Zobrazeno 1 - 10
of 209
pro vyhledávání: '"Shuichi Hirai"'
Autor:
Yuki Katoh, Akiko Kubo, Nobuki Hayashi, Toshihiro Sugi, Kanoko Katoh, Seiichi Udagawa, Tadashi Ogawa, Takashi Iwata, Hiroshi Nishio, Masaki Sugawara, Shuichi Hirai, Kei Kawana
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract Despite widespread cervical cancer (CC) screening programs, low participation has led to high morbidity and mortality rates, especially in developing countries. Because early-stage CC often has no symptoms, a non-invasive and convenient diag
Externí odkaz:
https://doaj.org/article/0f4a5207188b4c709e4af8153c0855cf
Autor:
Toshikatsu Ikeda, Yuki Katoh, Hirotsugu Hino, Daichi Seta, Tadashi Ogawa, Takashi Iwata, Hiroshi Nishio, Masaki Sugawara, Shuichi Hirai
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-9 (2024)
Abstract Stearoyl-CoA desaturase 1 (SCD1) is an attractive target for cancer therapy. However, the clinical efficacy of SCD1 inhibitor monotherapy is limited. There is thus a need to elucidate the mechanisms of resistance to SCD1 inhibition and devel
Externí odkaz:
https://doaj.org/article/f3aa575b4baa416fbc0f3b6f8f9c264e
Autor:
Tomonori Harada, Isao Tsuboi, Hirotsugu Hino, Miyuki Yuda, Yoko Hirabayashi, Shuichi Hirai, Shin Aizawa
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening systemic hyper-inflammatory disorder. The mortality of HLH is higher in the elderly than in young adults. Senescence-accelerated mice (SAMP1/TA-1) exhibit characteristic accelera
Externí odkaz:
https://doaj.org/article/035b3c59f87d46d493245ef75060b768
Autor:
Eizo Marutani, Masanobu Morita, Shuichi Hirai, Shinichi Kai, Robert M. H. Grange, Yusuke Miyazaki, Fumiaki Nagashima, Lisa Traeger, Aurora Magliocca, Tomoaki Ida, Tetsuro Matsunaga, Daniel R. Flicker, Benjamin Corman, Naohiro Mori, Yumiko Yamazaki, Annabelle Batten, Rebecca Li, Tomohiro Tanaka, Takamitsu Ikeda, Akito Nakagawa, Dmitriy N. Atochin, Hideshi Ihara, Benjamin A. Olenchock, Xinggui Shen, Motohiro Nishida, Kenjiro Hanaoka, Christopher G. Kevil, Ming Xian, Donald B. Bloch, Takaaki Akaike, Allyson G. Hindle, Hozumi Motohashi, Fumito Ichinose
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
The brain is sensitive to oxygen deprivation. Here, the authors show in experimental animals that sensitivity to hypoxia is inversely related to the level of sulfide:quinone oxidoreductast (SQOR) and the capacity to catabolize sulfide in the brain.
Externí odkaz:
https://doaj.org/article/e9e4bccfec79480492fb63f03e33bd26
Autor:
Kumpei Takahashi, Kenta Nagahori, Ning Qu, Miyuki Kuramasu, Yoshie Hirayanagi, Shogo Hayashi, Yuki Ogawa, Naoyuki Hatayama, Hayato Terayama, Kaori Suyama, Shuichi Hirai, Kou Sakabe, Masahiro Itoh
Publikováno v:
BMC Complementary and Alternative Medicine, Vol 19, Iss 1, Pp 1-10 (2019)
Abstract Background Infertility and gonadal dysfunction are well known side-effects by cancer treatment in males. In particularly, chemotherapy and radiotherapy induced testicular damage, resulting in prolonged azoospermia. However, information regar
Externí odkaz:
https://doaj.org/article/aacdfa7129d4471684927a2c77eed111
Autor:
Akimasa Asai, Naoyuki Hatayama, Keisuke Kamiya, Mai Yamauchi, Hiroshi Kinashi, Makoto Yamaguchi, Takayuki Katsuno, Hironobu Nobata, Kazushi Watanabe, Akihiko Wakatsuki, Jan Aten, Shoichi Maruyama, Takuji Ishimoto, Shuichi Hirai, Munekazu Naito, Yasuhiko Ito
Publikováno v:
Physiological Reports, Vol 9, Iss 17, Pp n/a-n/a (2021)
Abstract Vascular endothelial cells are covered with glycocalyx comprising heparan sulfate, hyaluronan, chondroitin sulfate, and associated proteins. Glomerular endothelial glycocalyx is involved in protecting against induction of proteinuria and str
Externí odkaz:
https://doaj.org/article/110e79aa78b548a3aaae8ebed1bea416
Autor:
Miyuki Yuda, Shin Aizawa, Isao Tsuboi, Yoko Hirabayashi, Tomonori Harada, Hirotsugu Hino, Shuichi Hirai
Publikováno v:
Biological and Pharmaceutical Bulletin. 45:1602-1608
Lipopolysaccharide (LPS) treatment induced hemophagocytic lymphohistiocytosis in senescence-accelerated mice (SAMP1/TA-1), but not in senescence-resistant control mice (SAMR1). SAMP1/TA-1 treated with LPS exhibited functional impairment of the hemato
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::717db705cf91e2e6735898c1f2cd612f
https://doi.org/10.1248/bpb.b22-00108
https://doi.org/10.1248/bpb.b22-00108
Autor:
Shuichi Hirai, Naoyuki Hatayama, Munekazu Naito, Kenta Nagahori, Shinichi Kawata, Shogo Hayashi, Ning Qu, Hayato Terayama, Sunao Shoji, Masahiro Itoh
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
Abstract Many studies on various organs have concluded that venous congestion (VC) causes severe organ dysfunction with elevation of oxidative stress relative to that of arterial ischaemia (AI). However, a comparison of the pathological effects of AI
Externí odkaz:
https://doaj.org/article/f4ef5fff811042e0ac2e675e7b9f0122
Autor:
Shuichi Hirai
Publikováno v:
Journal of Nihon University Medical Association. 81:113-116
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9878924944f6eb745e6c98221bb6d376
https://doi.org/10.4264/numa.81.2_113
https://doi.org/10.4264/numa.81.2_113
Autor:
Kenta Nagahori, Miyuki Kuramasu, Shinichi Kawata, Tomiko Yakura, Zhonglian Li, Shuichi Hirai, Ning Qu, Masahiro Itoh
Publikováno v:
Histochemistry and Cell Biology. 157:309-319
Male haploid cells, spermatids and spermatozoa, that appear after the establishment of immune tolerance express novel cell surface and intracellular proteins that can be recognized as foreign antigens by the self-immune system. However, these germ ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fde6b265bb71997114cd6d2be769b60d
https://doi.org/10.1007/s00418-021-02061-1
https://doi.org/10.1007/s00418-021-02061-1