Zobrazeno 1 - 10
of 374
pro vyhledávání: '"Shubham Pant"'
Autor:
Jian Jenny Chen, Melanie Y. Vincent, Dale Shepard, David Peereboom, Devalingam Mahalingam, James Battiste, Manish R. Patel, Dejan Juric, Patrick Y. Wen, Andrea Bullock, Jennifer Eva Selfridge, Shubham Pant, Joyce Liu, Wendy Li, Susanne Fyfe, Suming Wang, Victor Zota, James Mahoney, Randolph S. Watnick, Michael Cieslewicz, Jing Watnick
Publikováno v:
Communications Medicine, Vol 4, Iss 1, Pp 1-15 (2024)
Abstract Background Preclinical studies have demonstrated that VT1021, a first-in-class therapeutic agent, inhibits tumor growth via stimulation of thrombospondin-1 (TSP-1) and reprograms the tumor microenvironment. We recently reported data from the
Externí odkaz:
https://doaj.org/article/57a3efddeea846a6bc779e0ffb283b62
Autor:
Jibran Ahmed, Bettzy Stephen, Yali Yang, Evan Kwiatkowski, Chinenye Lynette Ejezie, Shubham Pant
Publikováno v:
Journal of Immunotherapy and Precision Oncology, Vol 7, Iss 2, Pp 73-81 (2024)
Introduction: Blocking the colony-stimulating factor 1 (CSF-1) signal on tumor-associated macrophages can lead to an upregulation of checkpoint molecules, such as programmed cell death ligand 1 (PD-L1), thus causing resistance to this blockade. Combi
Externí odkaz:
https://doaj.org/article/0bc48ceaa13a42b6812f3e1cba9082de
Autor:
Abdelrahman Yousef, Mahmoud Yousef, Saikat Chowdhury, Kawther Abdilleh, Mark Knafl, Paul Edelkamp, Kristin Alfaro-Munoz, Ray Chacko, Jennifer Peterson, Brandon G. Smaglo, Robert A. Wolff, Shubham Pant, Michael S. Lee, Jason Willis, Michael Overman, Sudheer Doss, Lynn Matrisian, Mark W. Hurd, Rebecca Snyder, Matthew H. G. Katz, Huamin Wang, Anirban Maitra, John Paul Shen, Dan Zhao
Publikováno v:
npj Precision Oncology, Vol 8, Iss 1, Pp 1-13 (2024)
Abstract The relevance of KRAS mutation alleles to clinical outcome remains inconclusive in pancreatic adenocarcinoma (PDAC). We conducted a retrospective study of 803 patients with PDAC (42% with metastatic disease) at MD Anderson Cancer Center. Ove
Externí odkaz:
https://doaj.org/article/07e4c9e5f98d41abaef00dd9155ae1ad
Autor:
Chantale Bernatchez, Shubham Pant, Rodabe Amaria, Marie-Andree Forget, Milind Javle, Donastas Sakellariou-Thompson, Karen H Lu, Scott Kopetz, Mara B Antonoff, Cara L Haymaker, Ying Yuan, Robert A Wolff, Michael J Overman, Anne Knisely, Amir A Jazaeri, Bryan Fellman, Kelly Rangel, David Vining, Ching-Wei D Tzeng, Kathryn Lito
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 12, Iss 2 (2024)
Background Tumor-infiltrating lymphocyte (TIL) therapy has shown efficacy in metastatic melanoma, non-small cell lung cancer, and other solid tumors. Our preclinical work demonstrated more robust CD8 predominant TIL production when agonistic anti-4-1
Externí odkaz:
https://doaj.org/article/9db26df43372455eb057f56b039dcefa
Autor:
Aung Naing, Funda Meric-Bernstam, Shubham Pant, Milind Javle, Juhee Song, Anas Alshawa, Bettzy Stephen, Abdulrazzak Zarifa, Jordi Rodon, Yali Yang, Robert A Wolff, Anne Knisely, Van Morris, Jibran Ahmed
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/4393ea0221804f6abebff45f2608d526
Autor:
Shubham Pant, Cullen Taniguchi, Ethan Ludmir, Vincent Bernard, Sonal Noticewala, Eric Perez Perez, Ching Wei Tzeng
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 2 (2023)
Externí odkaz:
https://doaj.org/article/b437f6b7c984405d89aa91c58b33e76c
Autor:
Shubham Pant, Rahul Sheth, Michael S Lee, Jason Laporte, Steven Katz, Joshua D Kuban, Ethan Ludmir, Charla McMichael, Lindsay Laudal, Ann-Marie Hulstine
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/8ef94102aec24529b45c654adb1bd41c
Autor:
Omar Alhalabi, Roman Groisberg, Ralph Zinner, Andrew W. Hahn, Aung Naing, Shizhen Zhang, Apostolia M. Tsimberidou, Jordi Rodon, Siqing Fu, Timothy A. Yap, David S. Hong, Ming Sun, Yunfang Jiang, Shubham Pant, Amishi Y. Shah, Amado Zurita, Nizar M. Tannir, Raghunandan Vikram, Jason Roszik, Funda Meric-Bernstam, Vivek Subbiah
Publikováno v:
npj Precision Oncology, Vol 7, Iss 1, Pp 1-10 (2023)
Abstract Pre-clinically, the mTORC1/2 inhibitor sapanisertib restored sensitivity to platinums and enhanced paclitaxel-induced cancer cell killing. NCT03430882 enrolled patients with mTOR pathway aberrant tumors to receive sapanisertib, carboplatin a
Externí odkaz:
https://doaj.org/article/0e41dd980da3400cb70f16af34c1c22a
Autor:
Ji Son, Heather Y. Lin, Siqing Fu, Amadeo B. Biter, Ecaterina E. Dumbrava, Daniel D. Karp, Aung Naing, Shubham Pant, Sarina A. Piha-Paul, Jordi Rodon, Vivek Subbiah, Apostolia M. Tsimberidou, Timothy A. Yap, Michael M. Frumovitz, Amir A. Jazaeri, Pedro T. Ramirez, Shannon N. Westin, Ying Yuan, Funda Meric-Bernstam, David S. Hong
Publikováno v:
Journal of Immunotherapy and Precision Oncology, Pp 10-18 (2023)
Introduction: We aimed to identify clinical, pathologic, and treatment factors that are predictive of response and survival in patients with cervical cancer referred to phase I clinical trials. Methods: Patients with cervical cancer who received at l
Externí odkaz:
https://doaj.org/article/3292889d49654332a67abe4adc682ab7
Autor:
Stephen L. Chan, Martin Schuler, Yoon-Koo Kang, Chia-Jui Yen, Julien Edeline, Su Pin Choo, Chia-Chi Lin, Takuji Okusaka, Karl-Heinz Weiss, Teresa Macarulla, Stéphane Cattan, Jean-Frederic Blanc, Kyung-Hun Lee, Michela Maur, Shubham Pant, Masatoshi Kudo, Eric Assenat, Andrew X. Zhu, Thomas Yau, Ho Yeong Lim, Jordi Bruix, Andreas Geier, Carmen Guillén-Ponce, Angelica Fasolo, Richard S. Finn, Jia Fan, Arndt Vogel, Shukui Qin, Markus Riester, Vasiliki Katsanou, Monica Chaudhari, Tomoyuki Kakizume, Yi Gu, Diana Graus Porta, Andrea Myers, Jean-Pierre Delord
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 41, Iss 1, Pp 1-19 (2022)
Abstract Background Deregulation of FGF19-FGFR4 signaling is found in several cancers, including hepatocellular carcinoma (HCC), nominating it for therapeutic targeting. FGF401 is a potent, selective FGFR4 inhibitor with antitumor activity in preclin
Externí odkaz:
https://doaj.org/article/1a80d93b46254b83bfdf5d4c0de1a368