Zobrazeno 1 - 10
of 121
pro vyhledávání: '"Shuguang, Tan"'
Autor:
Dan Lu, Yuan Chen, Min Jiang, Jie Wang, Yiting Li, Keke Ma, Wenqiao Sun, Xing Zheng, Jianxun Qi, Wenjing Jin, Yu Chen, Yan Chai, Catherine W. H. Zhang, Hao Liang, Shuguang Tan, George F. Gao
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract KRAS mutations are broadly recognized as promising targets for tumor therapy. T cell receptors (TCRs) can specifically recognize KRAS mutant neoantigens presented by human lymphocyte antigen (HLA) and mediate T cell responses to eliminate tu
Externí odkaz:
https://doaj.org/article/00331b97b91648df80cce9b53c476ee3
Autor:
Jiawei Guan, Hongchuan Liu, Yan Chai, Jie Yu, Jian Yao, Jing Wang, Zhiwei Pan, Jing Zhang, Yuehua Zhou, Hui Liu, Sheng Yao, Jianxun Qi, Hui Feng, George F. Gao, Qihui Wang, Yi Shi, Shuguang Tan
Publikováno v:
mAbs, Vol 15, Iss 1 (2023)
ABSTRACTCytotoxic T lymphocyte-associated antigen 4 (CTLA-4) is a critical inhibitory checkpoint molecule, and monoclonal antibodies (mAbs) targeting CTLA-4 that restore anti-tumor T cell immunity have achieved clinical success. Here, we report a hum
Externí odkaz:
https://doaj.org/article/a7f6d01c43cd47519759b8c736f47447
Autor:
Weiyu Peng, Xiaopeng Ma, Kun Tan, Hongmei Wang, Mengqing Cong, Yanan Zhang, Shuguang Tan, Xin Zhao, George F. Gao, Jikui Deng
Publikováno v:
The Lancet Regional Health. Western Pacific, Vol 40, Iss , Pp 100939- (2023)
Externí odkaz:
https://doaj.org/article/647af8148e4844fb9aff4362cbbb0672
Autor:
Kefang Liu, Yumin Meng, Yan Chai, Linjie Li, Huan Sun, George F. Gao, Shuguang Tan, Jianxun Qi
Publikováno v:
Biosafety and Health, Vol 3, Iss 2, Pp 116-123 (2021)
African swine fever virus (ASFV) is the causative agent of African swine fever, a highly fatal hemorrhagic disease of pigs, which has resulted in great economic losses to the global pork industry, especially in Asia. ASFV particles are comprised of m
Externí odkaz:
https://doaj.org/article/aaed75cb092c40608a1d6678a27d07cf
A single-dose mRNA vaccine provides a long-term protection for hACE2 transgenic mice from SARS-CoV-2
Autor:
Qingrui Huang, Kai Ji, Siyu Tian, Fengze Wang, Baoying Huang, Zhou Tong, Shuguang Tan, Junfeng Hao, Qihui Wang, Wenjie Tan, George F. Gao, Jinghua Yan
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
Several mRNA-based vaccines for SARS-CoV-2 are in late phase clinical development. Here, the authors show that a single immunization with a mRNA vaccine expressing SARS-CoV-2 spike RBD induces neutralizing antibodies that are maintained for at least
Externí odkaz:
https://doaj.org/article/e37e0ac7b8024061a8bb32d1d7084a2e
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
EphA2 is the specific entry receptor for both human γ-herpesviruses Kaposi sarcoma associated herpesvirus (KSHV) and Epstein-Barr virus (EBV). Here, the authors present the crystal structures of the EphA2 ligand binding domain (LBD) bound to the vir
Externí odkaz:
https://doaj.org/article/ac26222e07064a76b8a070ea9eb86d83
Autor:
Huan Sun, Yan Li, Peipei Liu, Chengpeng Qiao, Xiaomin Wang, Lianao Wu, Kefang Liu, Yu Hu, Chao Su, Shuguang Tan, Shumei Zou, Guizhen Wu, Jinghua Yan, George Fu Gao, Jianxun Qi, Qihui Wang
Publikováno v:
Emerging Microbes and Infections, Vol 9, Iss 1, Pp 1238-1241 (2020)
Externí odkaz:
https://doaj.org/article/402e2fca220042c09587b79e8492cfae
Autor:
Dan Lu, Zepeng Xu, Ding Zhang, Min Jiang, Kefang Liu, Juanhua He, Dongli Ma, Xiaopeng Ma, Shuguang Tan, George F. Gao, Yan Chai
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Immune checkpoint therapy (ICT) with a monoclonal antibody (MAb) against programmed cell death protein 1 (PD-1) is a powerful clinical treatment for tumors. Cemiplimab is a human IgG4 antibody approved in 2018 and is the first MAb proven to be effect
Externí odkaz:
https://doaj.org/article/b2bd4346417a4d0d8fd42bacf83103ea
Publikováno v:
iScience, Vol 24, Iss 10, Pp 103190- (2021)
Summary: Human trophoblast cell surface antigen 2 (TROP-2) is an important target of tumor therapy, and antibody-drug conjugates with sacituzumab targeting TROP-2 have been approved for the treatment of triple-negative breast cancer. Here, we report
Externí odkaz:
https://doaj.org/article/539bec5288e94fe99f640be42ea37f47
Autor:
Hangjie Zhang, Wenling Xiao, Min Zhao, Yingze Zhao, Yongli Zhang, Dan Lu, Shuangshuang Lu, Qingxu Zhang, Weiyu Peng, Liumei Shu, Jie Zhang, Sai Liu, Kexin Zong, Pengyan Wang, Beiwei Ye, Shihua Li, Shuguang Tan, Fuping Zhang, Jianfang Zhou, Peipei Liu, Guizhen Wu, Xuancheng Lu, George F. Gao, William J. Liu
Publikováno v:
Viruses, Vol 14, Iss 11, p 2332 (2022)
Zika virus (ZIKV)-specific T cells are activated by different peptides derived from virus structural and nonstructural proteins, and contributed to the viral clearance or protective immunity. Herein, we have depicted the profile of CD8+ and CD4+ T ce
Externí odkaz:
https://doaj.org/article/711bdf2d4b59425ea6e9215c3ed0155c