Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Shuichiro Hirahara"'
Autor:
Siddharth Narendran, Felipe Pereira, Praveen Yerramothu, Ivana Apicella, Shao-bin Wang, Kameshwari Ambati, Shuichiro Hirahara, Younghee Kim, Meenakshi Ambati, Vidya L. Ambati, Peirong Huang, Akhil Varshney, Yosuke Nagasaka, Shinichi Fukuda, Kirstie L. Baker, Kenneth M. Marion, Jan M. Deussing, Srinivas R. Sadda, Bradley D. Gelfand, Jayakrishna Ambati
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-9 (2021)
Abstract Nonfibrillar amyloid-β oligomers (AβOs) are a major component of drusen, the sub-retinal pigmented epithelium (RPE) extracellular deposits characteristic of age-related macular degeneration (AMD), a common cause of global blindness. We rep
Externí odkaz:
https://doaj.org/article/3b63bb9d0ace4f3fbe816152ffbe4d39
Autor:
Jayakrishna Ambati, Joseph Magagnoli, Hannah Leung, Shao-bin Wang, Chris A. Andrews, Dongxu Fu, Akshat Pandey, Srabani Sahu, Siddharth Narendran, Shuichiro Hirahara, Shinichi Fukuda, Jian Sun, Lekha Pandya, Meenakshi Ambati, Felipe Pereira, Akhil Varshney, Tammy Cummings, James W. Hardin, Babatunde Edun, Charles L. Bennett, Kameshwari Ambati, Benjamin J. Fowler, Nagaraj Kerur, Christian Röver, Norbert Leitinger, Brian C. Werner, Joshua D. Stein, S. Scott Sutton, Bradley D. Gelfand
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Inflammasome activation may contribute to type 2 diabetes, but whether targeting inflammasome is beneficial is unclear. Here the authors show that repurposing nucleoside reverse transcriptase inhibitors for inhibiting inflammasome activation is assoc
Externí odkaz:
https://doaj.org/article/3c663125a9b94db7a11c2309f51581c5
Publikováno v:
Clinical Ophthalmology, Vol 2010, Iss default, Pp 1115-1118 (2010)
Shuichiro Hirahara, Yoshio Hirano, Tsutomu Yasukawa, Yuichiro OguraDepartment of Ophthalmology and Visual Science, Nagoya City University Graduate School of Medical Sciences, Nagoya, JapanAbstract: We present a case of retinitis pigmentosa with vitre
Externí odkaz:
https://doaj.org/article/33cb8fec367d46b491ff9ef053c70a06
Autor:
Yoshio Hirano, Tsutomu Yasukawa, Yuichiro Ogura, Ryo Kurobe, Munenori Yoshida, Kazuhiko Sugitani, Shuichiro Hirahara
Publikováno v:
Canadian Journal of Ophthalmology. 55:500-508
To investigate a 3-dimensional analysis of choroidal vessels using binarization of ultrawide-field indocyanine green angiography (UWFICGA) images and swept-source optical coherence tomography (SS-OCT) images before and after treatment in eyes with Vo
Autor:
Vidya L. Ambati, Ivana Apicella, Srinivas R. Sadda, Peirong Huang, Akhil Varshney, Nagaraj Kerur, Shaobin Wang, Meenakshi Ambati, Felipe Pereira, Siddharth Narendran, Kameshwari Ambati, Kirstie Baker, Yosuke Nagasaka, Dionne Argyle, Bo Liu, Bradley D. Gelfand, Kenneth M. Marion, Tamer Sallam, Scott W. Canna, Kartik Gupta, Praveen Yerramothu, Jayakrishna Ambati, Shuichiro Hirahara, David R. Hinton
Publikováno v:
Science Immunology. 6
Detection of microbial products by multiprotein complexes known as inflammasomes is pivotal to host defense against pathogens. Nucleotide-binding domain leucine-rich repeat (NLR) CARD domain containing 4 (NLRC4) forms an inflammasome in response to b
Autor:
Shuichiro Hirahara, Tetsuro Oshika, Siddharth Narendran, J. Ignacio Aguirre, Shinichi Fukuda, Meenakshi Ambati, Benjamin J. Fowler, Praveen Yerramothu, Bradley D. Gelfand, David R. Hinton, Jayakrishna Ambati, Gerald G. Schumann, Ulrike Held, Yosuke Nagasaka, Felipe Pereira, Kirstie Baker, Nagaraj Kerur, Srinivas R. Sadda, Sanford H. Feldman, Shaobin Wang, Akhil Varshney, Peirong Huang, Ryan D. Makin, Kameshwari Ambati, Vera L. Bonilha, Mo Wang, Tetsuhiro Yasuma, Reo Yasuma, Vidya L. Ambati, Elmira Baghdasaryan, Xiwen Huang, Hiroko Terasaki, Daipayan Banerjee, Ivana Apicella, Kenneth M. Marion, Genrich V. Tolstonog, Yuichiro Ogura, Deepak Bhattarai, Kyung Bo Kim
Publikováno v:
Science advances, 7(40):eabj3658
Science Advances
Science advances, vol. 7, no. 40, pp. eabj3658
Science Advances
Science advances, vol. 7, no. 40, pp. eabj3658
Description
Endogenous Alu cDNA triggers inflammasome-mediated cell death in age-related macular degeneration.
Long interspersed nuclear element-1 (L1)–mediated reverse transcription (RT) of Alu RNA into cytoplasmic Alu complementary DNA
Endogenous Alu cDNA triggers inflammasome-mediated cell death in age-related macular degeneration.
Long interspersed nuclear element-1 (L1)–mediated reverse transcription (RT) of Alu RNA into cytoplasmic Alu complementary DNA
Autor:
Bradley D. Gelfand, Yosuke Nagasaka, Peirong Huang, Kenneth M. Marion, Shaobin Wang, Jayakrishna Ambati, Vidya L. Ambati, Shinichi Fukuda, Kirstie Baker, Srinivas R. Sadda, Siddharth Narendran, Akhil Varshney, Ivana Apicella, Meenakshi Ambati, Jan M. Deussing, Praveen Yerramothu, Felipe Pereira, Younghee Kim, Kameshwari Ambati, Shuichiro Hirahara
Publikováno v:
Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-9 (2021)
Signal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-9 (2021)
Nonfibrillar amyloid-β oligomers (AβOs) are a major component of drusen, the sub-retinal pigmented epithelium (RPE) extracellular deposits characteristic of age-related macular degeneration (AMD), a common cause of global blindness. We report that
Autor:
Shinichi, Fukuda, Akhil, Varshney, Benjamin J, Fowler, Shao-Bin, Wang, Siddharth, Narendran, Kameshwari, Ambati, Tetsuhiro, Yasuma, Joseph, Magagnoli, Hannah, Leung, Shuichiro, Hirahara, Yosuke, Nagasaka, Reo, Yasuma, Ivana, Apicella, Felipe, Pereira, Ryan D, Makin, Eamonn, Magner, Xinan, Liu, Jian, Sun, Mo, Wang, Kirstie, Baker, Kenneth M, Marion, Xiwen, Huang, Elmira, Baghdasaryan, Meenakshi, Ambati, Vidya L, Ambati, Akshat, Pandey, Lekha, Pandya, Tammy, Cummings, Daipayan, Banerjee, Peirong, Huang, Praveen, Yerramothu, Genrich V, Tolstonog, Ulrike, Held, Jennifer A, Erwin, Apua C M, Paquola, Joseph R, Herdy, Yuichiro, Ogura, Hiroko, Terasaki, Tetsuro, Oshika, Shaban, Darwish, Ramendra K, Singh, Saghar, Mozaffari, Deepak, Bhattarai, Kyung Bo, Kim, James W, Hardin, Charles L, Bennett, David R, Hinton, Timothy E, Hanson, Christian, Röver, Keykavous, Parang, Nagaraj, Kerur, Jinze, Liu, Brian C, Werner, S Scott, Sutton, Srinivas R, Sadda, Gerald G, Schumann, Bradley D, Gelfand, Fred H, Gage, Jayakrishna, Ambati
Publikováno v:
Proc Natl Acad Sci U S A
Alu retroelements propagate via retrotransposition by hijacking long interspersed nuclear element-1 (L1) reverse transcriptase (RT) and endonuclease activities. Reverse transcription of Alu RNA into complementary DNA (cDNA) is presumed to occur exclu
Autor:
Vidya L. Ambati, Mo Wang, Kyung Bo Kim, Joseph R. Herdy, Siddharth Narendran, Yuichiro Ogura, Bradley D. Gelfand, Eamonn Magner, Jayakrishna Ambati, Apuã C. M. Paquola, Christian Röver, Benjamin J. Fowler, Timothy Hanson, Meenakshi Ambati, Lekha Pandya, Ramendra K. Singh, Yosuke Nagasaka, Kirstie Baker, Jian Sun, James W. Hardin, Jinze Liu, Reo Yasuma, Charles L. Bennett, Genrich V. Tolstonog, Deepak Bhattarai, Praveen Yerramothu, Akshat Pandey, Daipayan Banerjee, Tetsuro Oshika, Gerald G. Schumann, Xinan Liu, Srinivas R. Sadda, Kameshwari Ambati, Tammy H. Cummings, Shaban Darwish, Akhil Varshney, Keykavous Parang, Saghar Mozaffari, Ryan D. Makin, Peirong Huang, Kenneth M. Marion, Elmira Baghdasaryan, Shaobin Wang, Hannah Leung, Brian C. Werner, Jennifer A. Erwin, Nagaraj Kerur, Xiwen Huang, Hiroko Terasaki, Felipe Pereira, S Scott Sutton, Shuichiro Hirahara, David R. Hinton, Ulrike Held, Joseph Magagnoli, Shinichi Fukuda, Ivana Apicella, Fred H. Gage, Tetsuhiro Yasuma
Publikováno v:
Proceedings of the National Academy of Sciences. 118
Significance Alu elements, comprising more than 10% of the human genome, propagate via retrotransposition. This genomic expansion requires enzymatic activity of L1 that reverse transcribes Alu RNA into Alu cDNA in the nucleus. We report Alu also unde
Autor:
Bradley D. Gelfand, Nagaraj Kerur, Yosuke Nagasaka, Ambati Balamurali K, Shinichi Fukuda, Jayakrishna Ambati, Charles B. Wright, Benjamin J. Fowler, Bo Chang, Tetsuhiro Yasuma, Siddharth Narendran, Izuho Hatada, Reo Yasuma, Philippe Georgel, Ana Bastos-Carvalho, Felipe Pereira, Romulo Albuquerque, Younghee Kim, Shuichiro Hirahara, Ivana Apicella, Hironori Uehara, Ryan D. Makin
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance DICER1 processes micro-RNAs into their bioactive forms and metabolizes RNAs from short interspersed nuclear element genetic repeats, principally Alu RNAs in humans. DICER1 deficiency is implicated in retinal pigmented epithelium (RPE) de