Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Shuhei Kotoshiba"'
Autor:
Keiko Nakayama, Shuhei Kotoshiba, Anisa Rahim, Elisabeth Pfeiffenberger, Keiichi I. Nakayama, Philipp Kaldis, Lakshmi Gopinathan, Leah A. Vardy
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1843(2):436-445
Cyclin-dependent kinase 2 (Cdk2) is dispensable for mitotic cell cycle progression and Cdk2 knockout mice are viable due to the compensatory functions of other Cdks. In order to assess the role of Cdk2 under limiting conditions, we used Skp2 knockout
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2eb1939b09e295df092fd365541b1a7
Publikováno v:
Transgenic Research. 18:491-498
Early studies on cell cycle regulation were based on experiments in model systems (Yeast, Xenopus, Starfish, Drosophila) and have shaped the way we understand many events that control the cell cycle. Although these model systems are of great value, t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::572a6b68f4ce36c1a65048c871af5e3c
https://doi.org/10.1007/s11248-009-9276-x
https://doi.org/10.1007/s11248-009-9276-x
Autor:
Junichi Goto, Nariyasu Mano, Keiichi Iwakami, Toshifumi Niwa, Yoshinori Kato, Norihiro Kobayashi, Shuhei Kotoshiba
Publikováno v:
Analytical Chemistry. 78:2244-2253
To overcome the sensitivity limit in immunoassays for small molecules (haptens), we established a noncompetitive immunoenzymometric assay (IEMA) format that can detect attomole-range hapten molecules. We selected 11-deoxycortisol (11-DC; Mr 346.5), a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4de886dd109c02123c63a56e051b4c25
https://doi.org/10.1021/ac051858f
https://doi.org/10.1021/ac051858f
Autor:
Shuhei, Kotoshiba, Keiichi, Nakayama
Publikováno v:
Nihon rinsho. Japanese journal of clinical medicine. 63(11)
The cell cycle of eukaryotic cells is regulated by a series of protein complexes composed of cyclins and cyclin-dependent kinases (CDKs), the activity of which is suppressed by a group of CDK inhibitors (CKIs). Among the CKIs, p27 plays a pivotal rol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3a287700b098d86477bf383d616e9991
https://pubmed.ncbi.nlm.nih.gov/16277271
https://pubmed.ncbi.nlm.nih.gov/16277271
Autor:
Masahiro Shirakawa, Takumi Kamura, Shuhei Kotoshiba, Ichiro Onoyama, Kenichiro Fujiwara, Taichi Hara, Noboru Mizushima, Hidehisa Takahashi, Keiichi I. Nakayama
KPC2 (Kip1 ubiquitylation-promoting complex 2) together with KPC1 forms the ubiquitin ligase KPC, which regulates degradation of the cyclin-dependent kinase inhibitor p27 at the G(1) phase of the cell cycle. KPC2 contains a ubiquitin-like (UBL) domai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d83357129b67adbecb021dfa93795448
https://europepmc.org/articles/PMC1265808/
https://europepmc.org/articles/PMC1265808/
Publikováno v:
The Journal of biological chemistry. 280(18)
The cyclin-dependent kinase (CDK) inhibitor p27 is degraded at the G(0)-G(1) transition of the cell cycle by the ubiquitin-proteasome pathway in a Skp2-independent manner. We recently identified a novel ubiquitin ligase, KPC (Kip1 ubiquitylation-prom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddaf38bd6248e86d2c7ed813d8af9af8
https://pubmed.ncbi.nlm.nih.gov/15746103
https://pubmed.ncbi.nlm.nih.gov/15746103
Autor:
Joan W. Conaway, Daisuke Kohda, Takumi Kamura, Keiichi I. Nakayama, Ronald C. Conaway, Masaki Matsumoto, Shuhei Kotoshiba, Katsumi Maenaka
Publikováno v:
Genesdevelopment. 18(24)
The ECS (Elongin B/C-Cul2/Cul5-SOCS-box protein) complex is a member of a family of ubiquitin ligases that share a Cullin-Rbx module. SOCS-box proteins recruit substrates to the ECS complex and are linked to Cullin-Rbx via Elongin B/C. VHL has been i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6eaba92cc407187fc9463ea4948da5e5
https://pubmed.ncbi.nlm.nih.gov/15601820
https://pubmed.ncbi.nlm.nih.gov/15601820
Autor:
Takumi Kamura, Keiko Nakayama, Masayoshi Yada, Hiroyuki Imaki, Shuhei Kotoshiba, Taichi Hara, Keiichi I. Nakayama, Shigetsugu Hatakeyama, Noriko Ishida
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 100(18)
The abundance of the cyclin-dependent kinase (CDK) inhibitor p57 Kip2 , an important regulator of cell cycle progression, is thought to be controlled by the ubiquitin-proteasome pathway. The Skp1/Cul1/F-box (SCF)-type E3 ubiquitin ligase complex SCF
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16240368553404803ce9e0d8417b35f2
https://pubmed.ncbi.nlm.nih.gov/12925736
https://pubmed.ncbi.nlm.nih.gov/12925736