Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Shuhe Tsai"'
Autor:
Emily Yun-Chia Chang, Shuhe Tsai, Maria J. Aristizabal, James P. Wells, Yan Coulombe, Franciele F. Busatto, Yujia A. Chan, Arun Kumar, Yi Dan Zhu, Alan Ying-Hsu Wang, Louis-Alexandre Fournier, Philip Hieter, Michael S. Kobor, Jean-Yves Masson, Peter C. Stirling
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Accumulations of R-loops can lead to genome instability. Here the authors reveal a role for the MRN complex in suppressing R-loops and associated DNA damage at transcription–replication conflicts.
Externí odkaz:
https://doaj.org/article/a6da048a2a604ec29f09e5727eff77ce
Autor:
Shuhe Tsai, Louis-Alexandre Fournier, Emily Yun-Chia Chang, James P Wells, Sean W Minaker, Yi Dan Zhu, Alan Ying-Hsu Wang, Yemin Wang, David G Huntsman, Peter C Stirling
Publikováno v:
PLoS Genetics, Vol 17, Iss 4, p e1009238 (2021)
ARID1A is a core DNA-binding subunit of the BAF chromatin remodeling complex, and is lost in up to 7% of all cancers. The frequency of ARID1A loss increases in certain cancer types, such as clear cell ovarian carcinoma where ARID1A protein is lost in
Externí odkaz:
https://doaj.org/article/330f9ddec6dc43c09ea6f032eae0dc87
Autor:
Aly Karsan, Amit Kumar, Shanks A, Shuhe Tsai, Annie S. Tam, Mathew, Bernard Dg, Peter C. Stirling, Emily Yun-Chia Chang, Docking Tr
Genome instability is a hallmark of cancer that arises through a panoply of mechanisms driven by oncogene and tumour-suppressor gene mutations. Oncogenic mutations in the core splicing factor SF3B1 have been linked to genome instability. Since SF3B1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8ba7ab17da117a0eecfd98fa3ba11a20
https://doi.org/10.1101/2021.05.26.445839
https://doi.org/10.1101/2021.05.26.445839
Autor:
David G. Huntsman, Yemin Wang, Alan Ying-Hsu Wang, Peter C. Stirling, James P. Wells, Yi Dan Zhu, Emily Yun-Chia Chang, Sean W. Minaker, Shuhe Tsai, Louis-Alexandre Fournier
Publikováno v:
PLoS Genetics
PLoS Genetics, Vol 17, Iss 4, p e1009238 (2021)
PLoS Genetics, Vol 17, Iss 4, p e1009238 (2021)
ARID1A is a core DNA-binding subunit of the BAF chromatin remodeling complex, and is lost in up to 7% of all cancers. The frequency of ARID1A loss increases in certain cancer types, such as clear cell ovarian carcinoma where ARID1A protein is lost in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80302d90787bea7c6821ea9e572c10b5
http://europepmc.org/articles/PMC8055027
http://europepmc.org/articles/PMC8055027
Autor:
Arun Kumar, Yan Coulombe, Maria J. Aristizabal, Jean-Yves Masson, Shuhe Tsai, Yi Dan Zhu, Peter C. Stirling, Louis-Alexandre Fournier, Emily Yun-Chia Chang, Philip Hieter, Yujia Alina Chan, Michael S. Kobor, Franciele F. Busatto, Alan Ying-Hsu Wang, James P. Wells
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Nature Communications
Nature Communications
Ectopic R-loop accumulation causes DNA replication stress and genome instability. To avoid these outcomes, cells possess a range of anti-R-loop mechanisms, including RNaseH that degrades the RNA moiety in R-loops. To comprehensively identify anti-R-l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::345515403689908d285f14a420445d7d
https://doi.org/10.1038/s41467-019-12271-w
https://doi.org/10.1038/s41467-019-12271-w