Zobrazeno 1 - 10
of 74
pro vyhledávání: '"Shuang-Hu Wang"'
Autor:
Shuang-Hu Wang, Shi-Qiang Wei, Ye Zhang, Xiao-Ming Zhang, Shu-Yu Zhang, Kun-Long Dai, Yong-Qiang Tu, Ka Lu, Tong-Mei Ding
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-7 (2024)
Abstract Bridged chiral biaryls are axially chiral compounds with a medium-sized ring connecting the two arenes. Compared with plentiful methods for the enantioselective synthesis of biaryl compounds, synthetic approaches for this subclass of bridged
Externí odkaz:
https://doaj.org/article/57e680085e304e70a3ddd82d51daf12b
Autor:
Shan Zhou, Fang-Ling Zhao, Shuang-Hu Wang, Yi-Ran Wang, Yun Hong, Quan Zhou, Pei-Wu Geng, Qing-Feng Luo, Jian-Ping Cai, Da-Peng Dai
Publikováno v:
Pharmaceutical Biology, Vol 61, Iss 1, Pp 356-361 (2023)
AbstractContext Poziotinib and vonoprazan are two drugs mainly metabolized by CYP3A4. However, the drug-drug interaction between them is unknown.Objective To study the interaction mechanism and pharmacokinetics of poziotinib on vonoprazan.Materials a
Externí odkaz:
https://doaj.org/article/79a4ba7b298642aaa32f83b48285d136
Autor:
Li-Li Zou, Fang-Ling Zhao, Yu-Ying Qi, Shuang-Hu Wang, Quan Zhou, Pei-Wu Geng, Yun-Fang Zhou, Qing Zhang, Hao Chen, Da-Peng Dai, Jian-Ping Cai, Fu-Sui Ji
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Genetic polymorphism of the cytochrome P450 (CYP) gene can significantly influence the metabolism of endogenous and xenobiotic compounds. However, few studies have focused on the polymorphism of CYP2J2 and its impact on drug catalytic activity, espec
Externí odkaz:
https://doaj.org/article/0762e0c80a9d4f7091733ca8585dcee7
Autor:
Fang-Ling Zhao, Qing Zhang, Shuang-Hu Wang, Yun Hong, Shan Zhou, Quan Zhou, Pei-Wu Geng, Qing-Feng Luo, Jie-Fu Yang, Hao Chen, Jian-Ping Cai, Da-Peng Dai
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Cytochrome 2C9 (CYP2C9), one of the most important drug metabolic enzymes in the human hepatic P450 superfamily, is required for the metabolism of 15% of clinical drugs. Similar to other CYP2C family members, CYP2C9 gene has a high genetic polymorphi
Externí odkaz:
https://doaj.org/article/82e7e3b0ff074e13897a7243a48384c2
Autor:
Jian Liu, Hao Chen, Shuang‐Hu Wang, Quan Zhou, Pei‐Wu Geng, Yun‐Fang Zhou, Hua‐Lan Wu, Hai‐Feng Shi, Fang Wang, Jie‐Fu Yang, Jian‐Ping Cai, Da‐Peng Dai
Publikováno v:
Pharmacology Research & Perspectives, Vol 9, Iss 1, Pp n/a-n/a (2021)
Abstract Cytochrome P450 2C9 (CYP2C9) is one of the most important drugs metabolizing enzymes and accounts for the metabolism of about 13%–17% of clinical drugs. Like other members in CYP2 family, CYP2C9 gene exhibits great genetic polymorphism amo
Externí odkaz:
https://doaj.org/article/eccf81e4a97a46aab0c14e33eab9a56f
Autor:
Yun Hong, Da-Peng Dai, Jian-Ping Cai, Shuang-Hu Wang, Yi-Ran Wang, Fang-Ling Zhao, Shan Zhou, Quan Zhou, Pei-Wu Geng, Yun-Fang Zhou, Xue Xu, Ji-Hua Shi, Qing-Feng Luo
Publikováno v:
Drug Design, Development and Therapy.
Yun Hong,1,* Da-Peng Dai,2,* Jian-Ping Cai,2 Shuang-Hu Wang,3 Yi-Ran Wang,1,4 Fang-Ling Zhao,2,4 Shan Zhou,2 Quan Zhou,3 Pei-Wu Geng,3 Yun-Fang Zhou,3 Xue Xu,1 Ji-Hua Shi,1 Qing-Feng Luo1 1Department of Gastroenterology, Beijing Hospital, Nat
Autor:
Shun-Bin Luo, Chuan-Bao Li, Da-Peng Dai, Shuang-Hu Wang, Zhen-He Wang, Pei-Wu Geng, Jie Cai, Zhe-Li Jiang, Cheng-Wei Pu, Ke Shang, Xin-Min Yuan, Ya-Po Cao, Guo-Xin Hu, Jian-Ping Cai
Publikováno v:
Journal of Pharmacological Sciences, Vol 125, Iss 2, Pp 150-156 (2014)
Abstract.: Warfarin is the most frequently prescribed anticoagulant for the long-term treatment in the clinic. Recent studies have shown that polymorphic alleles within the CYP2C9, VKORC1, and CYP4F2 genes are related to the warfarin dosage requireme
Externí odkaz:
https://doaj.org/article/ca8b0de2b96044acb05474074d26c394
Autor:
Fu-Min Zhang, Xiang Guo, Yong-Yao Li, Shuang-Hu Wang, Xiao-Ming Zhang, Yong-Qiang Tu, Bao-Sheng Li
Publikováno v:
Organic Chemistry Frontiers. 8:2510-2514
A concise method of synthesizing the tetracyclic core of annotinolide C has been developed. The key steps include a tandem epoxidation/semipinacol rearrangement step to construct a quaternary aza [6.5] spiro ring (rings A and B), an intramolecular al
Autor:
Shuang‐Hu Wang, Rui‐Qi Si, Qing‐Bo Zhuang, Xiang Guo, Tian Ke, Xiao‐Ming Zhang, Fu‐Min Zhang, Yong‐Qiang Tu
Publikováno v:
Angewandte Chemie. 132:22138-22142
Autor:
Xiao-Ming Zhang, Tian Ke, Fu-Min Zhang, Qing-Bo Zhuang, Yong-Qiang Tu, Xiang Guo, Rui-Qi Si, Shuang-Hu Wang
Publikováno v:
Angewandte Chemie International Edition. 59:21954-21958
A tandem Bischler-Napieralski/semipinacol rearrangement reaction has been developed for the purpose of assembling a bis(spirocyclic) indole framework, a privileged structural unit of aspidofractinine-type monoterpenoid indole alkaloids, and was used