Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Shubhashish M.M. Mukhopadhyay"'
Autor:
Laiyin Nie, S.R. Bushell, Victoria Cole, Paul Brennan, Tiago Moreira, A. Quigley, Gian Filippo Ruda, Leela Shrestha, James D. Love, Tomas C. Pascoa, N.A. Burgess-Brown, Shubhashish M.M. Mukhopadhyay, Elisabeth P. Carpenter, A. Chu, Ashley C. W. Pike, David Speedman
Publikováno v:
Nat Struct Mol Biol
Very long chain fatty acids (VLCFAs) are essential building blocks for the synthesis of ceramides and sphingolipids. The first step in the fatty acid elongation cycle is catalyzed by the 3-keto acyl-coenzyme A (CoA) synthases (in mammals, ELOVL elong
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb0907c639374e2c6daac672f563b845
https://doi.org/10.1038/s41594-021-00605-6
https://doi.org/10.1038/s41594-021-00605-6
Autor:
Shayla Venkaya, Gamma Chi, N.A. Burgess-Brown, Pu Qian, Alejandra Fernández-Cid, Katharina L. Duerr, Kasim Sader, Lucie Delemotte, Manuel Covarrubias, Mazdak Radjainia, Gavin McKinley, Shubhashish M.M. Mukhopadhyay, Pablo Castro-Hartmann, Nanki Kaur Singh, Qiansheng Liang, Akshay Sridhar
Kv3 channels have distinctive gating kinetics tailored for rapid repolarization in fast-spiking neurons. Malfunction of this process due to genetic variants in the KCNC1 gene causes severe epileptic disorders, yet the structural determinants for the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::18daad6687d0b1bf7eba32f0dc453a1a
https://doi.org/10.21203/rs.3.rs-828003/v1
https://doi.org/10.21203/rs.3.rs-828003/v1
Autor:
Paul Brennan, James D. Love, Leela Shrestha, Laiyin Nie, Gian Filippo Ruda, Tomas C. Pascoa, Shubhashish M.M. Mukhopadhyay, A. Chu, A. Quigley, Victoria Cole, Tiago Moreira, S.R. Bushell, Elisabeth P. Carpenter, N.A. Burgess-Brown, Ashley C. W. Pike, David Speedman
Very long chain fatty acids (VLCFAs) are essential building blocks for synthesis of the ceramides and sphingolipids required for nerve, skin and retina function and 3-keto acyl-CoA synthases (ELOVL elongases) perform the first step in the FA elongati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7454b44666c6c5228050e372073713a1
https://doi.org/10.1101/2020.11.11.378570
https://doi.org/10.1101/2020.11.11.378570
Autor:
Henry Man, Nicola A. Burgess-Brown, Shubhashish M.M. Mukhopadhyay, Katherine J. Ellis, Alejandra Fernández-Cid, Pravin Mahajan, Katharina L. Dürr, Gamma Chi
Publikováno v:
Methods in Molecular Biology ISBN: 9781071608913
This chapter describes the step-by-step methods employed by the Structural Genomics Consortium (SGC) for screening and producing proteins in the BacMam system. This eukaryotic expression system was selected and a screening process established in 2016
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1ccb4a2abb72410cca76ff3ab046dfd4
https://doi.org/10.1007/978-1-0716-0892-0_6
https://doi.org/10.1007/978-1-0716-0892-0_6
Autor:
Nicola A. Burgess-Brown, Shubhashish M.M. Mukhopadhyay, Pravin Mahajan, Claire Strain-Damerell, Alejandra Fernández-Cid, Opher Gileadi
Publikováno v:
Methods in Molecular Biology ISBN: 9781071608913
In Chapter 3 , we described the Structural Genomics Consortium (SGC) process for generating multiple constructs of truncated versions of each protein using LIC. In this chapter we provide a step-by-step procedure of our E. coli system for test expres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9c471e229b3efb2f54b4755d904769f0
https://doi.org/10.1007/978-1-0716-0892-0_5
https://doi.org/10.1007/978-1-0716-0892-0_5
Autor:
Leela Shrestha, Heinrich Meier, Stephen J. Tucker, Shubhashish M.M. Mukhopadhyay, Aytug K. Kiper, Elisabeth P. Carpenter, N.A. Burgess-Brown, Susanne Rinné, Ashley C. W. Pike, Michael G. Hahn, Karin E. J. Rödström, Wei Zhang, A. Quigley, Thomas Müller, Matthias Goldstein, Magdalena Platzk, David Speedman, Niels Decher, Martina Delbeck, Linus J. Conrad
TWIK-related acid-sensitive potassium (TASK) channels—members of the two pore domain potassium (K2P) channel family—are found in neurons1, cardiomyocytes2–4 and vascular smooth muscle cells5, where they are involved in the regulation of heart r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::096eaf3bc556c30ff74ca034592deea8
https://ora.ox.ac.uk/objects/uuid:ccfd06d8-38f8-4a7f-826c-b775098feab8
https://ora.ox.ac.uk/objects/uuid:ccfd06d8-38f8-4a7f-826c-b775098feab8
Autor:
Conor McClenaghan, Alexandra Mackenzie, Y.Y. Dong, N.A. Burgess-Brown, A. Quigley, Gian Filippo Ruda, Lishuang Cao, Michael V. Clausen, L. Dong, Prafulla Aryal, S. Goubin, Stephen J. Tucker, Shubhashish M.M. Mukhopadhyay, Mark S.P. Sansom, Elisabeth P. Carpenter, Mariana Grieben, Ashley C. W. Pike, Paul Brennan
A sensitive regulator of cellular potassium A class of potassium channels called K2P channels modulates resting membrane potential in most cells. The channels are regulated by multiple ligands, including the antidepressant drug Prozac, as well as fac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ff00a48d4ce518c6ebb694b50186d46
https://doi.org/10.1126/science.1261512
https://doi.org/10.1126/science.1261512
Autor:
Magdalena Platzk, Matthias Goldstein, Karin E. J. Rödström, Thomas Mueller, N.A. Burgess-Brown, Niels Decher, David Speedman, A. Quigley, Leela Shrestha, Ashley C. W. Pike, Stephen J. Tucker, Aytug K. Kiper, Michael G. Hahn, Wei Zhang, Martina Delbeck, Susanne Rinné, Heinrich Meier, Linus J. Conrad, Elisabeth P. Carpenter, Shubhashish M.M. Mukhopadhyay
TASK channels are unusual members of the two-pore domain potassium (K2P) channel family, with unique and unexplained physiological and pharmacological characteristics. TASKs are found in neurons1,2, cardiomyocytes3–5 and vascular smooth muscle cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17291ea4dc5113dfd63aa4378c450609
https://doi.org/10.1101/706168
https://doi.org/10.1101/706168
Autor:
Hua Wang, N.A. Burgess-Brown, Katsiaryna Belaya, Sylvain F. Royer, Sadra Hamedzade, Andaleeb Sajid, S.R. Bushell, Shahid Mehmood, Ashley C. W. Pike, Takuya Machida, Wei Wei Liu, Carol V. Robinson, David Beeson, Wei-Min Liu, Y.Y. Dong, Mervyn J. Bibb, Benjamin G. Davis, David A. Widdick, Seung Seo Lee, Filip J. Wyszynski, Shubhashish M.M. Mukhopadhyay, Clifton E. Barry, Elisabeth P. Carpenter, Leela Shrestha, Ricardo Lucas, Helena I. Boshoff, Stephen A. Cochrane, A. Chu
SummaryProtein glycosylation is a widespread post-translational modification. The first committed step to the lipid-linked glycan used for this process is catalysed by dolichyl-phosphate N-acetylglucosamine-phosphotransferase DPAGT1 (GPT/E.C. 2.7.8.1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::276ba68a90e798d26899fbe7f2ff3797
Autor:
Shahid Mehmood, Ricardo Lucas, Sadra Hamedzadeh, Helena I. Boshoff, Mervyn J. Bibb, Stephen A. Cochrane, N.A. Burgess-Brown, Hua Wang, A. Chu, S.R. Bushell, David Beeson, Katsiaryna Belaya, Wei Wei Liu, Sylvain F. Royer, Andaleeb Sajid, Ashley C. W. Pike, Elisabeth P. Carpenter, Takuya Machida, Leela Shrestha, David A. Widdick, Benjamin G. Davis, Seung Seo Lee, Clifton E. Barry, Shubhashish M.M. Mukhopadhyay, Filip J. Wyszynski, Y.Y. Dong, Carol V. Robinson, Wei-Min Liu
Publikováno v:
SSRN Electronic Journal.
Protein glycosylation is a widespread post-translational modification. The first committed step to the lipid-linked glycan used for this process is catalysed by dolichyl-phosphate N-acetylglucosamine-phosphotransferase DPAGT1 (GPT/E.C. 2.7.8.15). Mis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::381599891351649a9034cb4c6cc5312b
https://doi.org/10.2139/ssrn.3188395
https://doi.org/10.2139/ssrn.3188395