Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Shuanghua Hu"'
Autor:
Shuanghua Hu, Wendy Clarke, Yazhong Huang, John B. Hogan, Lawrence G. Iben, Graham S. Poindexter, Gail K. Mattson, Ling Chen, Guanglin Luo, John W. Russell, Ildiko Antal-Zimanyi
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:3814-3817
A convergent synthesis route for the heterocyclic modification of a novel bicyclo[3.1.0]hexane NPY1 antagonist 2 was developed and the structure activity relationship of these modifications on NPY1 binding is reported. Two heterocyclic analogs 9 and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::800f1807028db0439bba719aa1a01b3a
https://doi.org/10.1016/j.bmcl.2013.04.095
https://doi.org/10.1016/j.bmcl.2013.04.095
Autor:
Martin A. Lewis, Louis S. Chupak, Robert G. Gentles, Shuanghua Hu, Min Ding, Yazhong Huang, Xiaofan Zheng, Yuval Blat, Andrea McClure, Ryan Westphal
Publikováno v:
Bioorganicmedicinal chemistry. 24(7)
N-Benzylic-substituted glycine sulfonamides that reversibly inhibit diacylglycerol (DAG) lipases are reported. Detailed herein are the structure activity relationships, profiling characteristics and physico-chemical properties for the first reported
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e63ae0d200553eec7d772a4bac3e9f9
https://pubmed.ncbi.nlm.nih.gov/26917221
https://pubmed.ncbi.nlm.nih.gov/26917221
Autor:
Robert G. Gentles, Michael A. Poss, Tracey Fiedler, Ronald J. Knox, David G. Harden, Shuanghua Hu, Yazhong Huang, C. J. Andres, Nicholas J. Lodge, C. David Weaver, Katherine A. Grant-Young
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:5694-5697
An exploratory SAR study on a series of potent, non-apamin-displacing 4-(aminomethylaryl)pyrazolopyrimidine KCa channel blockers is described and their selectivity against KCa channel subtypes is reported. The most potent analog, 5-chloro-N-(thiophen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bea31396fd449f218df9992fbb861d4
https://doi.org/10.1016/j.bmcl.2008.08.026
https://doi.org/10.1016/j.bmcl.2008.08.026
Autor:
Michael R. Weed, Jeffrey M. Brown, Brett R. Beno, Ryan S. Westphal, Robert G. Gentles, John Watson, Yan Kong, Lisa Hunihan, Martin A. Lewis, Mary Ellen Cvijic, John E. Macor, Joanne J. Bronson, Meredith Ferrante, Thaddeus F. Molski, Ronald J. Knox, Andrew Alt, Angela Cacace, Kristin L. Rockwell, Shuanghua Hu, Adam Hendricson, Yazhong Huang
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 354(3)
The present studies represent the first published report of a dopamine D1 positive allosteric modulator (PAM). D1 receptors have been proposed as a therapeutic target for the treatment of cognitive deficits associated with schizophrenia. However, the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d604e231071ac7177ea3adadb9588803
https://pubmed.ncbi.nlm.nih.gov/26109678
https://pubmed.ncbi.nlm.nih.gov/26109678
Publikováno v:
Journal of Heterocyclic Chemistry. 42:661-667
A novel route to electron-deficient thienopyrrolones is disclosed. The target heterocycles are concisely constructed by condensation of activated α- or β-halo-substituted acrylonitriles, or ortho-substituted halo, cyano heterocycles with mercaptopy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1de254e28d3e18cc6a036aa852c6548
https://doi.org/10.1002/jhet.5570420427
https://doi.org/10.1002/jhet.5570420427
Publikováno v:
Chemistry - A European Journal. 3:1617-1628
N-Linked glycopeptides were synthesized by condensation of a highmannose anomeric amine bearing a pentasaccharide with aspartic-acid-containing tri- and pentapeptides through the agency of IIDQ. The pentasaccharide portion, corresponding to the „co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::38076ba856fcd28d1909a2639c6a2ae4
https://doi.org/10.1002/chem.19970031011
https://doi.org/10.1002/chem.19970031011
Autor:
Shuanghua, Hu, Yazhong, Huang, Yong-Jin, Wu, Huan, He, Katherine A, Grant-Young, Robert L, Bertekap, Valerie, Whiterock, Patrick, Brassil, Kimberley, Lentz, Prasanna, Sivaprakasam, David R, Langley, Ryan S, Westphal, Paul M, Scola
Publikováno v:
Bioorganicmedicinal chemistry. 22(5)
Comprehensive structure activity relationship (SAR) studies were conducted on a focused screening hit, 2-(methylthio)-3-(phenylsulfonyl)-4H-pyrido[1,2-a]pyrimidin-4-imine (1, IC50: 4.0 nM), as 5-HT6 selective antagonists. Activity was improved some 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::513af1c2e3df47726118c0f0fb929ff8
https://pubmed.ncbi.nlm.nih.gov/24495863
https://pubmed.ncbi.nlm.nih.gov/24495863
Autor:
Shuanghua Hu, Samuel J. Danishefsky, In Jong Kim, Ohyun Kwon,†,‡ and, John T. Randolph, Tae Kyo Park, Mark T. Bilodeau
Publikováno v:
Journal of the American Chemical Society. 118:11488-11500
The total synthesis of the Hakomori MBr1 antigen, heavily expressed on human breast tumors, is related. The construction involved the assembly of four glycals: (17 (twice), 18, 20, and 26) and an l-fucose derivative, 34. The sensitivity of the stereo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::24faddf98e369df7eb88ca19e6f447ad
https://doi.org/10.1021/ja962048b
https://doi.org/10.1021/ja962048b
Autor:
Shuanghua Hu, Yazhong Huang
Publikováno v:
Modern Drug Synthesis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f97c2de5456664d8a5cf604db3c52150
https://doi.org/10.1002/9780470768594.ch6
https://doi.org/10.1002/9780470768594.ch6
Publikováno v:
ChemInform. 29
N-Linked glycopeptides were synthesized by condensation of a highmannose anomeric amine bearing a pentasaccharide with aspartic-acid-containing tri- and pentapeptides through the agency of IIDQ. The pentasaccharide portion, corresponding to the „co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::689f8eb30d0f78cd3befda9474ff466b
https://doi.org/10.1002/chin.199804204
https://doi.org/10.1002/chin.199804204