Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Shuangzhou Peng"'
Autor:
Xiaohui Chen, Meichun Gao, Yongzhen Xia, Xin Wang, Jingbo Qin, Hongying He, Weirong Liu, Xiaowei Zhang, Shuangzhou Peng, Zhiping Zeng, Ying Su, Xiaokun Zhang
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 14, Iss 3, Pp 1204-1221 (2024)
The orphan nuclear receptor Nur77 is a critical regulator of the survival and death of tumor cells. The pro-death effect of Nur77 can be regulated by its interaction with Bcl-2, resulting in conversion of Bcl-2 from a survival to killer. As Bcl-2 is
Externí odkaz:
https://doaj.org/article/9099f275d897481e906a2e2142a26210
Autor:
Yanyan Xu, Dan Chen, Peiwen Liu, Yinping Hu, Shuangzhou Peng, Shanli Chen, Yongkun Li, Wei Lin, Longguang Jiang, Cai Yuan, Mingdong Huang
Publikováno v:
International Journal of Pharmaceutics. 637:122878
Autor:
Chuan-ying Wang, Jie Zhang, Ying Su, Duo Zhang, Shuangzhou Peng, Xiaohui Chen, Si-jie Chen, Xiao-kun Zhang, Wei-rong Liu
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Liquid-liquid phase separation promotes the formation of membraneless condensates that mediate diverse cellular functions, including autophagy of misfolded proteins. However, how phase separation participates in autophagy of dysfunctional mitochondri
Publikováno v:
Thrombosis and Haemostasis. 119:077-086
Recombinant tissue-type plasminogen activator (r-tPA) was approved by U.S. Food and Drug Administration as a thrombolytic drug. However, a high dose of r-tPA (up to 100 mg/person) is typically used in clinical applications. Such high dosage leads to
Autor:
Yanyan, Xu, Shanli, Chen, Dan, Chen, Shuangzhou, Peng, Yuan, Cheng, Jinyu, Li, Yongkun, Li, Longguang, Jiang, Cai, Yuan, Mingdong, Huang
Publikováno v:
Sheng wu gong cheng xue bao = Chinese journal of biotechnology. 36(10)
Ischemic stroke is a major health crisis causing high mortality and morbidity. The key treatment relies on the rapid intervention to dissolve thrombus, to reduce bleeding side effect and re-canalize clotted blood vessels using clot lysis drugs. Tissu
Autor:
Mingdong Huang, Zhuo Chen, Chao Fang, Jingfei Chen, Bruce Furie, Lihu Gong, Cai Yuan, Lishan Yao, Shuangzhou Peng, Guangpu Xue
Publikováno v:
Thrombosis and Haemostasis. 117:1338-1347
SummaryPlasminogen activator inhibitor 1 (PAI-1) is the main inhibitor of tissue-type and urokinase-type plasminogen activators (t/uPA) and plays an important role in fibrinolysis. Inhibition of PAI-1 activity prevents thrombosis and accelerates fibr
Autor:
Duo Zhang, Baohuan Lian, Ziwen Chen, Xiaotong Li, Chaochao Hu, Xiao-kun Zhang, Zhenfei Huang, Yi Zhu, Zhuoer Li, Zhiping Zeng, Mingyu Li, Hongyu Yu, Siwei Yan, Shuangzhou Peng, Ying Su, Qi Kang
Publikováno v:
European journal of medicinal chemistry. 177
Nur77, an orphan member of the nuclear receptor superfamily, plays an important role in the regulation of inflammatory processes. Our previous work found that celastrol, a pentacyclic triterpene, bound to Nur77 to inhibit inflammation in a Nur77-depe
Autor:
Jingmei Liang, Meichun Gao, Jie Zhang, Xiao-kun Zhang, Xiaohui Chen, Dongliang Zhang, Ying Su, Guoliang Bao, Xuhuang Tu, Shuangzhou Peng, Zhiping Zeng
Publikováno v:
European Journal of Medicinal Chemistry. 211:113020
Nur77, an orphan nuclear receptor, is a member of the nuclear receptor superfamily. Nur77 plays important roles in various biological processes. Previously we reported that BI1071(DIM-C-pPhCF3+MeSO3-), an oxidized form and methanesulfonate salt of (4
Publikováno v:
Analytica chimica acta. 1053
Plasminogen activator inhibitor-1 (PAI-1) is a labile molecule that exists in four different forms: active, latent, cleaved and target bound form. Although there have been many methods to measure the total PAI-1, the measurement of active form of PAI
tPA Point Mutation at Autolysis Loop Enhances Resistance to PAI-1 Inhibition and Catalytic Activity.
Publikováno v:
Thrombosis & Haemostasis; 2019, Vol. 119 Issue 1, p77-86, 10p