Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Shuanghong Yan"'
Autor:
Wendong Jia, Chengzhen Hu, Yuqin Wang, Yuming Gu, Guangrui Qian, Xiaoyu Du, Liying Wang, Yao Liu, Jiao Cao, Shanyu Zhang, Shuanghong Yan, Panke Zhang, Jing Ma, Hong-Yuan Chen, Shuo Huang
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Monitoring single molecule chemical reactions can be difficult and nanopore based strategies which have shown promise are technically challenging. Here, the authors report on a technique which allows for the direct observation of different reactions
Externí odkaz:
https://doaj.org/article/404f3091298944429c2a4aaee5be01da
Autor:
Yuqin Wang, Xiaoyu Guan, Shanyu Zhang, Yao Liu, Sha Wang, Pingping Fan, Xiaoyu Du, Shuanghong Yan, Panke Zhang, Hong-Yuan Chen, Wenfei Li, Daoqiang Zhang, Shuo Huang
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Nanopores have been used for direct observation of RNA structure in native environments but have limited RNA differentiation capabilities. Here, the authors report on the use of Mycobacterium smegmatis porin A nanopores for the trapping and transloca
Externí odkaz:
https://doaj.org/article/345253368a684ae498349fa2adfed263
Autor:
Jiao Cao, Wendong Jia, Jinyue Zhang, Xiumei Xu, Shuanghong Yan, Yuqin Wang, Panke Zhang, Hong-Yuan Chen, Shuo Huang
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Engineered biological nanopores enable observation of single molecule chemistry events; however a cylindrical pore geometry can have undesired effects. The authors report a conical biological pore which was embedded with tetrachloroaurate(III) to all
Externí odkaz:
https://doaj.org/article/94823f338928445084725edff4f78e3a
Autor:
Jinyue Zhang, Shuanghong Yan, Le Chang, Weiming Guo, Yuqin Wang, Yu Wang, Panke Zhang, Hong-Yuan Chen, Shuo Huang
Publikováno v:
iScience, Vol 23, Iss 3, Pp - (2020)
Summary: MicroRNAs (miRNAs) are a class of short non-coding RNAs that function in RNA silencing and post-transcriptional gene regulation. However, direct characterization of miRNA is challenging due to its unique properties such as its low abundance,
Externí odkaz:
https://doaj.org/article/e715fba3d3d543e7a2f13cc339f5b3e5
Autor:
Yao Liu, Kefan Wang, Yuqin Wang, Liying Wang, Shuanghong Yan, Xiaoyu Du, Panke Zhang, Hong-Yuan Chen, Shuo Huang
Publikováno v:
Journal of the American Chemical Society. 144:757-768
Autor:
Yuqin Wang, Hong-Yuan Chen, Shuanghong Yan, Shuo Huang, Pingping Fan, Panke Zhang, Shanyu Zhang, Xiaoyu Du
Publikováno v:
Analytical Chemistry. 93:14161-14168
Blockers of pore-forming toxins (PFTs) limit bacterial virulence by blocking relevant channel proteins. However, screening of desired blockers from a large pool of candidate molecules is not a trivial task. Acknowledging its advantages of low cost, h
Autor:
Shuo Huang, Liying Wang, Jing Ma, Yao Liu, Guangrui Qian, Wendong Jia, Chengzhen Hu, Hong-Yuan Chen, Shanyu Zhang, Yuming Gu, Jiao Cao, Yuqin Wang, Panke Zhang, Shuanghong Yan, Xiaoyu Du
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Nature Communications
Nature Communications
Chemical reactions of single molecules, caused by rapid formation or breaking of chemical bonds, are difficult to observe even with state-of-the-art instruments. A biological nanopore can be engineered into a single molecule reactor, capable of detec
Autor:
Weiming Guo, Yuqin Wang, Liying Wang, Shuanghong Yan, Yao Liu, Panke Zhang, Shuo Huang, Jinyue Zhang, Fubo Ma, Yu Wang, Shanyu Zhang, Jiao Cao, Hong-Yuan Chen
Publikováno v:
Nano Letters. 21:6703-6710
Diverse functions of proteins, including synthesis, catalysis, and signaling, result from their highly variable amino acid sequences. The technology allowing for direct analysis of protein sequences, however, is still unsatisfactory. Recent developme
Autor:
Shuanghong Yan, Shuo Huang, Jiao Cao, Jinyue Zhang, Wenfei Li, Wendong Jia, Panke Zhang, Yuqin Wang, Shanyu Zhang, Hong-Yuan Chen
Publikováno v:
ACS Sensors. 6:2449-2456
Protein nanopores can be engineered as nanoreactors to investigate single-molecule chemical reactions. Recent studies have demonstrated that Mycobacterium smegmatis porin A (MspA) nanopore is a superior engineering template acknowledging its geometri
Autor:
Xiaoyu Du, Hong-Yuan Chen, Pingping Fan, Shuo Huang, Daoqiang Zhang, Yuqin Wang, Shuanghong Yan, Yao Liu, Wenfei Li, Panke Zhang, Sha Wang, Xiaoyu Guan, Shanyu Zhang
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Nature Communications
Nature Communications
Folding of RNA can produce elaborate tertiary structures, corresponding to their diverse roles in the regulation of biological activities. Direct observation of RNA structures at high resolution in their native form however remains a challenge. The l