Zobrazeno 1 - 10
of 211
pro vyhledávání: '"Shuanhu Gao"'
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-9 (2024)
Abstract The chemoselectivity of organic reactions is a fundamental topic in organic chemistry. In the long history of chemical synthesis, achieving chemoselectivity is mainly limited to thermodynamic conditions by an exogenous activation strategy. H
Externí odkaz:
https://doaj.org/article/3601a9f3b4d94e568e07e06fbb20a341
Autor:
Peipei Shan, Tao Ye, Ying-De Tang, Hui Song, Chao Wang, Kongkai Zhu, Feifei Yang, Shi-Lei Zhang, Pei-Wen Su, Shuanhu Gao, Hua Zhang
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 14, Iss 5, Pp 2177-2193 (2024)
Mornaphthoate E (MPE) is a prenylated naphthoic acid methyl ester isolated from the roots of a famous Chinese medicinal plant Morinda officinalis and shows remarkable cytotoxicity against several human tumor cell lines. In the current project, the fi
Externí odkaz:
https://doaj.org/article/756d1a49160f44f6835196b9c5c560cc
Publikováno v:
Synlett. 2015, Vol. 26 Issue 11, pA92-A94. 3p.
Publikováno v:
Synthesis. 2015, Vol. 47 Issue 13, pA92-A94. 3p.
Autor:
Jie Chen, Nan Liu, Yinpin Huang, Yuanxun Wang, Yuxing Sun, Qingcui Wu, Dianrong Li, Shuanhu Gao, Hong-Wei Wang, Niu Huang, Xiangbing Qi, Xiaodong Wang
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Anagrelide, nauclefine and DNMDP induce apoptosis by forming complexes with phosphodiesterase 3A (PDE3A) and Schlafen 12 protein (SLFN12). Here, the authors present the cryo-EM structures of PDE3A-SLFN12 complexes with these compounds as molecular gl
Externí odkaz:
https://doaj.org/article/37776398a1234184b45de8405e649b5d
Autor:
Youwei Ai, Haibing He, Peihao Chen, Bo Yan, Wenbin Zhang, Zhangcheng Ding, Dianrong Li, Jie Chen, Yan Ma, Yang Cao, Jie Zhu, Jiaojiao Li, Jinjie Ou, Shan Du, Xiaodong Wang, Jianzhang Ma, Shuanhu Gao, Xiangbing Qi
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
PDE3A modulators for cancer therapy cause serious side effects as they inhibit PDE3A phosphodiesterase activity, which is essential for the maturation of oocytes and the formation of platelets. Here, the authors identify a compound, nauclefine, that
Externí odkaz:
https://doaj.org/article/27c89d5e7ff7496cb22ff33c146a9636
Publikováno v:
Organic Chemistry Frontiers. 10:651-660
Zoanthamine alkaloids are structurally unique and complex natural products from marine zoanthids that exhibit a broad range of biological activities and have potential in drug discovery.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::00d427a8f9d41618b796495d7ee7c2e9
https://doi.org/10.1039/d2qo01834a
https://doi.org/10.1039/d2qo01834a
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
Anthracenols with multiple chiral centres are common motifs in natural products. Here, the authors show a highly stereoselective photoenolization/Diels–Alder methodology involving a key Lewis acid reagent enabling the efficient construction of a fa
Externí odkaz:
https://doaj.org/article/0af9120aeae34641b0bef29b9a8df013
Publikováno v:
Chemical Communications. 58:4239-4242
We report herein a concise total synthesis of streptovertidione, and its transformation to streptovertidine A and formicapyridine A through a bioinspired pyridination. This strategy features: (1) a one-pot Ti(O
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0e6586013cee75fe171d18acc4267c1
https://doi.org/10.1039/d2cc00947a
https://doi.org/10.1039/d2cc00947a
Publikováno v:
Angewandte Chemie International Edition. 62
We report herein the asymmetric total synthesis of periglaucines A-C, N,O-dimethyloxostephine and oxostephabenine. The key strategies used include: 1) a Rh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b80fdcc0a9d11b77efe72ee112e8138
https://doi.org/10.1002/anie.202214873
https://doi.org/10.1002/anie.202214873