Výsledky vyhledávání - "Shubana Kazi"

Akademický článek

Proton-assisted amino acid transporter PAT1 complexes with Rag GTPases and activates TORC1 on late endosomal and lysosomal membranes.

Autor: Margrét H Ögmundsdóttir, Sabine Heublein, Shubana Kazi, Bruno Reynolds, Shivanthy M Visvalingam, Michael K Shaw, Deborah C I Goberdhan

Publikováno v: PLoS ONE, Vol 7, Iss 5, p e36616 (2012)

Mammalian Target of Rapamycin Complex 1 (mTORC1) is activated by growth factor-regulated phosphoinositide 3-kinase (PI3K)/Akt/Rheb signalling and extracellular amino acids (AAs) to promote growth and proliferation. These AAs induce translocation of m

Externí odkaz: https://doaj.org/article/3d42d20cec844ce5b8a2fe5ec9edfe50

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PAT4 levels control amino-acid sensitivity of rapamycin-resistant mTORC1 from the Golgi and affect clinical outcome in colorectal cancer

Autor: S-J Fan, S Heublein, R McCormick, Shubana Kazi, Deborah C.I. Goberdhan, Clive Wilson, Adrian L. Harris, Sumeth M.W. Perera, Cameron Snell, A Azad, Helen Turley, J-L Li

Publikováno v: Oncogene

Tumour cells can use strategies that make them resistant to nutrient deprivation to outcompete their neighbours. A key integrator of the cell’s responses to starvation and other stresses is amino-acid-dependent mechanistic target of rapamycin compl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::877d8a94d019919ff64c70fe3321faa4
https://doi.org/10.1038/onc.2015.363

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Amino acid sensing and mTOR regulation: inside or out?

Autor: Margret H. Ogmundsdottir, Bruno Reynolds, Deborah C.I. Goberdhan, C. A. Richard Boyd, Shubana Kazi, Clive Wilson, Shivanthy M. Visvalingam

mTOR (mammalian target of rapamycin) plays a key role in determining how growth factor, nutrient and oxygen levels modulate intracellular events critical for the viability and growth of the cell. This is reflected in the impact of aberrant mTOR signa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad8090cfdb3d024b53777d7a286bf260
https://doi.org/10.1042/bst0370248

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Proton-assisted amino-acid transporters are conserved regulators of proliferation and amino-acid-dependent mTORC1 activation

Autor: E V Attwood, Clive Wilson, Shubana Kazi, C. A. R. Boyd, Margret H. Ogmundsdottir, S Heublein, Deborah C.I. Goberdhan, Snigdha Kala

The phosphoinositide3-kinase (PI3K)/Akt and downstream mammalian target of rapamycin complex 1 (mTORC1) signalling cascades promote normal growth and are frequently hyperactivated in tumour cells. mTORC1 is also regulated by local nutrients, particul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f0f0464b75ffa37dc5aa1f40ee44d15
https://ora.ox.ac.uk/objects/uuid:ea3b62a0-5d3b-43bb-9327-3e3ec79bb224

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Drosophila expresses a CD98 transporter with an evolutionarily conserved structure and amino acid-transport properties

Autor: C. A. Richard Boyd, Bruno Reynolds, Deborah C.I. Goberdhan, Robert Laynes, Shubana Kazi, Pietro Roversi

Publikováno v: Biochemical Journal. 420:363-372

Mammalian CD98 heterodimeric amino acid transporters consist of a promiscuous single-pass transmembrane glycoprotein, CD98hc (CD98 heavy chain), and one of six multipass transmembrane proteins or ‘light chains’. The heterodimeric complexes of CD9

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1049732e6a5093e1ca0d47eec19a258
https://doi.org/10.1042/bj20082198

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Proton-assisted amino acid transporter PAT1 complexes with Rag GTPases and activates TORC1 on late endosomal and lysosomal membranes

Autor: Bruno Reynolds, Deborah C.I. Goberdhan, Sabine Heublein, Michael K. Shaw, Margret H. Ogmundsdottir, Shubana Kazi, Shivanthy M. Visvalingam

Publikováno v: PLoS ONE, Vol 7, Iss 5, p e36616 (2012)
PLoS ONE

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edac6ce1e84e7d79a29093882134c938
http://europepmc.org/articles/PMC3344915?pdf=render

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SLC24A5 encodes a trans-Golgi network protein with potassium-dependent sodium-calcium exchange activity that regulates human epidermal melanogenesis

Autor: Sarah E. Askew, Dudley Ferdinando, Paul P. M. Schnetkamp, Robert J. Winkfein, Robert T. Szerencsei, Stephen Wilson, Rebecca S. Ginger, Martin R. Green, Tony Dadd, Adrian M. Smith, Richard M. Ogborne, Shubana Kazi

Publikováno v: The Journal of biological chemistry. 283(9)

A non-synonymous single nucleotide polymorphism in the human SLC24A5 gene is associated with natural human skin color variation. Multiple sequence alignments predict that this gene encodes a member of the potassium-dependent sodium-calcium exchanger

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dde903e7dd56c4e7fb7850f61c51c8d5
https://pubmed.ncbi.nlm.nih.gov/18166528

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Detoxication of the environmental pollutant acrolein by a rat liver aldo-keto reductase

Autor: Elizabeth M. Ellis, Shubana Kazi, Rachel Gardner

Publikováno v: Toxicology letters. 148(1-2)

Acrolein is a highly reactive hazardous air pollutant of human health concern, particularly as it is a component of cigarette smoke. It can be metabolized by enzymes including the aldo-keto reductase (AKR) family of enzymes. AKR7A1 is a member of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f7b929b0ec04138dab2bb2872b768b8
https://pubmed.ncbi.nlm.nih.gov/15019089

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