ELEVATE – evaluating Temozolomide and Nivolumab in patients with advanced unresectable previously treated oesophagogastric adenocarcinoma with MGMT methylation: study protocol for a single arm phase II trial

Autor: Elizabeth Smyth, Kelly Cozens, Daniel Griffiths, Kathryn L. Clark, Sean Ewings, Russell Petty, Tim Underwood, Rebecca C. Fitzgerald, James Tanner, Olivier Giger, Shubha Anand, Gareth Griffiths

Publikováno v: BMC Cancer, Vol 22, Iss 1, Pp 1-13 (2022)

Abstract Background For patients with oesophagogastric adenocarcinoma, surgery is the only curative option and despite the use of multimodality therapy, which combines it with chemotherapy and/or radiotherapy, more than 50% of patients will relapse a

Externí odkaz: https://doaj.org/article/1fbe26fc1abc48ce98b26d076e0a6aee

HOXA9 forms a repressive complex with nuclear matrix-associated protein SAFB to maintain acute myeloid leukemia

Autor: Shuchi Agrawal-Singh, Jaana Bagri, George Giotopoulos, Dhoyazan M. A. Azazi, Sarah J. Horton, Cecile K. Lopez, Shubha Anand, Anne-Sophie Bach, Frances Stedham, Robin Antrobus, Jack W. Houghton, George S. Vassiliou, Daniel Sasca, Haiyang Yun, Anthony D. Whetton, Brian J. P. Huntly

HOXA9 is commonly upregulated in acute myeloid leukemia (AML), in which it confers a poor prognosis. Characterizing the protein interactome of endogenous HOXA9 in human AML, we identified a chromatin complex of HOXA9 with the nuclear matrix attachmen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c3adbe43d1d79de2094f6b253d19fc9

Clonal hematopoiesis is not significantly associated with COVID-19 disease severity

Autor: Yifan Zhou, Ruba Shalhoub, Stephanie N. Rogers, Shiqin Yu, Muxin Gu, Margarete A. Fabre, Pedro M. Quiros, Tae-Hoon Shin, Arch Diangson, Wenhan Deng, Shubha Anand, Wenhua Lu, Matthew Cullen, Anna L. Godfrey, Jacobus Preller, Jerome Hadjadj, Emmanuelle Jouanguy, Aurélie Cobat, Laurent Abel, Frederic Rieux-Laucat, Benjamin Terrier, Alain Fischer, Lara Novik, Ingelise J. Gordon, Larisa Strom, Martin R. Gaudinski, Andrea Lisco, Irini Sereti, Thomas J. Gniadek, Andrea Biondi, Paolo Bonfanti, Luisa Imberti, Clifton L. Dalgard, Yu Zhang, Kerry Dobbs, Helen C. Su, Luigi D. Notarangelo, Colin O. Wu, Peter J.M. Openshaw, Malcolm G. Semple, Ziad Mallat, Kenneth Baillie, Cynthia E. Dunbar, George S. Vassiliou

Publikováno v: Zhou, Y, Shalhoub, R N, Rogers, S N, Yu, S, Gu, M, Fabre, M A, Quiros, P M, Diangson, A, Deng, W, Anand, S, Lu, W, Cullen, M, Godfrey, A L, Preller, J, Hadjadj, J, Jouanguy, E, Cobat, A, Abel, L, Rieux-Laucat, F, Terrier, B, Fischer, A, Novik, L, Gordon, I J, Strom, L, Gaudinski, M, Lisco, A, Sereti, I, Gniadek, T J, Biondi, A, Bonfanti, P, Imberti, L, Zhang, Y, Dalgard, C L, Dobbs, K, Su, H C, Notarangelo, L D, Wu, C O, Openshaw, P J M, Semple, M G, Mallat, Z, Baillie, K, Dunbar, C E & Vassiliou, G S 2022, ' Clonal Hematopoiesis Is Not Significantly Associated with Covid-19 Disease Severity ', Blood, vol. 140, no. 14, pp. 1650-1655 . https://doi.org/10.1182/blood.2022015721

Clonal hematopoiesis (CH) describes the disproportionate expansion of a hematopoietic stemcell (HSC) and its progeny, in association with leukemia-associated somatic mutations, mostcommonly affecting the genes for epigenetic regulators DNMT3A, TET2 a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46b76ab2376652b898353a85bd024178
https://www.repository.cam.ac.uk/handle/1810/340199

Effects of the JAK2 mutation on the hematopoietic stem and progenitor compartment in human myeloproliferative neoplasms

Autor: Wendy N. Erber, Anthony R. Green, Emma Gudgin, Brian J. P. Huntly, Shubha Anand, Philip A. Beer, Anthony J. Bench, Frances Stedham, Christina A. Ortmann

Publikováno v: Blood. 118:177-181

The JAK2 V617F mutation is present in the majority of patients with a myeloproliferative neoplasm (MPN) and is sufficient to recapitulate an MPN in murine models. However, the consequences of JAK2 mutations for myeloid differentiation are poorly unde

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d57e414682d952ce99a799f1fcb48b88
https://doi.org/10.1182/blood-2010-12-327593

Insights into DNA recombination from the structure of a RAD51–BRCA2 complex

Autor: Miyoung Lee, Thomas Lo, Ashok R. Venkitaraman, Shubha Anand, Luca Pellegrini, Tom L. Blundell, David S. Yu

Publikováno v: Nature. 420:287-293

The breast cancer susceptibility protein BRCA2 controls the function of RAD51, a recombinase enzyme, in pathways for DNA repair by homologous recombination. We report here the structure of a complex between an evolutionarily conserved sequence in BRC

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2559e1eb2d49867d107f2623e0870c6b
https://doi.org/10.1038/nature01230