Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Shubhadeep Purkayastha"'
Autor:
Cynthia L. Hendrickson, Shubhadeep Purkayastha, Elzbieta Pastwa, Ronald D. Neumann, Thomas A. Winters
Publikováno v:
Journal of Nucleic Acids, Vol 2010 (2010)
In mammalian cells, DNA double-strand breaks (DSBs) are primarily repaired by nonhomologous end joining (NHEJ). The current model suggests that the Ku 70/80 heterodimer binds to DSB ends and recruits DNA-PKcs to form the active DNA-dependent protein
Externí odkaz:
https://doaj.org/article/00cd3c3a0d2843b5a14bc311c2416c41
Publikováno v:
Dose-Response, Vol 6 (2008)
Working under the assumption that hormesis is triggered by specific types of DNA damage, this report focuses on the types of damage which form the signature of ionizing radiation. The key attribute of the signature is the clustering of damage, arisin
Externí odkaz:
https://doaj.org/article/74c3fd72e9904a97835e04bfdab47bd6
Autor:
Cynthia L. Hendrickson, Elzbieta Pastwa, Ronald D. Neumann, Shubhadeep Purkayastha, Thomas A. Winters
Publikováno v:
Journal of Nucleic Acids, Vol 2010 (2010)
Journal of Nucleic Acids
Journal of Nucleic Acids
In mammalian cells, DNA double-strand breaks (DSBs) are primarily repaired by nonhomologous end joining (NHEJ). The current model suggests that the Ku 70/80 heterodimer binds to DSB ends and recruits DNA-PKcsto form the active DNA-dependent protein k
Publikováno v:
The Journal of Physical Chemistry B. 108:18377-18382
The present study tests the hypothesis that the majority of DNA strand breaks produced by direct-type effects are due to sugar free radical precursors and that these radicals are produced by direct ionization of the sugar-phosphate backbone or by hol
Publikováno v:
Methods in Molecular Biology ISBN: 9781617799976
DNA double-strand breaks (DSBs) are caused by endogenous cellular processes such as oxidative metabolism, or by exogenous events like exposure to ionizing radiation or other genotoxic agents. Repair of these DSBs is essential for the maintenance of c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2d4db875a3d0bb0b363ac1f51ff89e5
https://europepmc.org/articles/PMC3506396/
https://europepmc.org/articles/PMC3506396/
Publikováno v:
Radiation research. 175(1)
Radiation-induced DNA double-strand breaks (DSBs) are critical cytotoxic lesions that are typically repaired by nonhomologous end joining (NHEJ) in human cells. Our previous work indicated that the highly cytotoxic DSBs formed by (125)I decay possess
The distance of hole migration through DNA determines the degree to which radiation-induced lesions are clustered. It is the degree of clustering that confers to ionizing radiation its high toxicity. The migration distance is governed by a competitio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b7d71c192cd5ebff175cac569e66b5a
https://europepmc.org/articles/PMC2882639/
https://europepmc.org/articles/PMC2882639/
Autor:
David C. Gilbert, Yuriy Razskazovskiy, Kiran Kumar K. Sharma, Katerina A. Naumenko, William A. Bernhard, Shubhadeep Purkayastha, Steven Swarts
Publikováno v:
Radiation research. 168(3)
Dose-response curves were measured for the formation of direct-type DNA products in X-irradiated d(GCACGCGTGC)(2)prepared as dry films and as crystalline powders. Damage to deoxyribose (dRib) was assessed by HPLC measurements of strand break products
Publikováno v:
Radiation research. 168(3)
The purpose of this study was to determine the yield of DNA base damages, deoxyribose damage, and clustered lesions due to the direct effects of ionizing radiation and to compare these with the yield of DNA trapped radicals measured previously in the
The mechanisms by which ionizing radiation directly causes strand breaks in DNA were investigated by comparing the chemical yield of DNA-trapped free radicals to the chemical yield of DNA single strand break (ssb) and double strand break (dsb), as a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::065f4f8a0c3da6eaae38928cb7c2d70f
https://europepmc.org/articles/PMC1817901/
https://europepmc.org/articles/PMC1817901/