Zobrazeno 1 - 10
of 238
pro vyhledávání: '"Shuhei Nakamura"'
Autor:
Takayuki Sakai, Yu Sasaki, Yasuhiko Abe, Masakuni Shoji, Shoichi Nishise, Hidenori Sato, Makoto Yagi, Naoko Mizumoto, Yusuke Onozato, Kon Takashi, Yuki Miyano, Ryoko Murakami, Matsuki Umehara, Shuhei Nakamura, Minami Ito, Takahiro Watabe, Hiroko Tsuchiya, Hiroki Goto, Takahiro Miura, Ryo Sato, Yoshiyuki Ueno
Publikováno v:
Gastro Hep Advances, Vol 3, Iss 5, Pp 573-582 (2024)
Background and Aims: The increasing prevalence of obesity has significantly contributed to the global burden of colorectal cancer and the precancerous colorectal adenoma (CRA). Gut microbiota vary at each stage of colorectal carcinogenesis and partic
Externí odkaz:
https://doaj.org/article/aca7295c322e4768a89b14e63411a285
Publikováno v:
IET Information Security, Vol 17, Iss 2, Pp 210-226 (2023)
Abstract Multivariate public‐key cryptography (MPKC) is considered a leading candidate for post‐quantum cryptography (PQC). It is based on the hardness of the multivariate quadratic polynomial (MQ) problem, which is a problem of finding a solutio
Externí odkaz:
https://doaj.org/article/e2a22f47cb884da69729ba40fd8d45b3
Autor:
Takashi Kon, Yu Sasaki, Yasuhiko Abe, Yusuke Onozato, Makoto Yagi, Naoko Mizumoto, Takayuki Sakai, Matsuki Umehara, Minami Ito, Shuhei Nakamura, Hiroki Goto, Yoshiyuki Ueno
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract Obesity is a major risk factor for colorectal cancer (CRC). Sustained hyperglycemia destabilizes tumor suppressor ten-eleven translocation (TET) 2, which is a substrate of AMPK, thereby dysregulating 5-hydroxymethylcytosine (5-hmC). However,
Externí odkaz:
https://doaj.org/article/d18d5aeb754c4587a4c9796105d258e7
Publikováno v:
Autophagy Reports, Vol 1, Iss 1, Pp 542-545 (2022)
Externí odkaz:
https://doaj.org/article/4ba1d6d7bb8c4e8bbb048a88f3d21c28
Autor:
Yasuhiko Abe, Yu Sasaki, Makoto Yagi, Naoko Mizumoto, Yusuke Onozato, Takashi Kon, Masakuni Shoji, Kazuhiro Sakuta, Takayuki Sakai, Matsuki Umehara, Minami Ito, Shuhei Nakamura, Hidemoto Tsuchida, Yoshiyuki Ueno
Publikováno v:
DEN Open, Vol 3, Iss 1, Pp n/a-n/a (2023)
Abstract Objectives To assess the usefulness of linked color imaging (LCI), a recently developed image‐enhanced endoscopy technique, in the endoscopic diagnosis of eosinophilic esophagitis (EoE). Methods Thirty white light images (WLIs) and 30 WLI+
Externí odkaz:
https://doaj.org/article/a24b653fb2c849d7bd00163fa7328a6f
Autor:
Jun Nakamura, Takeshi Yamamoto, Yoshitsugu Takabatake, Tomoko Namba-Hamano, Satoshi Minami, Atsushi Takahashi, Jun Matsuda, Shinsuke Sakai, Hiroaki Yonishi, Shihomi Maeda, Sho Matsui, Isao Matsui, Takayuki Hamano, Masatomo Takahashi, Maiko Goto, Yoshihiro Izumi, Takeshi Bamba, Miwa Sasai, Masahiro Yamamoto, Taiji Matsusaka, Fumio Niimura, Motoko Yanagita, Shuhei Nakamura, Tamotsu Yoshimori, Andrea Ballabio, Yoshitaka Isaka
Publikováno v:
JCI Insight, Vol 8, Iss 4 (2023)
Obesity is a major risk factor for end-stage kidney disease. We previously found that lysosomal dysfunction and impaired autophagic flux contribute to lipotoxicity in obesity-related kidney disease, in both humans and experimental animal models. Howe
Externí odkaz:
https://doaj.org/article/156d37b505f54176b5d14d33821082db
Publikováno v:
STAR Protocols, Vol 3, Iss 3, Pp 101539- (2022)
Summary: Senescent cells accumulation is associated with aging and age-related diseases, and recent findings suggest that autophagy, the activity of the intracellular degradation system, decreases during senescence. In this protocol, we detail steps
Externí odkaz:
https://doaj.org/article/898d9cf009e3410dac5c44839b9ad729
Autor:
Shigeo Muro, Masaru Suzuki, Shuhei Nakamura, Jocelyn Ruoyi Wang, Elizabeth M. Garry, Wataru Sakamoto, Sabrina de Souza
Publikováno v:
Respiratory Research, Vol 22, Iss 1, Pp 1-14 (2021)
Abstract Background Escalation to triple therapy (long-acting muscarinic antagonist/β2-agonist, inhaled corticosteroid [ICS]) in chronic obstructive pulmonary disorder (COPD) is recommended for patients on LAMA/LABA combinations with frequent exacer
Externí odkaz:
https://doaj.org/article/4446fb88833a4fc4aa6faf07322102e1
Autor:
Yukako Oe, Keita Kakuda, Shin-Ichiro Yoshimura, Naohiro Hara, Junya Hasegawa, Seigo Terawaki, Yasuyoshi Kimura, Kensuke Ikenaka, Shiro Suetsugu, Hideki Mochizuki, Tamotsu Yoshimori, Shuhei Nakamura
Publikováno v:
PLoS Genetics, Vol 18, Iss 6, p e1010264 (2022)
Autophagy is an indispensable process that degrades cytoplasmic materials to maintain cellular homeostasis. During autophagy, double-membrane autophagosomes surround cytoplasmic materials and either fuse with endosomes (called amphisomes) and then ly
Externí odkaz:
https://doaj.org/article/50ae2e2999ad4446803a96263e7e291f
Publikováno v:
STAR Protocols, Vol 3, Iss 1, Pp 101018- (2022)
Summary: Following lysosomal damage, activation and nuclear translocation of transcription factor EB (TFEB) is the key event to maintain lysosomal homeostasis. Here, we describe steps to induce lysosomal damage in HeLa cells. This can be followed by
Externí odkaz:
https://doaj.org/article/1c68051c44d64ea899bc415320be5c21