Výsledky vyhledávání - "Shui-juan Zhang"

Akademický článek

EETs Attenuate Ox-LDL-Induced LTB4 Production and Activity by Inhibiting p38 MAPK Phosphorylation and 5-LO/BLT1 Receptor Expression in Rat Pulmonary Arterial Endothelial Cells.

Autor: Jun-xia Jiang, Shui-juan Zhang, Yao-kang Xiong, Yong-liang Jia, Yan-hong Sun, Xi-xi Lin, Hui-juan Shen, Qiang-min Xie, Xiao-feng Yan

Publikováno v: PLoS ONE, Vol 10, Iss 6, p e0128278 (2015)

Cytochrome P-450 epoxygenase (EPOX)-derived epoxyeicosatrienoic acids (EETs), 5-lipoxygenase (5-LO), and leukotriene B4 (LTB4), the product of 5-LO, all play a pivotal role in the vascular inflammatory process. We have previously shown that EETs can

Externí odkaz: https://doaj.org/article/9169d39c64e84316b96deee1e0e9bf2c

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Inhibition of Rac1 activity alleviates PM2.5-induced pulmonary inflammation via the AKT signaling pathway

Autor: Weixi Zhang, Shui-juan Zhang, Ruijie Chen, Xin-wei Dong, Zhe Wang, Xixi Lin, Wei Zhao, Jian Shen, Xiaolei Zeng, Yong-liang Jia

Publikováno v: Toxicology Letters. 310:61-69

PM2.5 is the main particulate air pollutant that is capable of inducing airway injury. Previous studies have indicated that Rac1 is involved in cigarette smoke-induced lung inflammation and lipopolysaccharide-mediated pulmonary injury. However, the c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30202febcd33046b43d53a464b66b06a
https://doi.org/10.1016/j.toxlet.2019.04.017

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Ambroxol inhalation ameliorates LPS-induced airway inflammation and mucus secretion through the extracellular signal-regulated kinase 1/2 signaling pathway

Autor: Juan-xia Jiang, Hong Lu, Shui-juan Zhang, Yong-liang Jia, Qiang-min Xie, Jian Shen, Xi-xi Lin, Hui-juan Shen, Qian-qian Ren

Publikováno v: European Journal of Pharmacology. 775:138-148

Ambroxol, a metabolite of bromhexine, is shown to exert several pharmacological activities, including secretolytic, anti-inflammatory and antioxidant actions. Oral and intravenous administration of ambroxol is useful for the airway inflammatory disea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::787d80fadd92fc5eb3e70df438a02b83
https://doi.org/10.1016/j.ejphar.2016.02.030

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Effects of the Inhalation of the M3Receptor Antagonist Bencycloquidium Bromide in A Mouse Cigarette Smoke-Induced Airway Inflammation Model

Autor: Yao-kang Xiong, Qian-qian Ren, Qiang-min Xie, Shui-juan Zhang, Jun-xia Jiang

Publikováno v: Drug Development Research. 76:123-131

Bencycloquidium bromide (BCQB), a novel M3 receptor antagonist, alleviates airway hyperresponsiveness, inflammation, and airway remodeling in a murine model of asthma. The aim of this study was to investigate the anti-inflammatory activity of inhaled

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a428775ca1ef7282e391820ac4929825
https://doi.org/10.1002/ddr.21248

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Cigarette smoke extract-induced BEAS-2B cell apoptosis and anti-oxidative Nrf-2 up-regulation are mediated by ROS-stimulated p38 activation

Autor: Yan-hong Sun, Yan Guan, Xin-Fu Yang, Shui-Juan Zhang, Qiang-min Xie, Ya-Nan Liu, Xi-xi Lin, Jun-xia Jiang

Publikováno v: Toxicology Mechanisms and Methods. 24:575-583

Cigarette smoke contains reactive oxygen (ROS) that can cause oxidative stress. It increases the number of apoptotic and necrotic lung cells and further induces the development of chronic airway disease. In this study, we investigated the effects of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59b0e43fc0b0da271fcaaad87eb51a7c
https://doi.org/10.3109/15376516.2014.956909

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Cigarette smoke-induced alveolar epithelial–mesenchymal transition is mediated by Rac1 activation

Autor: Qiang-min Xie, Lin-hui Zhang, Jun-xia Jiang, Jian Shen, Xiao-Feng Yan, Fenfen Li, Ximei Wu, Yan-hong Sun, Xi-xi Lin, Shui-juan Zhang, Xin-wei Dong, Hui-juan Shen, Yong-liang Jia, Yan Guan

Publikováno v: Biochimica et Biophysica Acta (BBA) - General Subjects. 1840:1838-1849

Background Epithelial–mesenchymal transition (EMT) is the major pathophysiological process in lung fibrosis observed in chronic obstructive pulmonary disease (COPD) and lung cancer. Smoking is a risk factor for developing EMT, yet the mechanism rem

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf44354d33540ba39faf448420787c0f
https://doi.org/10.1016/j.bbagen.2014.01.033

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Akademický článek

Intracerebroventricular injection of leukotriene B4 attenuates antigen-induced asthmatic response via BLT1 receptor stimulating HPA-axis in sensitized rats.

Autor: Shui-Juan Zhang^1,2, Yang-Mei Deng¹, Yi-Liang Zhu¹, Xin-Wei Dong¹, Jun-Xia Jiang¹, Qiang-Min Xie¹ xieqm@zju.edu.cn

Publikováno v: Respiratory Research. 2010, Vol. 11, p39-47. 9p.

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Oral administration of allergen extracts from Dermatophagoides farinae desensitizes specific allergen-induced inflammation and airway hyperresponsiveness in rats

Autor: Jian-ping Zhu, Xin-wei Dong, Hui-min Wu, Shui-Juan Zhang, Qiang-min Xie, Ximei Wu, Yang-mei Deng

Publikováno v: International Immunopharmacology. 8:1639-1645

Clinically sublingual immunotherapy (SLIT) by using allergen extracts effectively alleviates the symptoms of allergic rhinitis and asthma. Supposed that oral administration of high-dose of allergen extracts imitates SLIT and may prevent IgE-related r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34f585588eca1e9adf4aead513b8200e
https://doi.org/10.1016/j.intimp.2008.07.015

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