Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Shuhei Kanagaki"'
Autor:
Shuhei Kanagaki, Yusuke Tsutsui, Naoki Kobayashi, Takashi Komine, Minoru Ito, Yunike Akasaka, Michiaki Nagasawa, Tomohiro Ide, Naoki Omae, Kazuhisa Nakao, Makoto Rembutsu, Maki Iwago, Aki Yonezawa, Yusei Hosokawa, Tetsuya Hosooka, Wataru Ogawa, Koji Murakami
Publikováno v:
iScience, Vol 26, Iss 4, Pp 106293- (2023)
Summary: 5′-Adenosine monophosphate-activated protein kinase (AMPK) is a potential therapeutic target for various medical conditions. We here identify a small-molecule compound (RX-375) that activates AMPK and inhibits fatty acid synthesis in cultu
Externí odkaz:
https://doaj.org/article/a92b50733fa44d83b46f3299ab983040
Autor:
Takahiro Suezawa, Shuhei Kanagaki, Yohei Korogi, Kazuhisa Nakao, Toyohiro Hirai, Koji Murakami, Masatoshi Hagiwara, Shimpei Gotoh
Publikováno v:
Respiratory Research, Vol 22, Iss 1, Pp 1-13 (2021)
Abstract Background Somatic cells differentiated from patient-specific human induced pluripotent stem cells (iPSCs) could be a useful tool in human cell-based disease research. Hermansky–Pudlak syndrome (HPS) is an autosomal recessive genetic disor
Externí odkaz:
https://doaj.org/article/4ebaca0035124502b6d85d268d034e87
Autor:
Kazuhisa Nakao, Yuki Yamamoto, Koji Murakami, Keita Moriguchi, Masatoshi Hagiwara, Shuhei Kanagaki, Takahiro Suezawa, Shimpei Gotoh, Masayasu Toyomoto
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology
Alveolar epithelial type II (AT2) cells secrete pulmonary surfactant via lamellar bodies (LBs). Abnormalities in LBs are associated with pulmonary disorders, including fibrosis. However, high-content screening (HCS) for LB abnormalities is limited by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afb6f307f7bf96ad93a9876e5999e933
https://doi.org/10.1165/rcmb.2020-0119oc
https://doi.org/10.1165/rcmb.2020-0119oc
Autor:
Shimpei Gotoh, Satoshi Ikeo, Yutaka Suzuki, Masahide Seki, Takahiro Suezawa, Shuhei Kanagaki, Yuki Yamamoto, Masatoshi Hagiwara, Toyohiro Hirai
Publikováno v:
Stem Cells (Dayton, Ohio)
Alveologenesis is a developmental step involving the expansion of the lung surface area which is essential for gas exchange. The gas exchange process is mediated by alveolar type I (AT1) cells, which are known to be differentiated from alveolar type
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34cd30bae123ae9b6414d150df4b5904
https://doi.org/10.1002/stem.3302
https://doi.org/10.1002/stem.3302
Autor:
Kazuhisa Nakao, Shuhei Kanagaki, Yohei Korogi, Shimpei Gotoh, Toyohiro Hirai, Koji Murakami, Takahiro Suezawa, Masatoshi Hagiwara
Publikováno v:
Respiratory Research
Respiratory Research, Vol 22, Iss 1, Pp 1-13 (2021)
Respiratory Research, Vol 22, Iss 1, Pp 1-13 (2021)
[Background] Somatic cells differentiated from patient-specific human induced pluripotent stem cells (iPSCs) could be a useful tool in human cell-based disease research. Hermansky–Pudlak syndrome (HPS) is an autosomal recessive genetic disorder cha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2519728eca2467cc45faea3ef426a14
https://pubmed.ncbi.nlm.nih.gov/34736469
https://pubmed.ncbi.nlm.nih.gov/34736469
Autor:
Takahiro Suezawa, Keita Moriguchi, Shuhei Kanagaki, Masatoshi Hagiwara, Koji Tamai, Toyohiro Hirai, Atsushi Masui, Koji Murakami, Masayasu Toyomoto, Shimpei Gotoh, Ryuta Mikawa, Kazuhisa Nakao
Publikováno v:
Stem Cell Reports
Summary Although alveolar epithelial cells play a critical role in the pathogenesis of pulmonary fibrosis, few practical in vitro models exist to study them. Here, we established a novel in vitro pulmonary fibrosis model using alveolar organoids cons
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11621ef89735acac1e312b2d83aaecd6
https://pubmed.ncbi.nlm.nih.gov/34798066
https://pubmed.ncbi.nlm.nih.gov/34798066
Autor:
Yuki Yamamoto, Yu Suke Torisawa, Toyofumi F. Chen-Yoshikawa, Sachiko Tsukita, Shuhei Kanagaki, Yohei Korogi, Shimpei Gotoh, Satoshi Ikeo, Yifei Xu, Yuichi Adachi, Masatoshi Hagiwara, Toyohiro Hirai, Kazuhiko Takeuchi, Naoyuki Sone, Toshinori Namba, Koji Tamai, Hiroshi Date, Satoshi Konishi, Koichi Igura
Publikováno v:
Science translational medicine. 13(601)
Mucociliary clearance is an essential lung function that facilitates the removal of inhaled pathogens and foreign matter unidirectionally from the airway tract and is innately achieved by coordinated ciliary beating of multiciliated cells. Should cil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::975cf0f2d62aab4ba2805bf03fb815f1
https://pubmed.ncbi.nlm.nih.gov/34233948
https://pubmed.ncbi.nlm.nih.gov/34233948
Hydroxypropyl Cyclodextrin Improves Amiodarone-induced Aberrant Lipid Homeostasis of Alveolar Cells.
Autor:
Shuhei Kanagaki, Takahiro Suezawa, Keita Moriguchi, Kazuhisa Nakao, Masayasu Toyomoto, Yuki Yamamoto, Koji Murakami, Masatoshi Hagiwara, Gotoh, Shimpei
Publikováno v:
American Journal of Respiratory Cell & Molecular Biology; Apr2021, Vol. 64 Issue 4, p504-514, 11p
Xanthohumol Impairs Autophagosome Maturation through Direct Inhibition of Valosin-Containing Protein
Autor:
Yasumitsu Kondoh, Hiroyuki Osada, Toshihiko Nogawa, Etsu Tashiro, Masaya Imoto, Shuhei Kanagaki, Yukiko Sasazawa, Makoto Muroi
Publikováno v:
ACS Chemical Biology. 7:892-900
Autophagy is a bulk, nonspecific protein degradation pathway that is involved in the pathogenesis of cancer and neurodegenerative disease. Here, we observed that xanthohumol (XN), a prenylated chalcone present in hops (Humulus lupulus L.) and beer, m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d075ed2f570d57b4127029230c736611
https://doi.org/10.1021/cb200492h
https://doi.org/10.1021/cb200492h
Autor:
Shuhei Kanagaki, Masaya Imoto, Masakatsu Shibasaki, Tomoyuki Kimura, Yusuke Matsui, Takumi Watanabe
Publikováno v:
Organic letters. 14(17)
Synthesis of the indenotryptoline bisindole alkaloid, BE-54017, was accomplished using osmium-promoted cis-dihydroxylation of maleimide as a key step. After optical resolution, the absolute configuration of this molecule was determined by comparing i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::278e6062127efad655c8a63c946e7bb2
https://pubmed.ncbi.nlm.nih.gov/22917065
https://pubmed.ncbi.nlm.nih.gov/22917065