. 277:6631-6636
Bone remodeling involves the resorption of bone by osteoclasts and the synthesis of bone matrix by osteoblasts. Receptor activator of NF-kappa B ligand (RANKL, also known as ODF and OPGL), a member of the tumor necrosis factor (TNF) family, triggers
Autor:
Shin Yonehara, Jun Ohsumi, Reimi Kawaida, Hiroyuki Hanzawa, Shuichiro Ito, Tadashi Hata, Tohru Takahashi, Tomoko Takayama, Kimihisa Ichikawa, Kenji Miyadai, Hiroko Yoshida-Kato, Junko Yamaguchi, Hideyuki Haruyama, Nobufusa Serizawa
Publikováno v:
Biological and Pharmaceutical Bulletin. 25:1537-1545
Binding of Fas ligand to Fas induces apoptosis. The Fas-Fas ligand system plays important roles in many biological processes, including the elimination of autoreactive lymphoid cells. We have previously obtained the mouse anti-Fas antibody HFE7A (m-H
Autor:
Tsuneaki Ogata, Ryutaro Nakashima, Shuichiro Ito, Koji Matsumoto, Nobuaki Watanabe, Tomoko Yoneyama, Tatsuya Yano, Rieko Takano, Takeshi Honda, Narihiro Toda, Masahiro Inoue, Masakazu Hirouchi, Masao Yoshida
Publikováno v:
ACS medicinal chemistry letters. 6(3)
GPR40 is a G protein-coupled receptor that is predominantly expressed in pancreatic β-cells. GPR40 agonists stimulate insulin secretion in the presence of high glucose concentration. On the basis of this mechanism, GPR40 agonists are possible novel
Autor:
Shuichiro Ito
Publikováno v:
Japanese Journal of Political Science. 2:211-235
The central theme of Japanese subnational governmental study has been center–local relations. Researchers looked into the question of whether Japanese subnational governments have sufficient autonomy to pursue their own preferences. In other words,
Publikováno v:
Analytica Chimica Acta. 424:57-63
Alkaline phosphatase (ALP), a labeling enzyme frequently used for enzyme immunoassay, was determined at the attomole level using a mushroom tyrosinase (TN)-embedded carbon paste electrode. The detection scheme consists of two successive amplification