Zobrazeno 1 - 10
of 378
pro vyhledávání: '"Shubham Pant"'
Autor:
Ramesh Khadayat, Mukesh Bishwakarma, Shubham Pant, Om Prakash Bhatta, Pariwesh Raj Bista, Sher Bahadur Kamar
Publikováno v:
eJHaem, Vol 5, Iss 5, Pp 913-919 (2024)
Abstract Background Sickle cell disease (SCD) is the most common hemoglobinopathy caused by an autosomal recessive genetic disorder leading to increased morbidity and mortality rates. SCD is prevalent in the Tharu community in the lowland (Terai) reg
Externí odkaz:
https://doaj.org/article/87a3bd6b11f846c49cd2c87e000fb281
Autor:
Jian Jenny Chen, Melanie Y. Vincent, Dale Shepard, David Peereboom, Devalingam Mahalingam, James Battiste, Manish R. Patel, Dejan Juric, Patrick Y. Wen, Andrea Bullock, Jennifer Eva Selfridge, Shubham Pant, Joyce Liu, Wendy Li, Susanne Fyfe, Suming Wang, Victor Zota, James Mahoney, Randolph S. Watnick, Michael Cieslewicz, Jing Watnick
Publikováno v:
Communications Medicine, Vol 4, Iss 1, Pp 1-15 (2024)
Abstract Background Preclinical studies have demonstrated that VT1021, a first-in-class therapeutic agent, inhibits tumor growth via stimulation of thrombospondin-1 (TSP-1) and reprograms the tumor microenvironment. We recently reported data from the
Externí odkaz:
https://doaj.org/article/57a3efddeea846a6bc779e0ffb283b62
Autor:
Jibran Ahmed, Bettzy Stephen, Yali Yang, Evan Kwiatkowski, Chinenye Lynette Ejezie, Shubham Pant
Publikováno v:
Journal of Immunotherapy and Precision Oncology, Vol 7, Iss 2, Pp 73-81 (2024)
Introduction: Blocking the colony-stimulating factor 1 (CSF-1) signal on tumor-associated macrophages can lead to an upregulation of checkpoint molecules, such as programmed cell death ligand 1 (PD-L1), thus causing resistance to this blockade. Combi
Externí odkaz:
https://doaj.org/article/0bc48ceaa13a42b6812f3e1cba9082de
Publikováno v:
Journal of Nepal Medical Association, Vol 62, Iss 276 (2024)
Herbicide such as 2,4-Dichlorophenoxyacetic acid is commonly used in wheat growing regions and is being ingested with suicidal intent due to easy availability and lack of regulation for buying it. Various articles suggest high fatality upon ingestion
Externí odkaz:
https://doaj.org/article/96494fb9f79a4873b0026cb795346faf
Autor:
Heather Lin, Vivek Subbiah, Siqing Fu, Aung Naing, Courtney Nicholas, Shubham Pant, Chad Tang, Michael A Curran, David S Hong, Ying Yuan, Sarina A Piha-Paul, Jordi Rodon Ahnert, Timonthy A Yap, Apostolia M Tsimberidou, Daniel D Karp, Anupallavi Srinivasamani, Coline Couillault, Genevieve P Hartley, James Dai, Ecaterina E Ileana Dumbrava, Paola Guerrero, Sarah Dhebat, Theresa Proia
Publikováno v:
BMJ Oncology, Vol 3, Iss 1 (2024)
Objective To evaluate signal transducer and activator of transcription 3 (STAT3) inhibition we conducted a co-clinical trial testing danvatirsen, a STAT3 antisense oligonucleotide (ASO) and checkpoint inhibition in conjunction with preclinical experi
Externí odkaz:
https://doaj.org/article/fd1c2105b438497dab4139b2a44f11d7
Autor:
Abdelrahman Yousef, Mahmoud Yousef, Saikat Chowdhury, Kawther Abdilleh, Mark Knafl, Paul Edelkamp, Kristin Alfaro-Munoz, Ray Chacko, Jennifer Peterson, Brandon G. Smaglo, Robert A. Wolff, Shubham Pant, Michael S. Lee, Jason Willis, Michael Overman, Sudheer Doss, Lynn Matrisian, Mark W. Hurd, Rebecca Snyder, Matthew H. G. Katz, Huamin Wang, Anirban Maitra, John Paul Shen, Dan Zhao
Publikováno v:
npj Precision Oncology, Vol 8, Iss 1, Pp 1-13 (2024)
Abstract The relevance of KRAS mutation alleles to clinical outcome remains inconclusive in pancreatic adenocarcinoma (PDAC). We conducted a retrospective study of 803 patients with PDAC (42% with metastatic disease) at MD Anderson Cancer Center. Ove
Externí odkaz:
https://doaj.org/article/07e4c9e5f98d41abaef00dd9155ae1ad
Autor:
Chantale Bernatchez, Shubham Pant, Rodabe Amaria, Marie-Andree Forget, Milind Javle, Donastas Sakellariou-Thompson, Karen H Lu, Scott Kopetz, Mara B Antonoff, Cara L Haymaker, Ying Yuan, Robert A Wolff, Michael J Overman, Anne Knisely, Amir A Jazaeri, Bryan Fellman, Kelly Rangel, David Vining, Ching-Wei D Tzeng, Kathryn Lito
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 12, Iss 2 (2024)
Background Tumor-infiltrating lymphocyte (TIL) therapy has shown efficacy in metastatic melanoma, non-small cell lung cancer, and other solid tumors. Our preclinical work demonstrated more robust CD8 predominant TIL production when agonistic anti-4-1
Externí odkaz:
https://doaj.org/article/9db26df43372455eb057f56b039dcefa
Autor:
Omar Alhalabi, Roman Groisberg, Ralph Zinner, Andrew W. Hahn, Aung Naing, Shizhen Zhang, Apostolia M. Tsimberidou, Jordi Rodon, Siqing Fu, Timothy A. Yap, David S. Hong, Ming Sun, Yunfang Jiang, Shubham Pant, Amishi Y. Shah, Amado Zurita, Nizar M. Tannir, Raghunandan Vikram, Jason Roszik, Funda Meric-Bernstam, Vivek Subbiah
Publikováno v:
npj Precision Oncology, Vol 7, Iss 1, Pp 1-10 (2023)
Abstract Pre-clinically, the mTORC1/2 inhibitor sapanisertib restored sensitivity to platinums and enhanced paclitaxel-induced cancer cell killing. NCT03430882 enrolled patients with mTOR pathway aberrant tumors to receive sapanisertib, carboplatin a
Externí odkaz:
https://doaj.org/article/0e41dd980da3400cb70f16af34c1c22a
Autor:
Aung Naing, Funda Meric-Bernstam, Shubham Pant, Milind Javle, Juhee Song, Anas Alshawa, Bettzy Stephen, Abdulrazzak Zarifa, Jordi Rodon, Yali Yang, Robert A Wolff, Anne Knisely, Van Morris, Jibran Ahmed
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/4393ea0221804f6abebff45f2608d526
Autor:
Shubham Pant, Cullen Taniguchi, Ethan Ludmir, Vincent Bernard, Sonal Noticewala, Eric Perez Perez, Ching Wei Tzeng
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 2 (2023)
Externí odkaz:
https://doaj.org/article/b437f6b7c984405d89aa91c58b33e76c