Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Shuichan, Xu"'
Autor:
Rachid Safi, Suzanne E. Wardell, Paige Watkinson, Xiaodi Qin, Marissa Lee, Sunghee Park, Taylor Krebs, Emma L. Dolan, Adam Blattler, Toshiya Tsuji, Surendra Nayak, Marwa Khater, Celia Fontanillo, Madeline A. Newlin, Megan L. Kirkland, Yingtian Xie, Henry Long, Emma C. Fink, Sean W. Fanning, Scott Runyon, Myles Brown, Shuichan Xu, Kouros Owzar, John D. Norris, Donald P. McDonnell
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Most prostate cancers express the androgen receptor (AR), and tumor growth and progression are facilitated by exceptionally low levels of systemic or intratumorally produced androgens. Thus, absolute inhibition of the androgen signaling axis
Externí odkaz:
https://doaj.org/article/46ae3691cddb47bb9982590cd3da970d
Autor:
Heather K. Raymon, Sabita Sankar, Peter Worland, Stacie S. Canan, Mehran F. Moghaddam, Brian E. Cathers, Zeen Tong, Wen Qing Yang, Tao Shi, Tam Tran, Sophie Perrin-Ninkovic, Sophie X. Peng, Samantha Richardson, Rene Bissonette, Rama Krishna Narla, Matt Hickman, Kamran Ghoreishi, Julius Apuy, Jingjing Zhao, Jim Leisten, James C. Gamez, Godrej Khambatta, Garrick Packard, Weiming Xu, Shuichan Xu, Kimberly E. Fultz, Deborah S. Mortensen
Supplementary Figures S1-S3, Tables S1-S7. Suppl. Figure S1: Prolif. Curves, PC3 Cell Cycle & solid tumor apoptosis Suppl. Figure S2: PK/PD Model Performance and eIF4E In Vivo Biomarker Suppl. Figure S3: HCT-116, MBA MD231 & A549 Efficacy Studies Sup
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::106516d185208367e68bb96ffc0bed07
https://doi.org/10.1158/1535-7163.22500843.v1
https://doi.org/10.1158/1535-7163.22500843.v1
Autor:
John F. Boylan, Jennifer R. Riggs, Heather K. Raymon, Ning Jiang, Tao Shi, Yuhong Ning, David Mikolon, Tam Tran, Rama Krishna Narla, Leo A. Barnes, Sophie X. Peng, Gordafaried Deyanat-Yazdi, Shuichan Xu, Dan Zhu
Historically, phenotypic-based drug discovery has yielded a high percentage of novel drugs while uncovering new tumor biology. CC-671 was discovered using a phenotypic screen for compounds that preferentially induced apoptosis in triple-negative brea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bc39d765a5b86cd0bea57f9dd0bcd25
https://doi.org/10.1158/1535-7163.c.6537733
https://doi.org/10.1158/1535-7163.c.6537733
Autor:
John F. Boylan, Jennifer R. Riggs, Heather K. Raymon, Ning Jiang, Tao Shi, Yuhong Ning, David Mikolon, Tam Tran, Rama Krishna Narla, Leo A. Barnes, Sophie X. Peng, Gordafaried Deyanat-Yazdi, Shuichan Xu, Dan Zhu
SUPPLEMENTAL METHODS • Correlative analysis of CC-671 sensitivity data with genomic features in the 240 Oncopanel • Correlative analysis of CC-671 sensitivity data with genomic features or tumor subtypes in 49 breast cancer cell lines â
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::345d2d16f0cdc9dbe61ef20d892594b3
https://doi.org/10.1158/1535-7163.22504438.v1
https://doi.org/10.1158/1535-7163.22504438.v1
Autor:
Heather K. Raymon, Sabita Sankar, Peter Worland, Stacie S. Canan, Mehran F. Moghaddam, Brian E. Cathers, Zeen Tong, Wen Qing Yang, Tao Shi, Tam Tran, Sophie Perrin-Ninkovic, Sophie X. Peng, Samantha Richardson, Rene Bissonette, Rama Krishna Narla, Matt Hickman, Kamran Ghoreishi, Julius Apuy, Jingjing Zhao, Jim Leisten, James C. Gamez, Godrej Khambatta, Garrick Packard, Weiming Xu, Shuichan Xu, Kimberly E. Fultz, Deborah S. Mortensen
mTOR is a serine/threonine kinase that regulates cell growth, metabolism, proliferation, and survival. mTOR complex-1 (mTORC1) and mTOR complex-2 (mTORC2) are critical mediators of the PI3K–AKT pathway, which is frequently mutated in many cancers,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4ce3c68a5bf01dbc4b5578e36679e558
https://doi.org/10.1158/1535-7163.c.6536589.v1
https://doi.org/10.1158/1535-7163.c.6536589.v1
Autor:
Paul S. Mischel, Timothy F. Cloughesy, Rajesh Chopra, Kristen Hege, James R. Heath, Guido Kroemer, C. David James, Frank B. Furnari, Webster K. Cavenee, Heather K. Raymon, Shuichan Xu, Deborah S. Mortensen, Bruno Bonetti, Yuchao Gu, Alvaro Assuncao, Kelly Lin, David Akhavan, Ivan Babic, Kazuhiro Tanaka, Shaojun Zhu, David Shackelford, Genaro R. Villa, David Nathanson, Huijun Yang, Shiro Ikegami, Kenta Masui, Tomoo Matsutani, Deliang Guo, Ciro Zanca, Beatrice Gini
PDF file - 2561K, Treatment with CC214-1, leads to induction of autophagy in GBM39 cells and genetic inhibition of autophagy sensitizes U87EGFRvIII cells to apoptosis.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8647dddc84f5c6d5a2c519d64501d378
https://doi.org/10.1158/1078-0432.22449395.v1
https://doi.org/10.1158/1078-0432.22449395.v1
Autor:
Paul S. Mischel, Timothy F. Cloughesy, Rajesh Chopra, Kristen Hege, James R. Heath, Guido Kroemer, C. David James, Frank B. Furnari, Webster K. Cavenee, Heather K. Raymon, Shuichan Xu, Deborah S. Mortensen, Bruno Bonetti, Yuchao Gu, Alvaro Assuncao, Kelly Lin, David Akhavan, Ivan Babic, Kazuhiro Tanaka, Shaojun Zhu, David Shackelford, Genaro R. Villa, David Nathanson, Huijun Yang, Shiro Ikegami, Kenta Masui, Tomoo Matsutani, Deliang Guo, Ciro Zanca, Beatrice Gini
PDF file - 5321K, In vitro and in vivo pharmacological inhibition of autophagy sensitizes U87EGFRvIII cells and orthotopic xenografts to CC214-1/CC214-2 mediated apoptosis.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b6c8d8bf85d619d92452068ce6bc33f
https://doi.org/10.1158/1078-0432.22449392.v1
https://doi.org/10.1158/1078-0432.22449392.v1
Autor:
Paul S. Mischel, Timothy F. Cloughesy, Rajesh Chopra, Kristen Hege, James R. Heath, Guido Kroemer, C. David James, Frank B. Furnari, Webster K. Cavenee, Heather K. Raymon, Shuichan Xu, Deborah S. Mortensen, Bruno Bonetti, Yuchao Gu, Alvaro Assuncao, Kelly Lin, David Akhavan, Ivan Babic, Kazuhiro Tanaka, Shaojun Zhu, David Shackelford, Genaro R. Villa, David Nathanson, Huijun Yang, Shiro Ikegami, Kenta Masui, Tomoo Matsutani, Deliang Guo, Ciro Zanca, Beatrice Gini
PDF file - 2080K, Tunable expression of EGFRvIII in genetically modified models correlates with autophagy induction upon CC214-1 treatment.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d2b1de3c6f56240d0579ff3504b6433
https://doi.org/10.1158/1078-0432.22449398.v1
https://doi.org/10.1158/1078-0432.22449398.v1
Autor:
Paul S. Mischel, Timothy F. Cloughesy, Rajesh Chopra, Kristen Hege, James R. Heath, Guido Kroemer, C. David James, Frank B. Furnari, Webster K. Cavenee, Heather K. Raymon, Shuichan Xu, Deborah S. Mortensen, Bruno Bonetti, Yuchao Gu, Alvaro Assuncao, Kelly Lin, David Akhavan, Ivan Babic, Kazuhiro Tanaka, Shaojun Zhu, David Shackelford, Genaro R. Villa, David Nathanson, Huijun Yang, Shiro Ikegami, Kenta Masui, Tomoo Matsutani, Deliang Guo, Ciro Zanca, Beatrice Gini
PDF file - 91K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3483c43cdc5efa5c2dd4ef44b7922c81
https://doi.org/10.1158/1078-0432.22449386.v1
https://doi.org/10.1158/1078-0432.22449386.v1
Autor:
Paul S. Mischel, Timothy F. Cloughesy, Rajesh Chopra, Kristen Hege, James R. Heath, Guido Kroemer, C. David James, Frank B. Furnari, Webster K. Cavenee, Heather K. Raymon, Shuichan Xu, Deborah S. Mortensen, Bruno Bonetti, Yuchao Gu, Alvaro Assuncao, Kelly Lin, David Akhavan, Ivan Babic, Kazuhiro Tanaka, Shaojun Zhu, David Shackelford, Genaro R. Villa, David Nathanson, Huijun Yang, Shiro Ikegami, Kenta Masui, Tomoo Matsutani, Deliang Guo, Ciro Zanca, Beatrice Gini
PDF file - 5300K, CC214-1 synergizes at low doses with rapamycin. Quantification of the blots shown in Fig. 2B. PTEN detection on DEAL captured GBM39 cells upon CC214-1 treatment.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dcdf12758410788442ca9cf00c17376
https://doi.org/10.1158/1078-0432.22449410.v1
https://doi.org/10.1158/1078-0432.22449410.v1