Výsledky vyhledávání - "Shubhashri Mohire"

Determination of Histamine H3-Receptor Antagonist Conessine in Wistar Rat Plasma by a Rapid and Sensitive RP-UFLC Method: Application to a Pharmacokinetic Study

Autor: Shubhashri Mohire, K. Elango, Mahesh Thondawada, Karthik Yamjala, Vishakantha Murthy, Nilesh Sudhakar Ambhore, Shashank Mulukutla, Rama Satyanarayana Raju Kalidhindi

Publikováno v: Journal of Young Pharmacists. 12:55-62

Objectives: Epidemiological data suggests the highest density of histamine H3-receptors (H3R) in basal ganglia of central nervous system (CNS) wherein they function as inhibitory auto-receptors and control the release of many neurotransmitters. Inhib

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::99ac422528e4bf043dd68ab649faa364
https://doi.org/10.5530/jyp.2020.12.11

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Brain Targeting of 1,9-Pyrazoloanthrone an c-Jun-N-terminal Kinase Inhibitor Using Liposomes for Effective Management of Parkinson's Disease

Autor: Nilesh Sudhakar, Ambhore, Kalidhindi Rama, Satyanarayana Raju, Shashank, Mulukutla, Karthik, Yamjala, Shubhashri, Mohire, Veera Venkata, Satyanarayana Reddy Karri, Saurabh, Gupta, Vishakantha, Murthy, Kannan, Elango

Publikováno v: Iranian Journal of Pharmaceutical Research : IJPR

The major challenge to treat Parkinson’s disease (PD) is penetration of target molecule into the brain to improve the efficacy of drugs. To achieve better brain penetration and targeted delivery, 1,9-Pyrazoloanthrone (1,9-P) loaded liposomes were d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a3e8f1f76e4dc0e6450664182a754432
https://pubmed.ncbi.nlm.nih.gov/29552055

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Pharmacokinetic and tissue distribution studies of 1,9-pyrazoloanthrone, a c-Jun-N-terminal kinase inhibitor in Wistar rats by a simple and sensitive HPLC method

Autor: Shubhashri Mohire, Shashank Mulukutla, Mahesh Tondhawada, Karthik Yamjala, Vishakantha Murthy, Nilesh Sudhakar Ambhore, K. Elango, Kalidhindi Rama Satyanarayana Raju

Publikováno v: Journal of pharmaceutical and biomedical analysis. 120

JNK pathway activates c-Jun(s) which are responsible for cell apoptosis; as a result, inhibitors of JNK pathway have the potential to prevent dopaminergic neurons from death and decrease the loss of dopamine in substantia nigra pars compacta (SNpc).

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58a70a693e06f3a4f56c844312e8987e
https://pubmed.ncbi.nlm.nih.gov/26704630

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H-3 Receptor Antagonist and JNK-3 Inhibitor: A new therapeutic approach to treat Parkinson’s disease

Autor: Shubhashri Mohire, Ramasatyanarayana Raju Kalidindi, Elango Kannan, Shashank Mulukutala, Vishakantha Murthy, Nilesh Sudhakar Ambhore

Publikováno v: Parkinsonism & Related Disorders. 22:e91

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e906e19eecc05a9739117346a8fb6ab5
https://doi.org/10.1016/j.parkreldis.2015.10.193

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