Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Shuhei Osaka"'
Autor:
Yoko Nakajima, Shuhei Osaka, Tadahaya Mizuno, Katsuyuki Yokoi, Satoshi Nakano, Saeko Hirai, Yuka Hiraoka, Yoshiki Miura, Mitsuyoshi Suzuki, Hiroyuki Kusuhara, Hisamitsu Hayashi
Publikováno v:
Molecular Genetics and Metabolism Reports, Vol 29, Iss , Pp 100799- (2021)
Urea cycle disorders (UCDs), inborn errors of hepatocyte metabolism, cause hyperammonemia and lead to neurocognitive deficits, coma, and even death. Sodium 4-phenylbutyrate (NaPB), a standard adjunctive therapy for UCDs, generates an alternative path
Externí odkaz:
https://doaj.org/article/bd2ef431f75b4e2fb94027b6644be228
Autor:
Kihiro Wakasa, Ryutaro Tamura, Shuhei Osaka, Hajime Takei, Akihiro Asai, Hiroshi Nittono, Hiroyuki Kusuhara, Hisamitsu Hayashi
Publikováno v:
Hepatology Communications; Apr2024, Vol. 8 Issue 4, p1-11, 11p
Autor:
Hiroyuki Kusuhara, Mitsuyoshi Suzuki, Yoshiki Miura, Shuhei Osaka, Yusuke Sabu, Hisamitsu Hayashi, Ayumu Mizutani, Satoshi Nakano, Kei Minowa, Yuka Hiraoka, Tadahaya Mizuno, Saeko Hirai, Toshiaki Shimizu
Publikováno v:
Molecular Genetics and Metabolism. 132:220-226
Urea cycle disorders (UCDs), inborn errors of hepatocyte metabolism, result in the systemic accumulation of ammonia to toxic levels. Sodium 4-phenylbutyrate (NaPB), a standard therapy for UCDs for over 20 years, generates an alternative pathway of ni
Autor:
Eitaro Aihara, Ayumu Mizutani, Nakayuki Naritaka, Hiroyuki Kusuhara, Yusuke Sabu, Aiko Fukami, Kenneth D. R. Setchell, Christopher N. Mayhew, Takanori Takebe, Akihiro Asai, Shuhei Osaka, Hisamitsu Hayashi, Masahide Sakabe, Kokoro Sakabe, Takahisa Nakamura, Eriko Kishimoto, Yueh Chiang Hu, Wujuan Zhang, Stacey S. Huppert
Publikováno v:
Stem Cell Reports
Summary The bile salt export pump (BSEP) is responsible for the export of bile acid from hepatocytes. Impaired transcellular transport of bile acids in hepatocytes with mutations in BSEP causes cholestasis. Compensatory mechanisms to regulate the int
Autor:
Kazuhiko Bessho, Hiroyuki Kusuhara, Atsuko Nakazawa, Hironori Kusano, Ayano Inui, Saeko Hirai, Satoshi Nakano, Hisamitsu Hayashi, Kei Minowa, Satoshi Watanabe, Masayoshi Kage, Yusuke Sabu, Yoh Zen, Yoshihiro Azuma, Toshiaki Shimizu, Shuhei Osaka, Hiroki Kondou, Ken Tanikawa, Hidefumi Nakamura, Takeshi Kimura, Mitsuyoshi Suzuki
Publikováno v:
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
Progressive familial intrahepatic cholestasis (PFIC), a rare inherited disorder, progresses to liver failure in childhood. We have shown that sodium 4-phenylbutyrate (NaPB), a drug approved for urea cycle disorders (UCDs), has beneficial effects in P
Autor:
Atsuko Nakazawa, Hironori Kusano, Yoshihiro Azuma, Shuhei Osaka, Hidefumi Nakamura, Hiroyuki Kusuhara, Toshiaki Shimizu, Ken Tanikawa, Hisamitsu Hayashi, Kei Minowa, Takeshi Kimura, Yusuke Sabu, Kazuhiko Bessho, Mitsuyoshi Suzuki, Hiroki Kondou, Satoshi Nakano, Satoshi Watanabe, Yoh Zen, Masayoshi Kage, Saeko Hirai, Ayano Inui
Publikováno v:
SSRN Electronic Journal.
Progressive familial intrahepatic cholestasis (PFIC), a rare inherited recessive liver disease, progresses to liver failure in childhood. There is no effective medical therapy for PFIC. We and other groups have shown that sodium 4-phenylbutyrate (NaP