Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Shuet Hing Lee Chiu"'
Autor:
Su-Er W. Huskey, Ray Bakhtiar, Deborah J. Newton, David C. Evans, Ping Lu, Regina W. Wang, Rosa I. Sanchez, Shuet-Hing Lee Chiu
Publikováno v:
Drug Metabolism and Disposition. 32:1287-1292
The contribution of human cytochrome P450 (P450) isoforms to the metabolism of aprepitant in humans was investigated using recombinant P450s and inhibition studies. In addition, aprepitant was evaluated as an inhibitor of human P450s. Metabolism of a
Autor:
Ann Mao, Tony Pereira, Paul G. Pearson, Shuet-Hing Lee Chiu, Christopher J. Kochansky, Maria G. Beconi, David Q. Liu, Conrad E. Raab
Publikováno v:
Drug Metabolism and Disposition. 31:1269-1277
The pharmacokinetics and metabolism of the l-threo isoleucine thiazolidide dipeptidyl peptidase IV inhibitor, di-[2S,3S]-2-amino-3-methyl-pentanoic-1,3-thiazolidine fumarate (ILT-threo) and its allo stereoisomer (ILT-allo) were evaluated in rats, dog
Autor:
Carol Ann Keohane, Gloria Y. Kwei, Wei Tang, Susan A. Iliff, Adria Colletti, Vincent J. Colandrea, Frank S. Tang, Ann E. Weber, Randy R. Miller, Shuet-Hing Lee Chiu, William P. Feeney, Ralph A. Stearns, John R. Strauss, Dawn Chitty, Elizabeth M. Naylor, Robert J. Mathvink
Publikováno v:
Drug Metabolism and Disposition. 30:771-777
The pharmacokinetics and oral bioavailability of (R)-N-[4-[2-[[2-hydroxy-2-(pyridin-3-yl)ethyl]amino]ethyl]phenyl]-4-[4-[4-(trifluoromethylphenyl]thiazol-2-yl]benzenesulfonamide (1), a 3-pyridyl thiazole benzenesulfonamide beta3-adrenergic receptor a
Publikováno v:
Rapid Communications in Mass Spectrometry. 15:1832-1839
An Erratum for this article has been published in Rapid Communications in Mass Spectrometry 17(3) 2003, 264 Biotransformation studies performed on an investigational compound (I, represented by R1-CH(NH2)-CO-N(R2)-CH2-S-R3) led to the identification
Publikováno v:
Rapid Communications in Mass Spectrometry. 15:2135-2144
A method with parallel extraction columns and parallel analytical columns (PEC-PAC) for on-line high-flow liquid chromatography/tandem mass spectrometry (LC/MS/MS) was developed and validated for simultaneous quantification of a drug candidate and it
Autor:
Ann E. Weber, Thomas L. Shih, Michael J. Forrest, Randall R. Miller, Michael H. Fisher, Matthew J. Wyvratt, Catherine D. Strader, Margaret A. Cascieri, Liping Deng, Ralph A. Stearns, D. Euan MacIntyre, William P. Feeney, Mari R. Candelore, Gary J Hom, Lawrence F. Colwell, Laurie Tota, Shuet-Hing Lee Chiu
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 9:1251-1254
L-770,644 (9c) is a potent and selective agonist of the human β3 adrenergic receptor (EC50 = 13 nM). It shows good oral bioavailability in both dogs and rats (%F = 27), and is a full agonist for glycerolemia in the rhesus monkey (ED50 = 0.21 mg/kg).
Autor:
Nancy N. Tsou, Liente Wei, Zhijian Lu, Gerard J. Hickey, Roy G. Smith, Klaus D. Schleim, James R. Tata, Kwan Leung, Arthur A. Patchett, Shuet-Hing Lee Chiu, Wanda W.-S. Chan, Thomas M. Jacks, Bridget Butler, Kang Cheng
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 7:2319-2324
The design, synthesis, and activities of a series of short duration spiroindane growth hormone secretagogues are reported. Incorporation of a readily metabolized ester into the spiroindane benzylic position provided a series of highly potent orally a
Autor:
Henry T. Meriwether, Avery Rosegay, Marilyn L. Green, Diana Eline, Theodore A. Jacob, Shuet Hing Lee Chiu, Francis P. Baylis
Publikováno v:
Journal of Agricultural and Food Chemistry. 38:2072-2078
Tritium-labeled ivermectin was studied in cattle, sheep, and rat for absorption, tissue residue distribution, and excretion at doses of 0.3 mg/kg of body weight. The drug was absorbed by various dosing routes. By intraruminal and subcutaneous dosing
Autor:
Marilyn L. Green, E. Sestokas, Rae Taub, Shuet Hing Lee Chiu, Theodore A. Jacob, Anthony Y.H. Lu, Francis P. Baylis
Publikováno v:
Journal of Agricultural and Food Chemistry. 38:2079-2085
Tissue residue distribution and metabolism of tritium-labeled ivermectin have been studied in swine dosed subcutaneously at 0.4 mg/kg of body weight. The residue distribution pattern among edible tissues (liver, kidney, muscle, and fat) was similar t
Publikováno v:
Drug Metabolism Reviews. 22:891-904