Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Shubhendu Palei"'
Autor:
Shubhendu Palei, Jörn Weisner, Melina Vogt, Rajesh Gontla, Benjamin Buchmuller, Christiane Ehrt, Tobias Grabe, Silke Kleinbölting, Matthias Müller, Guido H. Clever, Daniel Rauh, Daniel Summerer
Ten-eleven translocation dioxygenases (TETs) are the erasers of 5-methylcytosine (mC), the central epigenetic regulator of mammalian DNA. TETs convert mC to three oxidized derivatives with unique physicochemical properties and inherent regulatory pot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39d120b97693d77b10687f4944c2e4be
Autor:
Julian Kanne, Shubhendu Palei, Michal R. Schweiger, Jan Wolffgramm, Petra Janning, Benjamin Buchmuller, Daniel Summerer, Álvaro Muñoz-López
Publikováno v:
Angewandte Chemie (International Ed. in English)
5‐Methylcytosine (5mC), the central epigenetic mark of mammalian DNA, plays fundamental roles in chromatin regulation. 5mC is written onto genomes by DNA methyltransferases (DNMT), and perturbation of this process is an early event in carcinogenesi
Autor:
Henning D. Mootz, Shubhendu Palei
Publikováno v:
Chemical Communications. 57:4194-4197
A dual-intein approach for the preparation of head-to-tail macrocyclic peptides is reported, where synthetic and genetically encoded fragments are ligated by two native peptide bonds. A split intein ligates the synthetic and genetically encoded pepti
Autor:
Benjamin C. Buchmuller, Jessica Dröden, Himanshu Singh, Shubhendu Palei, Malte Drescher, Rasmus Linser, Daniel Summerer
5-Methylcytosine (mC) and 5-hydroxymethylcytosine (hmC), the two main epigenetic modifications of mammalian DNA, exist in symmetric and asymmetric combinations in the two strands of CpG dyads. However, revealing such combinations in single DNA duplex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b583e9f0432281da722bb85e38e7997a
Publikováno v:
Methods in Molecular Biology ISBN: 9781071616888
Semisynthetic cyclic peptides bearing both non-proteinogenic and genetically encoded amino acids are excellent ligands for peptide-based drug discovery. While semisynthesis expands the chemical space, genetic encoding allows access to a large library
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ab07b27743a43233afa51f1524847aaf
https://doi.org/10.1007/978-1-0716-1689-5_11
https://doi.org/10.1007/978-1-0716-1689-5_11
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2371
Semisynthetic cyclic peptides bearing both non-proteinogenic and genetically encoded amino acids are excellent ligands for peptide-based drug discovery. While semisynthesis expands the chemical space, genetic encoding allows access to a large library
Autor:
Shubhendu, Palei, Henning D, Mootz
Publikováno v:
Chemical communications (Cambridge, England). 57(34)
A dual-intein approach for the preparation of head-to-tail macrocyclic peptides is reported, where synthetic and genetically encoded fragments are ligated by two native peptide bonds. A split intein ligates the synthetic and genetically encoded pepti
Autor:
Paul Czodrowski, Benjamin Buchmuller, Sascha Jung, Jan Wolffgramm, Álvaro Muñoz-López, Daniel Summerer, Shubhendu Palei
Publikováno v:
Journal of the American Chemical Society
Ten-eleven-translocation (TET) dioxygenases catalyze the oxidation of 5-methylcytosine (5mC), the central epigenetic regulator of mammalian DNA. This activity dy- namically reshapes epigenome and transcriptome by deposit- ing oxidized 5mC derivatives
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::769f3b8763cf9de5bb62d3579dd88dcd
Autor:
Shubhendu Palei, Henning D. Mootz
Publikováno v:
ChemBioChem. 17:378-382
Cyclic peptides can be highly valuable as bioactive molecules, both for biomedical applications and in basic research. We introduce a new fragment-based approach to access cyclic peptide structures in which one fragment is of synthetic origin and the
Publikováno v:
Chembiochem : a European journal of chemical biology. 20(1)
Semisynthetic cyclic peptides containing both non-proteinogenic building blocks, as the synthetic part, and a genetically encoded sequence amenable to DNA-based randomization hold great potential to expand the chemical space in the quest for novel bi