Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Shubhasis Haldar"'
Autor:
Debojyoti Chowdhury, Ayush Mistry, Debashruti Maity, Riti Bhatia, Shreyansh Priyadarshi, Simran Wadan, Soham Chakraborty, Shubhasis Haldar
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-16 (2024)
Abstract Kindlins serve as mechanosensitive adapters, transducing extracellular mechanical cues to intracellular biochemical signals and thus, their perturbations potentially lead to cancer progressions. Despite the kindlin involvement in tumor devel
Externí odkaz:
https://doaj.org/article/4f547df8398743b9b7ffee5d49b5104d
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-14 (2022)
Chakraborty et al. uses single-molecule magnetic tweezers to investigate the chaperone-modulated talin protein mechanics. The results showed that chaperones are involved in the regulation of talin folding/unfolding under mechanical force with some ch
Externí odkaz:
https://doaj.org/article/3c13462da4ca44a1a43751687a6ac600
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
The pathophysiology of autoimmune disorders is multifactorial, where immune cell migration, adhesion, and lymphocyte activation play crucial roles in its progression. These immune processes are majorly regulated by adhesion molecules at cell–extrac
Externí odkaz:
https://doaj.org/article/3c8bb4b1e7094065bd79da644ef02f57
Autor:
Shubhasis Haldar, Rafael Tapia-Rojo, Edward C. Eckels, Jessica Valle-Orero, Julio M. Fernandez
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-7 (2017)
Proteins fold under mechanical force during co-translational folding at the ribosome. Here, the authors use single molecule magnetic tweezers to study the influence of chaperones on protein folding and show that the ribosomal chaperone trigger factor
Externí odkaz:
https://doaj.org/article/c435eaed6d044a0d845d5ba987b97fa9
Autor:
Edward C. Eckels, Shubhasis Haldar, Rafael Tapia-Rojo, Jaime Andrés Rivas-Pardo, Julio M. Fernández
Publikováno v:
Cell Reports, Vol 27, Iss 6, Pp 1836-1847.e4 (2019)
Summary: The delivery of mechanical power, a crucial component of animal motion, is constrained by the universal compromise between the force and the velocity of its constituent molecular systems. While the mechanisms of force generation have been st
Externí odkaz:
https://doaj.org/article/29d69a552a404682bf00166e52125f7d
Autor:
Shubhasis Haldar, Simantasarani Paul, Nidhi Joshi, Anindya Dasgupta, Krishnananda Chattopadhyay
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e31797 (2012)
Viperin, an antiviral protein, has been shown to contain a CX(3)CX(2)C motif, which is conserved in the radical S-adenosyl-methionine (SAM) enzyme family. A triple mutant which replaces these three cysteines with alanines has been shown to have sever
Externí odkaz:
https://doaj.org/article/2fc1e933accd4621b36c3839bd4a3813
Autor:
Soham Chakraborty, Shubhasis Haldar
Publikováno v:
Trends in Biochemical Sciences.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::075efb37c3ede56d8e6e46bcf1f69c5c
https://doi.org/10.1016/j.tibs.2023.05.002
https://doi.org/10.1016/j.tibs.2023.05.002
Autor:
Debojyoti Chowdhury, Sukhamoy Dhabal, Madhu Bhatt, Debashruti Maity, Soham Chakraborty, Keshav Kant Ahuja, Shreyansh Priyadarshi, Shubhasis Haldar
Methotrexate is a well-known antineoplastic drug used to prevent cancer aggravation. Despite being a targeted therapeutic approach, its administration comes with the risk of cancer recurrence, plausibly through its proven off-target effect on focal a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e12b5b947124c88f084ce38455a2b2e6
https://doi.org/10.1101/2023.04.07.535979
https://doi.org/10.1101/2023.04.07.535979
Publikováno v:
Biomacromolecules. 23:2951-2967
Protein folding under force is an integral source of generating mechanical energy in various cellular processes, ranging from protein translation to degradation. Although chaperones are well known to interact with proteins under mechanical force, how
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09523709fa056d49b31e237489053e40
https://doi.org/10.1021/acs.biomac.2c00451
https://doi.org/10.1021/acs.biomac.2c00451
Polypeptide chains experiences mechanical tension while translocating through cellular tunnel. In this scenario, interaction of tunnel-associated chaperones with the emerging polypeptide occurs under force; however, this force-regulated chaperone beh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1be42cbda07a28bfcd4232a2dd108f6c
https://doi.org/10.1101/2023.03.16.532907
https://doi.org/10.1101/2023.03.16.532907