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Akademický článek

Bcl10 Links Saturated Fat Overnutrition with Hepatocellular NF-κB Activation and Insulin Resistance

Autor: Matthew Van Beek, Katherine I. Oravecz-Wilson, Phillip C. Delekta, Shufang Gu, Xiangquan Li, Xiaohong Jin, Ingrid J. Apel, Katy S. Konkle, Yongjia Feng, Daniel H. Teitelbaum, Jürgen Ruland, Linda M. McAllister-Lucas, Peter C. Lucas

Publikováno v: Cell Reports, Vol 1, Iss 5, Pp 444-452 (2012)

Excess serum free fatty acids (FFAs) are fundamental to the pathogenesis of insulin resistance. With high-fat feeding, FFAs activate NF-κB in target tissues, initiating negative crosstalk with insulin signaling. However, the mechanisms underlying FF

Externí odkaz: https://doaj.org/article/b293056fede5440aa011fb0418d15fea

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MALT1 Protease Activation Triggers Acute Disruption of Endothelial Barrier Integrity via CYLD Cleavage

Autor: Dong Hu, Peter C. Lucas, Emily M. Hess, Linda R. Klei, Katherine Oravecz-Wilson, Kevin Foley, Linda M. McAllister-Lucas, Vincent J. Concel, Robert L. Panek, Rachel E. Bridwell, Matthew Van Beek, Simon C. Watkins, Phillip C. Delekta, Peter J. Gough, Shufang Gu, Adrian T. Ting, Kelly M. Bailey, Danielle N. Alfano, John Bertin

Publikováno v: Cell Reports, Vol 17, Iss 1, Pp 221-232 (2016)

SummaryMicrovascular endothelial cells maintain a tight barrier to prevent passage of plasma and circulating immune cells into the extravascular tissue compartment, yet endothelial cells respond rapidly to vasoactive substances, including thrombin, a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6fc00515520320ccc4a460e48a1608f
https://doi.org/10.1016/j.celrep.2016.08.080

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Bcl10 links saturated fat overnutrition with hepatocellular NF-kB activation and insulin resistance

Autor: Daniel H. Teitelbaum, Xiangquan Li, Xiaohong Jin, Katy S. Konkle, Shufang Gu, Phillip C. Delekta, Katherine Oravecz-Wilson, Jürgen Ruland, Yongjia Feng, Peter C. Lucas, Matthew Van Beek, Ingrid J. Apel, Linda M. McAllister-Lucas

Publikováno v: Cell Reports, 1, 5, pp. 444-52
Cell Rep. 1, 444-452 (2012)
Cell Reports, Vol 1, Iss 5, Pp 444-452 (2012)
Cell Reports, 1, 444-52

Contains fulltext : 110369.pdf (author's version ) (Open Access) Excess serum free fatty acids (FFAs) are fundamental to the pathogenesis of insulin resistance. With high-fat feeding, FFAs activate NF-kB in target tissues, initiating negative crossta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d2b922312e2d08ed303fbf36095701b
https://hdl.handle.net/2066/110369

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Thrombin-dependent NF-κB Activation and Monocyte/Endothelial Adhesion Are Mediated by the CARMA3·Bcl10·MALT1 Signalosome

Autor: Linda M. McAllister-Lucas, Yoshiyuki Hattori, Katy Siu, Phillip C. Delekta, Shufang Gu, Ingrid J. Apel, Peter C. Lucas

Publikováno v: Journal of Biological Chemistry. 285:41432-41442

Thrombin is a potent modulator of endothelial function and, through stimulation of NF-κB, induces endothelial expression of intracellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1). These cell surface adhesion molecu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::720ee339a2788bb17963dc3109f85192
https://doi.org/10.1074/jbc.m110.158949

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HIF1-alpha Regulates Acinar Cell Function and Response to Injury in Mouse Pancreas

Autor: Steven W. Pipe, Diane M. Simeone, M. Bishr Omary, Sapna Iyer, Min-Jung Park, Shufang Gu, Xiang Xue, Juliana Bragazzi Cunha, David S. Moons, John A. Williams, Yatrik M. Shah

Publikováno v: Gastroenterology. 154:1630-1634.e3

We investigated whether intrapancreatic coagulation, with deposition of the fibrinogen-γ dimer (Fib-γD) and hypoxia, affect the severity of acute pancreatitis (AP) in mice. Pancreata of mice with AP induced by administration of cerulein or by L-arg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37798eb5abc3f883026a0cc3381d5084
https://doi.org/10.1053/j.gastro.2018.01.037

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A dual role for the API2 moiety in API2-MALT1-dependent NF-κB activation: heterotypic oligomerization and TRAF2 recruitment

Autor: Xiaohong Jin, J Swenson, Peter Kuffa, Peter C. Lucas, Dawn Kohrt, David S.L. Kim, Linda M. McAllister-Lucas, Katy Siu, Shufang Gu

Publikováno v: Oncogene. 26:5643-5654

Mucosa-associated lymphoid tissue (MALT) lymphoma is the most common extranodal lymphoid neoplasm. Chromosomal translocation t(11;18)(q21,q21) is found in 30% of gastric MALT lymphomas and is associated with a failure to respond to standard treatment

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c086f70b1d02a3840c032531b077a44
https://doi.org/10.1038/sj.onc.1210342

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A von Willebrand factor fragment containing the D'D3 domains is sufficient to stabilize coagulation factor VIII in mice

Autor: Colin A. Kretz, Shufang Gu, Andrew Yee, Keisha M. Carr, Beth McGee, Steven W. Pipe, Robert D. Gildersleeve, David Ginsburg

Publikováno v: Blood. 124(3)

Plasma factor VIII (FVIII) and von Willebrand factor (VWF) circulate together as a complex. We identify VWF fragments sufficient for FVIII stabilization in vivo and show that hepatic expression of the VWF D'D3 domains (S764-P1247), either as a monome

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed2081ba458070d28413589177afcfb3
https://pubmed.ncbi.nlm.nih.gov/25035147

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The CARMA3-Bcl10-MALT1 signalosome promotes angiotensin II-dependent vascular inflammation and atherogenesis

Autor: Scott Rp McDonnell, Matthew Van Beek, Linda M. McAllister-Lucas, Phillip C. Delekta, Shufang Gu, Katy Siu, Peter C. Lucas, Xiaohong Jin, Jürgen Ruland

Publikováno v: J. Biol. Chem. 285, 25880-25884 (2010)

The CARMA1, Bcl10, and MALT1 proteins together constitute a signaling complex (CBM signalosome) that mediates antigen-dependent activation of NF-kappaB in lymphocytes, thereby representing a cornerstone of the adaptive immune response. Although CARMA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cb4f5a15fffbc6fefeb2363ea9e65b2
https://pubmed.ncbi.nlm.nih.gov/20605784

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CARMA3/Bcl10/MALT1-dependent NF-kappaB activation mediates angiotensin II-responsive inflammatory signaling in nonimmune cells

Autor: Katy Siu, Tak W. Mak, Xiaohong Jin, Dawn Kohrt, Peter C. Lucas, Peter Kuffa, Shufang Gu, Gabriel Núñez, David S.L. Kim, Linda M. McAllister-Lucas, Jürgen Ruland

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America. 104(1)

Angiotensin II (Ang II) is a peptide hormone that, like many cytokines, acts as a proinflammatory agent and growth factor. After injury to the liver, the hormone assists in tissue repair by stimulating hepatocytes and hepatic stellate cells to synthe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52fcef17545a90654a9e0b1e08025945
https://pubmed.ncbi.nlm.nih.gov/17101977

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