Mice lacking WRB reveal differential biogenesis requirements of tail-anchored proteins in vivo

Autor: Jhon Rivera-Monroy, David P. Corey, Uri Weill, Maya Schuldiner, Anne Clancy, Philipp Ströbel, Javier Coy-Vergara, Kirsten Unthan-Fechner, Sarah Gockel, Tobias Kohl, Fabio Vilardi, Shuh-Yow Lin, Blanche Schwappach, Lena Musiol, Ákos Farkas

Publikováno v: Scientific Reports

Tail-anchored (TA) proteins are post-translationally inserted into membranes. The TRC40 pathway targets TA proteins to the endoplasmic reticulum via a receptor comprised of WRB and CAML. TRC40 pathway clients have been identified using in vitro assay

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efe98af2acabbb5040f10833a797bf83

Tryptophan-rich basic protein (WRB) mediates insertion of the tail-anchored protein otoferlin and is required for hair cell exocytosis and hearing

Autor: Artur A. Indzhykulian, Tobias Moser, Thomas Weber, David P. Corey, Xudong Wu, Elena Cardenas, Ignacio del Castillo, Rosamaria Santarelli, Kelvin Y. Kwan, Iliana Panou, Montserrat Rodríguez-Ballesteros, Carolin Wichmann, Sonja M. Wojcik, SangYong Jung, Christian Vogl, Fabio Vilardi, Shuh-Yow Lin, Gulnara Yamanbaeva, Blanche Schwappach, Nicola Strenzke, Sara J Mangosing, Tina Pangršič

Publikováno v: Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
The EMBO Journal

The transmembrane recognition complex (TRC40) pathway mediates the insertion of tail‐anchored (TA) proteins into membranes. Here, we demonstrate that otoferlin, a TA protein essential for hair cell exocytosis, is inserted into the endoplasmic retic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e4632b151b611e64d42ee531c07c5e3
https://hdl.handle.net/20.500.12530/25768

Insertional mutagenesis in zebrafish rapidly identifies genes essential for early vertebrate development

Autor: Zhaoxia Sun, Marcelo Antonelli, Nancy Hopkins, Shawn M. Burgess, Robert M. Nissen, Sarah Farrington, Shuh-Yow Lin, Gregory Golling, Adam Amsterdam, Wenbiao Chen, Maryann Haldi, Ernesto Maldonado, Karen Artzt

Publikováno v: Nature Genetics. 31:135-140

To rapidly identify genes required for early vertebrate development, we are carrying out a large-scale, insertional mutagenesis screen in zebrafish, using mouse retroviral vectors as the mutagen. We will obtain mutations in 450 to 500 different genes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20c8b82f4caa2fd7238ffb681ee766e7
https://doi.org/10.1038/ng896

Ecrg4 expression and its product augurin in the choroid plexus: impact on fetal brain development, cerebrospinal fluid homeostasis and neuroprogenitor cell response to CNS injury

Autor: Shuh-Yow Lin, Stuart Knowling, Brian P. Eliceiri, Edward G. Stopa, Sonia Podvin, Raul Coimbra, Elena Cardenas-Galindo, Ana Maria Gonzalez, Conrad E. Johanson, Andrew Baird, Hannah Botfield, Xitong Dang, Wendy Leadbeater, John E. Donahue, Andrew Roberton, Miles C. Miller

Publikováno v: Fluids and Barriers of the CNS
Gonzalez, AM; Podvin, S; Lin, SY; Miller, MC; Botfield, H; Leadbeater, WE; et al.(2011). Ecrg4 expression and its product augurin in the choroid plexus: Impact on fetal brain development, cerebrospinal fluid homeostasis and neuroprogenitor cell response to CNS injury. Fluids and Barriers of the CNS, 8(1). doi: 10.1186/2045-8118-8-6. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/1v12b7rj
Fluids and Barriers of the CNS, Vol 8, Iss 1, p 6 (2011)
Gonzalez, Ana; Podvin, Sonia; Lin, Shuh-Yow; Miller, Miles C; Botfield, Hannah; Leadbeater, Wendy E; et al.(2011). Ecrg4 expression and its product augurin in the choroid plexus: impact on fetal brain development, cerebrospinal fluid homeostasis and neuroprogenitor cell response to CNS injury. Fluids and Barriers of the CNS, 8(1), 6. doi: http://dx.doi.org/10.1186/2045-8118-8-6. Retrieved from: http://www.escholarship.org/uc/item/3kp62388

Background The content and composition of cerebrospinal fluid (CSF) is determined in large part by the choroid plexus (CP) and specifically, a specialized epithelial cell (CPe) layer that responds to, synthesizes, and transports peptide hormones into

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2ac2be7127ec34ff983c39632fa05af
https://pubmed.ncbi.nlm.nih.gov/21349154

Suppression of Sprouting: An Early Function of NMDA Receptors in the Absence of AMPA/Kainate Receptor Activity

Autor: Shuh-Yow Lin, Martha Constantine-Paton

Electrophysiological studies have documented the existence of synapses showing only NMDA ionotropic glutamate receptor function that are therefore presumably “silent” at resting membrane potentials. Silent synapses are more prevalent in young tha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5181b669893203540c684b4b89752689
https://europepmc.org/articles/PMC6793148/