Výsledky vyhledávání - "Shuenn‐Chen Yang"

Akademický článek

Development of nanoparticles incorporated with quercetin and ACE2-membrane as a novel therapy for COVID-19

Autor: Jia-You Fang, Kuo-Yen Huang, Tong-Hong Wang, Zih-Chan Lin, Chin-Chuan Chen, Sui-Yuan Chang, En-Li Chen, Tai-Ling Chao, Shuenn-Chen Yang, Pan-Chyr Yang, Chi-Yuan Chen

Publikováno v: Journal of Nanobiotechnology, Vol 22, Iss 1, Pp 1-15 (2024)

Abstract Introduction Angiotensin-converting enzyme 2 (ACE2) and AXL tyrosine kinase receptor are known to be involved in the SARS-CoV-2 entry of the host cell. Therefore, targeting ACE2 and AXL should be an effective strategy to inhibit virus entry

Externí odkaz: https://doaj.org/article/d499e64a4ae440dfafb7c71ebdd6ef48

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Akademický článek

PM2.5 promotes lung cancer progression through activation of the AhR‐TMPRSS2‐IL18 pathway

Autor: Tong‐Hong Wang, Kuo‐Yen Huang, Chin‐Chuan Chen, Ya‐Hsuan Chang, Hsuan‐Yu Chen, Chuen Hsueh, Yi‐Tsen Liu, Shuenn‐Chen Yang, Pan‐Chyr Yang, Chi‐Yuan Chen

Publikováno v: EMBO Molecular Medicine, Vol 15, Iss 6, Pp 1-16 (2023)

Abstract Particulate matter 2.5 (PM2.5) is a risk factor for lung cancer. In this study, we investigated the molecular mechanisms of PM2.5 exposure on lung cancer progression. We found that short‐term exposure to PM2.5 for 24 h activated the EGFR p

Externí odkaz: https://doaj.org/article/5e9ebe0cfc3745a7aea86a1c3a1d3ea3

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Akademický článek

Monocarboxylate Transporter 4 Is a Therapeutic Target in Non-small Cell Lung Cancer with Aerobic Glycolysis Preference

Autor: Ting-Chun Kuo, Kuo-Yen Huang, Shuenn-Chen Yang, Sean Wu, Wei-Chia Chung, Yih-Leong Chang, Tse-Ming Hong, Shu-Ping Wang, Hsuan-Yu Chen, Tzu-Hung Hsiao, Pan-Chyr Yang

Publikováno v: Molecular Therapy: Oncolytics, Vol 18, Iss , Pp 189-201 (2020)

Targeting metabolic reprogramming is an emerging strategy in cancer therapy. However, clinical attempts to target metabolic reprogramming have been proved to be challenging, with metabolic heterogeneity of cancer being one of many reasons that causes

Externí odkaz: https://doaj.org/article/0c81089cd859412ab2cb4f6d9eda4514

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Akademický článek

The dual PI3K/mTOR inhibitor BEZ235 restricts the growth of lung cancer tumors regardless of EGFR status, as a potent accompanist in combined therapeutic regimens

Autor: Yi-Ying Wu, Hung-Chang Wu, Jia-En Wu, Kuo-Yen Huang, Shuenn-Chen Yang, Si-Xuan Chen, Chao-Jung Tsao, Keng-Fu Hsu, Yuh-Ling Chen, Tse-Ming Hong

Publikováno v: Journal of Experimental & Clinical Cancer Research, Vol 38, Iss 1, Pp 1-16 (2019)

Abstract Background Lung cancer is the most common cause of cancer-related mortality worldwide despite diagnostic improvements and the development of targeted therapies, notably including epidermal growth factor receptor (EGFR) tyrosine kinase inhibi

Externí odkaz: https://doaj.org/article/2e6aa94a9f954f8aa464390326c8d1d3

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Akademický článek

Daxx inhibits hypoxia-induced lung cancer cell metastasis by suppressing the HIF-1α/HDAC1/Slug axis

Autor: Ching-Wen Lin, Lu-Kai Wang, Shu-Ping Wang, Yih-Leong Chang, Yi-Ying Wu, Hsuan-Yu Chen, Tzu-Hung Hsiao, Wei-Yun Lai, Hsuan-Hsuan Lu, Ya-Hsuan Chang, Shuenn-Chen Yang, Ming-Wei Lin, Chi-Yuan Chen, Tse-Ming Hong, Pan-Chyr Yang

Publikováno v: Nature Communications, Vol 7, Iss 1, Pp 1-16 (2016)

Hypoxia and epithelial-to-mesenchymal transition promotes cancer metastasis. Here the authors show that Daxx inhibits hypoxia-induced lung cancer metastasis by attenuating Slug-mediated transcriptional repression of epithelial-like markers that in tu

Externí odkaz: https://doaj.org/article/7aa2a547a6274b01b109ab20da77c6cb

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Akademický článek

Correction: Corrigendum: Daxx inhibits hypoxia-induced lung cancer cell metastasis by suppressing the HIF-1α/HDAC1/Slug axis

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-1 (2017)

Nature Communications 7: Article number: 13867 (2016); Published 22 December 2016; Updated 7 February 2017 The original version of this Article contained an error in the spelling of the author Yih-Leong Chang, which was incorrectly given as Yi-Liang

Externí odkaz: https://doaj.org/article/496761e71c2d49e19fc16ebf7bb8babf

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Akademický článek

Overcoming EGFR T790M-based Tyrosine Kinase Inhibitor Resistance with an Allele-specific DNAzyme

Autor: Wei-Yun Lai, Chi-Yuan Chen, Shuenn-Chen Yang, Jer-Yuarn Wu, Cheng-Ju Chang, Pan-Chyr Yang, Konan Peck

Publikováno v: Molecular Therapy: Nucleic Acids, Vol 3, Iss C (2014)

Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) are the main therapeutic agents used to treat non–small-cell lung cancer patients harboring EGFR-activating mutations. However, most of these patients will eventually develop

Externí odkaz: https://doaj.org/article/85465279870d4b9eb4e41fe38078fd2f

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