Zobrazeno 1 - 10
of 819
pro vyhledávání: '"Shuh Narumiya"'
Autor:
Mina Tanabe, Kanako Hosono, Atsushi Yamashita, Yoshiya Ito, Masataka Majima, Shuh Narumiya, Chika Kusano, Hideki Amano
Publikováno v:
Inflammation and Regeneration, Vol 44, Iss 1, Pp 1-20 (2024)
Abstract Background Acetaminophen (APAP)-induced liver injury is the most common cause of acute liver failure. Macrophages are key players in liver restoration following APAP-induced liver injury. Thromboxane A2 (TXA2) and its receptor, thromboxane p
Externí odkaz:
https://doaj.org/article/56eba43030bc47038f788f4559bdff56
Autor:
Takahiro Akamine, Takeshi Terabayashi, Takako Sasaki, Riku Hayashi, Ichitaro Abe, Fumihiro Hirayama, Shin‐ichi Nureki, Masahito Ikawa, Haruhiko Miyata, Akinori Tokunaga, Takashi Kobayashi, Katsuhiro Hanada, Dean Thumkeo, Shuh Narumiya, Toshimasa Ishizaki
Publikováno v:
FEBS Open Bio, Vol 14, Iss 6, Pp 906-921 (2024)
The Ras homology (Rho) family of GTPases serves various functions, including promotion of cell migration, adhesion, and transcription, through activation of effector molecule targets. One such pair of effectors, the Rho‐associated coiled‐coil kin
Externí odkaz:
https://doaj.org/article/55c8cc91eaf9494c8af4f125e026844e
Autor:
Ashton L. Sigler, Scott B. Thompson, Logan Ellwood-Digel, Adithan Kandasamy, Mary J. Michaels, Dean Thumkeo, Shuh Narumiya, Juan C. Del Alamo, Jordan Jacobelli
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Lymphocyte trafficking and migration through tissues is critical for adaptive immune function and, to perform their roles, T cells must be able to navigate through diverse tissue environments that present a range of mechanical challenges. T cells pre
Externí odkaz:
https://doaj.org/article/8d8a242143d24c529f8431db63d56272
Autor:
Shinsuke Nakamura, Rie Yamamoto, Takaya Matsuda, Hiroto Yasuda, Anri Nishinaka, Kei Takahashi, Yuki Inoue, Sadao Kuromitsu, Masamitsu Shimazawa, Masahide Goto, Shuh Narumiya, Hideaki Hara
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract Ocular abnormal angiogenesis and edema are featured in several ocular diseases. S1P signaling via S1P1 likely is part of the negative feedback mechanism necessary to maintain vascular health. In this study, we conducted pharmacological exper
Externí odkaz:
https://doaj.org/article/b3f0c584a6654d6986335acb20a55dc8
Autor:
Tetsuya Watabe, Shinya Yamahira, Kanako Takakura, Dean Thumkeo, Shuh Narumiya, Michiyuki Matsuda, Kenta Terai
Publikováno v:
eLife, Vol 12 (2024)
Prostaglandin E2 (PGE2) is a key player in a plethora of physiological and pathological events. Nevertheless, little is known about the dynamics of PGE2 secretion from a single cell and its effect on the neighboring cells. Here, by observing confluen
Externí odkaz:
https://doaj.org/article/150e6e73c8384e599c47c581550169ca
Autor:
Namiko Kawamura, Goro Katsuura, Nobuko Yamada-Goto, Riho Nakama, Yuki Kambe, Atsuro Miyata, Tomoyuki Furuyashiki, Shuh Narumiya, Yoshihiro Ogawa, Akio Inui
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Fractalkine is one of the CX3C chemokine family, and it is widely expressed in the brain including the hypothalamus. In the brain, fractalkine is expressed in neurons and binds to a CX3C chemokine receptor 1 (CX3CR1) in microglia. The hypoth
Externí odkaz:
https://doaj.org/article/eba01d4f3e5848ca91b25ba5bd2380da
Publikováno v:
STAR Protocols, Vol 3, Iss 4, Pp 101906- (2022)
Summary: Here, we describe a protocol for single-cell isolation from the primary culture of normal human epidermal keratinocytes derived from neonatal foreskin. The cell culture conditions have been optimized for inducing expression of keratinocyte d
Externí odkaz:
https://doaj.org/article/c207a63beeaf40e28b314f36c206ddd9
Autor:
Ratklao Siriwach, Anh Quynh Ngo, Makio Higuchi, Kentaro Arima, Satoko Sakamoto, Akira Watanabe, Shuh Narumiya, Dean Thumkeo
Publikováno v:
iScience, Vol 25, Iss 4, Pp 104130- (2022)
Summary: Keratinocyte differentiation is an intricate process that is regulated by multiple mediators. Using cultured human keratinocytes, we found that lysophosphatidic acid (LPA) induced the differentiation of a previously unsuspected keratinocyte
Externí odkaz:
https://doaj.org/article/97cf8e5bf9d5453188f35d32b6dbfe81
Autor:
Xiang Nie, Shiho Kitaoka, Masakazu Shinohara, Akira Kakizuka, Shuh Narumiya, Tomoyuki Furuyashiki
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
Abstract Inflammation in the brain and periphery has been associated with stress-related pathology of mental illness. We have shown that prostaglandin (PG) E2, an arachidonic acid-derived lipid mediator, and innate immune receptors Toll-like receptor
Externí odkaz:
https://doaj.org/article/60260c3f54e345d4b0c7bfbf9609e0e9
Autor:
Tomohiro Aoki, Hirokazu Koseki, Haruka Miyata, Masayoshi Itoh, Hideya Kawaji, Katsumi Takizawa, Akitsugu Kawashima, Hiroshi Ujiie, Takashi Higa, Kenzo Minamimura, Toshikazu Kimura, Hidetoshi Kasuya, Kazuhiko Nozaki, Akio Morita, Hirotoshi Sano, Shuh Narumiya
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-8 (2019)
Abstract Intracranial aneurysm (IA) is a socially important disease as a major cause of subarachnoid hemorrhage. Recent experimental studies mainly using animal models have revealed a crucial role of macrophage-mediated chronic inflammatory responses
Externí odkaz:
https://doaj.org/article/42132f10b4824a308c245646ef9a229d