Small-Molecule Control of Super-Mendelian Inheritance in Gene Drives

Autor: Víctor López Del Amo, Brittany S. Leger, Kurt J. Cox, Shubhroz Gill, Alena L. Bishop, Garrett D. Scanlon, James A. Walker, Valentino M. Gantz, Amit Choudhary

Publikováno v: Cell Reports, Vol 31, Iss 13, Pp 107841- (2020)

Summary: Synthetic CRISPR-based gene-drive systems have tremendous potential in public health and agriculture, such as for fighting vector-borne diseases or suppressing crop pest populations. These elements can rapidly spread in a population by breac

Externí odkaz: https://doaj.org/article/df15ab12cf9c4df997f1b386eee938d8

Genome-wide association analysis identifies novel loci for chronotype in 100,420 individuals from the UK Biobank

Autor: Jacqueline M. Lane, Irma Vlasac, Simon G. Anderson, Simon D. Kyle, William G. Dixon, David A. Bechtold, Shubhroz Gill, Max A. Little, Annemarie Luik, Andrew Loudon, Richard Emsley, Frank A. J. L. Scheer, Deborah A. Lawlor, Susan Redline, David W. Ray, Martin K. Rutter, Richa Saxena

Publikováno v: Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)

Here, Richa Saxena and colleagues perform a genome-wide association study (GWAS) of self-reported morningness/eveningness preference in the UKBiobank cohort, and identify new genetic loci that contribute to a person's chronotype.

Externí odkaz: https://doaj.org/article/c25bbc1d847e4c298d251095a613c6b1

An expanded universe of cancer targets

Autor: Filemon S. Dela Cruz, Hiroyuki Yoda, Calvin J. Kuo, William C. Hahn, Kelly Kersten, Olivier Gevaert, Michitaka Nakano, Bruce K. Hua, Yohannes Tsehay, Han Liang, Yun Rose Li, Taofeek K. Owonikoko, Yunqi Yan, Katherine N. Liu, Stephen E. Kurtz, Andrew J. Ewald, Gordon B. Mills, Matthew Dunworth, Yuhao Wang, Eloise M. Grasset, Joseph Estabrook, Nicola Long, Vasanthi S. Viswanathan, Bridget Robinson, Shubhroz Gill, Matthew C. Perrone, Ken Chen, Suresh S. Ramalingam, Robert T. Manguso, Asmita Bhattacharya, Andrea Califano, Wei Zhou, Yuhong Du, Elodie Henriet, Jordana Brown, Francisca Vazquez, Michael T. McManus, Manisha Warrier, Gabriel Eades, Anuja Sathe, Yilong Zou, Yoko Kosaka, Matthew A. Reyna, Theodore P. Braun, Daniela S. Gerhard, Matthew F. Krummel, Allan Balmain, Tamilla Nechiporuk, Hanlee P. Ji, Quin Morrow, Emek Demir, Pablo Tamayo, Jessica Minnier, Michael C. Bassik, Kevin Watanabe-Smith, Xiulei Mo, Qi-Wen Fan, Nicole Nasholm, Sagar Lonial, Stuart L. Schreiber, Brent R. Stockwell, Nina K. Serwas, Sourav Bandyopadhyay, Brian J. Druker, Christina Curtis, Yuan-Hung Lo, Olga Nikolova, Qiankun Niu, Veena Padmanaban, Yuchen Ge, Cristina E. Tognon, Anupriya Agarwal, Christopher J. Kemp, Kremena Karagyozova, Haian Fu, Trevor Bivona, Dan Georgess, Nidhi Sahni, Stefan Oberlin, Issac S. Chan, Michael G. Lerner, Matt Hangauer, Jennifer Saultz, Wing Hing Wong, Ilya Shmulevich, Christin Schmidt, Yasir Suhail, Andy Kaempf, Alan Ashworth, Saumya R. Bollam, Tanaz Sharifnia, Jesse S. Boehm, Kasper Karlsson, Carlos S. Moreno, Neil Tay, Michael Grzadkowski, Kevin C. Brennan, Subhashini Jagu, Elizabeth M. Swisher, Ben Deneen, Jessica A. Talamas, Amber R. Smith, Joel S. Bader, Vlado Dančík, Andrew L. Kung, William A. Weiss, Hildur Knutsdottir, Tania Q. Vu, Lee Cooper, Kanako Yuki, Wei-Ching Chen, Bridget K. Wagner, Evan F. Lind, Josh Dempster, Marie Menard, Carla Grandori, Andrey A. Ivanov, William Kim, Jeffrey W. Tyner, Jonathan S. Weissman, Thomas Jacob, Paul A. Clemons, Jitong Cai, Kaitlyn Spees, Dan S. Kaufman

Publikováno v: Cell, vol 184, iss 5
Cell

The characterization of cancer genomes has provided insight into somatically altered genes across tumors, transformed our understanding of cancer biology, and enabled tailoring of therapeutic strategies. However, the function of most cancer alleles r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b9eecba249a534391089dc341a11f66
https://doi.org/10.1016/j.cell.2021.02.020

Genome-wide association analysis identifies novel loci for chronotype in 100,420 individuals from the UK Biobank

Autor: Max A. Little, Richa Saxena, Simon G. Anderson, Andrew S. I. Loudon, Shubhroz Gill, Debbie A Lawlor, Richard Emsley, Martin K. Rutter, Irma Vlasac, David A. Bechtold, Jacqueline M. Lane, David W. Ray, Simon D. Kyle, Susan Redline, Frank A.J.L. Scheer, Annemarie I. Luik, William G Dixon

Publikováno v: Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
Lane, J M, Vlasac, I, Anderson, S G, Kyle, S D, Dixon, W G, Bechtold, D A, Gill, S, Little, M A, Luik, A, Loudon, A, Emsley, R, Scheer, F A J L, Lawlor, D A, Redline, S, Ray, D W, Rutter, M K & Saxena, R 2016, ' Genome-wide association analysis identifies novel loci for chronotype in 100,420 individuals from the UK Biobank ', Nature Communications, vol. 7, 10889 . https://doi.org/10.1038/ncomms10889
Nature Communications

Our sleep timing preference, or chronotype, is a manifestation of our internal biological clock. Variation in chronotype has been linked to sleep disorders, cognitive and physical performance, and chronic disease. Here we perform a genome-wide associ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbb4b4f34044ecb1fd11150e08ac3b71
https://doaj.org/article/c25bbc1d847e4c298d251095a613c6b1

Genome-wide association analyses of sleep disturbance traits identify new loci and highlight shared genetics with neuropsychiatric and metabolic traits

Autor: Xiaofeng Zhu, Shubhroz Gill, Jack Bowden, Frank A.J.L. Scheer, Annemarie I. Luik, Richard Emsley, David A. Bechtold, Jacqueline M. Lane, Shaun Purcell, Irma Vlasac, Martin K. Rutter, Andrew S. I. Loudon, Richa Saxena, Simon G. Anderson, Jingjing Liang, Max A. Little, Debbie A Lawlor, Simon D. Kyle, Susan Redline, David W. Ray

Publikováno v: Lane, J M, Liang, J, Vlasac, I, Anderson, S, Bechtold, D, Bowden, J, Emsley, R, Gill, S, Little, M A, Luik, A, Loudon, A, Scheer, F A J L, Purcell, S, Kyle, S D, Lawlor, D A, Zhu, X, Redline, S, Ray, D, Rutter, M & Saxena, R 2016, ' Genome-wide association analyses of sleep disturbance traits identify new loci and highlight shared genetics with neuropsychiatric and metabolic traits ', Nature Genetics, vol. 49, pp. 274-281 . https://doi.org/10.1038/ng.3749
Lane, J M, Liang, J, Vlasac, I, Anderson, S G, Bechtold, D A, Bowden, J, Emsley, R, Gill, S, Little, M A, Luik, A I, Loudon, A, Scheer, F A J L, Purcell, S M, Kyle, S D, Lawlor, D A, Zhu, X, Redline, S, Ray, D W, Rutter, M K & Saxena, R 2017, ' Genome-wide association analyses of sleep disturbance traits identify new loci and highlight shared genetics with neuropsychiatric and metabolic traits ', Nature Genetics, vol. 49, no. 2, pp. 274-281 . https://doi.org/10.1038/ng.3749
Lane, J, Liang, J, Vlasac, I, Anderson, S G, Bechtold, D A, Bowden, J, Emsley, R, Gill, S, A Little, M, Luik, A I, Loudon, A, Scheer, F A J L, Purcell, S M, Kyle, S D, Lawlor, D, Zhu, X, Redline, S, Ray, D W, Rutter, M K & Saxena, R 2017, ' Genome-wide association analyses of sleep disturbance traits identify new loci and highlight shared genetics with neuropsychiatric and metabolic traits ', Nature Genetics, vol. 49, no. 2, pp. 274–281 . https://doi.org/10.1038/ng.3749

Chronic sleep disturbances, associated with cardio-metabolic diseases, psychiatric disorders and all-cause mortality1,2, affect 25–30% of adults worldwide3. While environmental factors contribute importantly to self-reported habitual sleep duration

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::603363846bc66bb1771befa126d2c257
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