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The Third Generation Anti-HER2 Chimeric Antigen Receptor Mouse T Cells Alone or Together With Anti-PD1 Antibody Inhibits the Growth of Mouse Breast Tumor Cells Expressing HER2 in vitro and in Immune Competent Mice

Autor: Panyuan Li, Lingcong Yang, Tong Li, Shufang Bin, Bohao Sun, Yuting Huang, Kaiyan Yang, Daming Shan, Haihua Gu, Hongzhi Li

Publikováno v: Frontiers in Oncology, Vol 10 (2020)

Chimeric Antigen Receptor (CAR)-T cells have great efficacy against CD19+ leukemia but little success for solid tumors. This study explored the effectiveness of third generation anti-HER2 CAR-T cells alone or in combination with anti-PD1 antibody on

Externí odkaz: https://doaj.org/article/fce77531ae3a41a586cd38cedfb40a2e

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The Third Generation Anti-HER2 Chimeric Antigen Receptor Mouse T Cells Alone or Together With Anti-PD1 Antibody Inhibits the Growth of Mouse Breast Tumor Cells Expressing HER2

Autor: Haihua Gu, Bohao Sun, Hongzhi Li, Panyuan Li, Daming Shan, Kaiyan Yang, Tong Li, Lingcong Yang, Shufang Bin, Yuting Huang

Publikováno v: Frontiers in Oncology
Frontiers in Oncology, Vol 10 (2020)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15d42e68eba1b7b2bea656a43c5098c1
https://pubmed.ncbi.nlm.nih.gov/32766150

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The efficacy of third generation anti‑HER2 chimeric antigen receptor T cells in combination with PD1 blockade against malignant glioblastoma cells

Autor: Hongzhi Li, Panyuan Li, Haihua Gu, Jie Chen, Shufang Bin, Luxi Shen, Weihua Yuan

Publikováno v: Oncology reports. 42(4)

Without effective treatment, glioblastoma is one of the deadliest cancers worldwide. The aim of the present study was to explore whether combinational immunotherapy is effective for treating malignant glioblastoma in vitro. The therapeutic efficacy o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ce6662f5c209f68a61a50c209a499e8
https://pubmed.ncbi.nlm.nih.gov/31524276

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Comparative analysis and optimization of protocols for producing recombinant lentivirus carrying the anti-Her2 chimeric antigen receptor gene

Autor: Lingcong Yang, Shufang Bin, Jie Chen, Ying Cao, Qi Bian, Weihua Yuan, Hezhi Fang, Panyuan Li, Hongzhi Li, Luxi Shen, Jiawei Cao, Haihua Gu

Publikováno v: The journal of gene medicine. 20(7-8)

Background The production of anti-Her2 chimeric antigen receptor (CAR) T cells needs to be optimized to make it a reliable therapy. Methods Three types of lentiviral vectors expressing anti-Her2 CAR together with packaging plasmids were co-transfecte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19825355b7d3f8e6d48e340e5acb7021
https://pubmed.ncbi.nlm.nih.gov/29851200

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