Výsledky vyhledávání

SAR of Carbon-Linked, 2-Substituted Purines: Synthesis and Characterization of AP23451 as a novel Bone-Targeted Inhibitor of Src Tyrosine Kinase With In Vivo Anti-Resorptive Activity

Publikováno v: Chemical Biology & Drug Design. 71:97-105

Targeted disruption of the pp60(src) (Src) gene has implicated this tyrosine kinase in osteoclast-mediated bone resorption and as a therapeutic target for the treatment of osteoporosis and other bone-related diseases. Here, we describe structure acti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dcdeae0a92758c4ad04f2c1f5760a13
https://doi.org/10.1111/j.1747-0285.2007.00615.x

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Bone-Targeted pyrido[2,3-d]pyrimidin-7-ones: potent inhibitors of Src tyrosine kinase as novel antiresorptive agents

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 13:3071-3074

The design of bone-targeted pyrido[2,3-d]pyrimidin-7-ones as Src tyrosine kinase inhibitors is described. Leveraging SAR from known compounds and using structure-based methods, we were able to rapidly incorporate bone binding components, which mainta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::557b75ac7c90bb0fb12e38e1f0a1e1cc
https://doi.org/10.1016/s0960-894x(03)00649-8

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Bone-targeted Src kinase inhibitors: novel pyrrolo- and pyrazolopyrimidine analogues

Publikováno v: Bioorganicmedicinal chemistry letters. 13(18)

Src tyrosine kinase is a therapeutic target for bone diseases that has been validated by gene knockout studies. Furthermore, in vitro cellular studies implicate that Src has a positive regulatory role in osteoclasts and a negative regulatory role in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f0025c9bb833a7a24ceb965cc177fad
https://pubmed.ncbi.nlm.nih.gov/12941334

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Bone-targeted 2,6,9-trisubstituted purines: novel inhibitors of Src tyrosine kinase for the treatment of bone diseases

Autor: Chester A. Metcalf, Ukti Mani, Shiela M. Violette, Tomi K. Sawyer, Susan Adams, Yihan Wang, Terence P. Keenan, Regine S. Bohacek, Marie Rose van Schravendijk, Mary K. Ram, David C. Dalgarno, Selvi Pradeepan, Raji Sundaramoorthi, William C. Shakespeare, Jeffrey A. Keats, Surinder S. Narula, Chad Haraldson, Manfred Weigele, Shuenn Liou

Publikováno v: Bioorganicmedicinal chemistry letters. 13(18)

Novel bone-targeted 2,6,9-trisubstituted purine template-based inhibitors of Src tyrosine kinase are described. Drug design studies of known purine compounds revealed that both positions-2 and -6 were suitable for incorporating bone-seeking moieties.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75987963f2540aebe25650862e108230
https://pubmed.ncbi.nlm.nih.gov/12941335

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Radicicol, a protein tyrosine kinase inhibitor, suppresses the expression of mitogen-inducible cyclooxygenase in macrophages stimulated with lipopolysaccharide and in experimental glomerulonephritis

Autor: Minoru Yoshida, Teruhiko Beppu, Jong H. Lee, Shuenn Liou, Daniel H. Hwang, Mary D. Boudreau, Curtis B. Wilson, Ho J. Kwon, Gang Yu, Prithiva Chanmugam, Yiyang Xia, Lili Feng, Byeong C. Jang

Publikováno v: The Journal of biological chemistry. 270(10)

Two isoforms of cyclooxygenase (COX) have been identified in eukaryotic cells: a constitutively expressed COX-1 and mitogen-inducible COX-2, which is selectively expressed in response to various inflammatory stimuli. Thus, COX-2 instead of COX-1 is i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bc3b6bb6b1c34e4f6c0c37db84b7c16
https://pubmed.ncbi.nlm.nih.gov/7890656

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Dissertation/ Thesis

Influence of Carbon and Nitrogen Sources on Carbon-Nitrogen Metabolism for Soybean [Glycine max (L.) Merr.] Callus

Autor: Jin-Shuenn Liou, 劉金順

83
Three kinds of callus induced from soybean leaf, hypocotyl and root, were subjected to different carbon and nitrogen sources to investigate the effect on carbon-nitrogen metabolism. The results are summarized as follows: The net photosyntheti

Externí odkaz: http://ndltd.ncl.edu.tw/handle/19127680361302003480

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Selective expression of mitogen-inducible cyclooxygenase in macrophages stimulated with lipopolysaccharide

Autor: Shuenn Liou, Suzanne B. Hart, Hua Zhong, Emmanuel Soyoola, Soo H. Lee, Daniel Simmons, Daniel H. Hwang, Prithiva Chanmugam, Wenqin Sun

Publikováno v: The Journal of biological chemistry. 267(36)

Two forms of cyclooxygenase are known to be present in eukaryotic organisms: a cyclooxygenase (COX-1) first purified from ram seminal vesicles encoded by a 2.8-kilobase mRNA, and a newly discovered mitogen-inducible cyclooxygenase (COX-2) encoded by

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f25610f26c22e42585c5c22efb2dd287
https://pubmed.ncbi.nlm.nih.gov/1464605

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Corrigendum to 'Bone-Targeted Src Kinase Inhibitors: Novel Pyrrolo- and Pyrazolopyrimidine Analogues'[Bioorg. Med. Chem. Lett. 13 (2003) 3063]

Autor: Regine Bohacek, Raji Sundaramoorthi, Shuenn Liou, Taylor Merry, Surinder S. Narula, David C. Dalgarno, Mary K. Ram, Terence P. Keenan, Chester A. Metcalf, Shuangying Liu, Ukti N. Mani, Shelia Violette, Susan Adams, Jeffrey A. Keats, Yihan Wang, Marie Rose van Schravendijk, Manfred Weigle, Tomi K. Sawyer, William C. Shakespeare

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 13:4519

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ebf24f2e7962dd0357a2297bb9c007f1
https://doi.org/10.1016/j.bmcl.2003.09.017

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