Zobrazeno 1 - 10
of 240
pro vyhledávání: '"Shuichi, Hirono"'
Autor:
Yuri Komaki, Yoshinori Ozono, Kenichi Nakamura, Hisayoshi Iwakiri, Satoru Hasuike, Mitsue Sueta, Tadashi Miike, Shojiro Yamamoto, Hirofumi Uto, Kazunori Kusumoto, Toshimasa Ochiai, Junya Kato, Naoto Komada, Kazuo Kuroki, Toshiharu Eto, Masafumi Shigehira, Shuichi Hirono, Kenji Nagata, Hiroshi Kawakami
Publikováno v:
BMC Gastroenterology, Vol 22, Iss 1, Pp 1-9 (2022)
Abstract Background It is estimated that approximately 50% of patients with hepatitis C virus (HCV) infection in Japan are currently over 75 years old. However, patients aged ≥ 75 years are typically underrepresented in clinical trials of direct-ac
Externí odkaz:
https://doaj.org/article/7474353ef2834ff3a2f22d0d85ec24a5
Autor:
Atsushi Kato, Izumi Nakagome, Mizuki Hata, Robert J. Nash, George W. J. Fleet, Yoshihiro Natori, Yuichi Yoshimura, Isao Adachi, Shuichi Hirono
Publikováno v:
Molecules, Vol 25, Iss 12, p 2843 (2020)
Deoxynojirimycin (DNJ) is the archetypal iminosugar, in which the configuration of the hydroxyl groups in the piperidine ring truly mimic those of d-glucopyranose; DNJ and derivatives have beneficial effects as therapeutic agents, such as anti-diabet
Externí odkaz:
https://doaj.org/article/40f631e564e84a238489d0be7c8c45d9
Autor:
Keishi Yamasaki, Saya Hyodo, Kazuaki Taguchi, Koji Nishi, Noriyuki Yamaotsu, Shuichi Hirono, Victor Tuan Giam Chuang, Hakaru Seo, Toru Maruyama, Masaki Otagiri
Publikováno v:
PLoS ONE, Vol 12, Iss 6, p e0180404 (2017)
A wide variety of drugs bind to human serum albumin (HSA) at its two principal sites, namely site I and site II. A number of reports indicate that drug binding to these two binding sites are not completely independent, and that interactions between l
Externí odkaz:
https://doaj.org/article/e2737e07d66c471eb742d24ac1b3b2d8
Autor:
Yosuke Kaneko, Shin-ichiro Ozawa, Yuiko Sato, Tami Kobayashi, Tatsuaki Matsumoto, Kana Miyamoto, Shu Kobayashi, Kengo Harato, Shuichi Hirono, Morio Matsumoto, Masaya Nakamura, Yasuo Niki, Takeshi Miyamoto
BackgroundRheumatoid arthritis (RA) is a disease characterized by chronic joint inflammation, pain and joint destruction, leading to alteration in activities of daily living, yet pathological mechanisms underlying the condition are not fully clarifie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d75a5a24c8bb4fa596eeddd43581aaa9
https://doi.org/10.21203/rs.3.rs-1557402/v2
https://doi.org/10.21203/rs.3.rs-1557402/v2
Publikováno v:
Journal of Computer-Aided Molecular Design. 35:601-611
Enhancer of zeste homolog 2 (EZH2) is a histone lysine methyltransferase that is overexpressed in many cancers. Numerous EZH2 inhibitors have been developed as anticancer agents, but recent studies have also focused on protein-protein interaction (PP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85ab9fbb714947f9cdeea26be1e7a002
https://doi.org/10.1007/s10822-021-00378-6
https://doi.org/10.1007/s10822-021-00378-6
Autor:
Shuichi Fukuyoshi, Masaharu Kometani, Yurie Watanabe, Masahiro Hiratsuka, Noriyuki Yamaotsu, Shuichi Hirono, Noriyoshi Manabe, Ohgi Takahashi, Akifumi Oda
Publikováno v:
PLoS ONE, Vol 11, Iss 4, p e0152946 (2016)
Many natural mutants of the drug metabolizing enzyme cytochrome P450 (CYP) 2D6 have been reported. Because the enzymatic activities of many mutants are different from that of the wild type, the genetic polymorphism of CYP2D6 plays an important role i
Externí odkaz:
https://doaj.org/article/71633b9c7ada4c3984b59c6217842648
Autor:
Izumi Nakagome, Atsushi Kato, Noriyuki Yamaotsu, Tomoki Yoshida, Shin-ichiro Ozawa, Isao Adachi, Shuichi Hirono
Publikováno v:
Molecules, Vol 23, Iss 10, p 2683 (2018)
Some point mutations in β-glucocerebrosidase cause either improper folding or instability of this protein, resulting in Gaucher disease. Pharmacological chaperones bind to the mutant enzyme and stabilize this enzyme; thus, pharmacological chaperone
Externí odkaz:
https://doaj.org/article/712cacbe72cb492a9bef6dac5306b771
Autor:
Tatsuya Kitao, Tomohiro Miike, Takeda Shigemitsu, Yuma Ito, Shin-ichiro Ozawa, Masaki Fukui, Shuichi Hirono, Ko Morishita, Hiroaki Shirahase
Publikováno v:
Chemical and Pharmaceutical Bulletin. 67:1211-1224
A novel series of 2,6,7-substituted 3-unsubstituted 1,2,3,4-tetrahydroisoquinoline derivatives were synthesized to find a peroxisome proliferator-activated receptor γ (PPARγ) partial agonist. Among the derivatives, (E)-7-[2-(cyclopent-3-eny)-5-meth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d98780634c756f0bbbaff5e7a31f4e4c
https://doi.org/10.1248/cpb.c19-00541
https://doi.org/10.1248/cpb.c19-00541
Autor:
Shuichi Hirono, Tomoki Yoshida
Publikováno v:
Chemical and Pharmaceutical Bulletin. 67:546-555
We report a three-dimensional quantitative structure-activity relationship (3D-QSAR) analysis of CDK2 inhibitors using fragment molecular orbital (FMO) calculations and partial least squares (PLS) regression. In our analysis, fragment binding energie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::648b984f2b17bc30b271f441f22aa940
https://doi.org/10.1248/cpb.c18-00990
https://doi.org/10.1248/cpb.c18-00990
Autor:
Shuichi Hirono, Noriyuki Yamaotsu, Izumi Nakagome, Kensuke Misawa, Shin-ichiro Ozawa, Tomoki Yoshida
Publikováno v:
YAKUGAKU ZASSHI. 139:827-835
Proteolysis mediated by the ubiquitin-proteome system plays an important role in cancer. Recently, a deubiquitinating enzyme, ubiquitin-specific protease 7 (USP7) has attracted attention as a key regulator of the p53-human double minute 2 (HDM2) path
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c696a9945f1b76f1d85910998ecd374a
https://doi.org/10.1248/yakushi.19-00006
https://doi.org/10.1248/yakushi.19-00006