Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Shubeena Chib"'
Autor:
Samuel G. Mackintosh, Shubeena Chib, John C. Marecki, Zachary J Waldrip, Andrea D Edwards, Andrea Putnam, Alicia K. Byrd, Michael J. Guderyon, Kevin D. Raney, Boris Zybailov, Zhaofeng Gao, Kirk West, Jun Gao, Eckhard Jankowsky
Publikováno v:
Chemical Communications. 55:4467-4470
We identified 29 G-quadruplex binding proteins by affinity purification and quantitative LC-MS/MS. We demonstrated that the DEAD-box RNA helicases Dbp2, Ded1 and Mss116 preferentially bind to G-quadruplex nucleic acids in vitro and destabilize RNA qu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b96bfaf1d76c9b1c04d1738166b6acd5
https://doi.org/10.1039/c8cc10091h
https://doi.org/10.1039/c8cc10091h
Publikováno v:
Journal of Biological Chemistry. 292:9567-9582
DNA sequences that are guanine-rich have received considerable attention because of their potential to fold into a secondary, four-stranded DNA structure termed G-quadruplex (G4), which has been implicated in genomic instability and some human diseas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00e9d65c7a349dc5cf154d5042d61888
https://doi.org/10.1074/jbc.m117.776211
https://doi.org/10.1074/jbc.m117.776211
Autor:
Mihir Jaiswal, Samuel G. Mackintosh, Shubeena Chib, Wezley C. Griffin, Megan R. Reed, Matthew R. Bell, Boris Zybailov, Kevin D. Raney, Leena Maddukuri, Angus M. MacNicol, Giulia Baldini, John C. Marecki, Alicia K. Byrd, Robert L. Eoff, Jun Gao
Publikováno v:
Journal of Biological Chemistry. 291:18041-18057
Cells engage numerous signaling pathways in response to oxidative stress that together repair macromolecular damage or direct the cell toward apoptosis. As a result of DNA damage, mitochondrial DNA or nuclear DNA has been shown to enter the cytoplasm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c51552b02d2edd479c007967ff206c7a
https://doi.org/10.1074/jbc.m116.718478
https://doi.org/10.1074/jbc.m116.718478
Publikováno v:
Journal of Biological Chemistry. 291:5889-5901
Saccharomyces cerevisiae Pif1, an SF1B helicase, has been implicated in both mitochondrial and nuclear functions. Here we have characterized the preference of Pif1 for RNA:DNA heteroduplexes in vitro by investigating several kinetic parameters associ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a90e542dc6a42a5c7b35a9f4e561a86
https://doi.org/10.1074/jbc.m115.688648
https://doi.org/10.1074/jbc.m115.688648
Autor:
Nayun Kim, Christopher R. Lopez, Shashank Hambarde, Kevin D. Raney, Jun Gao, Wezley C. Griffin, Yang Yu, Shubeena Chib, Grzegorz Ira, Shivani Singh
Publikováno v:
Nucleic Acids Research
G-quadruplex or G4 DNA is a non-B secondary DNA structure consisting of a stacked array of guanine-quartets that can disrupt critical cellular functions such as replication and transcription. When sequences that can adopt Non-B structures including G
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::798db52701ea00230f4ea9786de623d5
https://pubmed.ncbi.nlm.nih.gov/28369605
https://pubmed.ncbi.nlm.nih.gov/28369605
Publikováno v:
Biophysical Journal. 114:394a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b245ac5dd0a704956f3521d08bdeba43
https://doi.org/10.1016/j.bpj.2017.11.2182
https://doi.org/10.1016/j.bpj.2017.11.2182
Autor:
Jun Gao, Samuel G. Mackintosh, Shubeena Chib, Alan J. Tackett, Wezley C. Griffin, Kevin D. Raney, Alicia K. Byrd, Boris Zybailov
Using a G-quadruplex bait, we identified the transcription co-activator Sub1 as a G-quadruplex binding protein by quantitative LC-MS/MS and demonstrated in vivo G-quadruplex binding by ChIP. In vitro, Sub1, and its human homolog PC4, bind preferentia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e686310e14fcd0fbcfde160ab53f77a
https://europepmc.org/articles/PMC4465349/
https://europepmc.org/articles/PMC4465349/
Autor:
Smita S. Patel, Alicia K. Byrd, Manjula Pandey, Suja Aarattuthodiyil, Shubeena Chib, Kevin D. Raney, Ramanagouda Ramanagoudr-Bhojappa
Publikováno v:
The Journal of biological chemistry. 288(22)
Kinetic analysis of the DNA unwinding and translocation activities of helicases is necessary for characterization of the biochemical mechanism(s) for this class of enzymes. Saccharomyces cerevisiae Pif1 helicase was characterized using presteady stat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70621256b24722dab353bca833682dfd
https://pubmed.ncbi.nlm.nih.gov/23596008
https://pubmed.ncbi.nlm.nih.gov/23596008