Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Shuang Mo"'
USP14 promotes tryptophan metabolism and immune suppression by stabilizing IDO1 in colorectal cancer
Autor:
Dongni Shi, Xianqiu Wu, Yunting Jian, Junye Wang, Chengmei Huang, Shuang Mo, Yue Li, Fengtian Li, Chao Zhang, Dongsheng Zhang, Huizhong Zhang, Huilin Huang, Xin Chen, Y. Alan Wang, Chuyong Lin, Guozhen Liu, Libing Song, Wenting Liao
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
IDO1-mediated tryptophan metabolism plays an important role in creating an immunosuppressive tumour microenvironment. Here, the authors show that deubiquitinase USP14 regulates immune suppression by inducing IDO1 stabilization and suggest USP14 as a
Externí odkaz:
https://doaj.org/article/da0e7849fcb34a24976064852f9e4e8c
Autor:
Muwen Yang, Yue Li, Lingzhi Kong, Shumei Huang, Lixin He, Pian Liu, Shuang Mo, Xiuqing Lu, Xi Lin, Yunyun Xiao, Dongni Shi, Xinjian Huang, Boyu Chen, Xiangfu Chen, Ying Ouyang, Jun Li, Chuyong Lin, Libing Song
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 14 (2023)
Human epidermal growth factor receptor 2–targeted (HER2-targeted) therapy is the mainstay of treatment for HER2+ breast cancer. However, the proteolytic cleavage of HER2, or HER2 shedding, induces the release of the target epitope at the ectodomain
Externí odkaz:
https://doaj.org/article/593b29f705e24849b965253f87a0ae35
Autor:
Shuxia Zhang, Xinyi Liao, Suwen Chen, Wanying Qian, Man Li, Yingru Xu, Meisongzhu Yang, Xincheng Li, Shuang Mo, Miaoling Tang, Xingui Wu, Yameng Hu, Ziwen Li, Ruyuan Yu, Ainiwaerjiang Abudourousuli, Libing Song, Jun Li
Publikováno v:
Advanced Science, Vol 9, Iss 31, Pp n/a-n/a (2022)
Abstract Tumor‐derived extracellular vesicles (EVs) function as critical mediators in selective modulation of the microenvironment of distant organs to generate a pre‐metastatic niche that facilitates organotropic metastasis. Identifying the orga
Externí odkaz:
https://doaj.org/article/9ed1e6d25f6045258878b7096a1c589e
Autor:
Shuxia Zhang, Yingru Xu, Chan Xie, Liangliang Ren, Geyan Wu, Meisongzhu Yang, Xingui Wu, Miaoling Tang, Yameng Hu, Ziwen Li, Ruyuan Yu, Xinyi Liao, Shuang Mo, Jueheng Wu, Mengfeng Li, Erwei Song, Yanfei Qi, Libing Song, Jun Li
Publikováno v:
Advanced Science, Vol 8, Iss 16, Pp n/a-n/a (2021)
Externí odkaz:
https://doaj.org/article/9bbd438b6cab48c0b52ddd961b869362
Autor:
Lixue Cao, Geyan Wu, Jinrong Zhu, Zhanyao Tan, Dongni Shi, Xingui Wu, Miaoling Tang, Ziwen Li, Yameng Hu, Shuxia Zhang, Ruyuan Yu, Shuang Mo, Jueheng Wu, Erwei Song, Mengfeng Li, Libing Song, Jun Li
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
It is known that genotoxic stress induces high levels of ROS and deplete cellular glutathione stores. Here, Cao et al. uncover a β-catenin-dependent TCF/LEF-independent mechanism that promotes histone-mediated transcriptional activation of glutathio
Externí odkaz:
https://doaj.org/article/ffab176b40414791a1654754dbf0a80b
Autor:
Ziwen Li, Xinyi Liao, Yameng Hu, Man Li, Miaoling Tang, Shuxia Zhang, Shuang Mo, Xincheng Li, Suwen Chen, Wanying Qian, Rongni Feng, Ruyuan Yu, Yingru Xu, Shuanghu Yuan, Chan Xie, Jun Li
Publikováno v:
Free Radical Biology and Medicine. 201:41-54
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7288b9c0bdb0a6e9e4e69bf295c7cf3f
https://doi.org/10.1016/j.freeradbiomed.2023.03.013
https://doi.org/10.1016/j.freeradbiomed.2023.03.013
Autor:
Libing Song, Jun Li, Xinyi Liao, Ziwen Li, Yingru Xu, Yameng Hu, Ruyuan Yu, Shuxia Zhang, Xingui Wu, Shuang Mo, Geyan Wu, Meisongzhu Yang, Miaoling Tang
Mitochondrial dynamics play vital roles in the tumorigenicity and malignancy of various types of cancers by promoting the tumor-initiating potential of cancer cells, suggesting that targeting crucial factors that drive mitochondrial dynamics may lead
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63ec0c6ee2e0bac36743ab5aa046ed07
https://doi.org/10.1158/0008-5472.c.6513055
https://doi.org/10.1158/0008-5472.c.6513055
Autor:
Libing Song, Jun Li, Xinyi Liao, Ziwen Li, Yingru Xu, Yameng Hu, Ruyuan Yu, Shuxia Zhang, Xingui Wu, Shuang Mo, Geyan Wu, Meisongzhu Yang, Miaoling Tang
This document contains Supplemental Materials and Methods and Supplementary Data
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21a6d2d5f9d89f20e3b4872f8354d2ca
https://doi.org/10.1158/0008-5472.22428529
https://doi.org/10.1158/0008-5472.22428529
Autor:
Xinyi Liao, Ziwen Li, Yameng Hu, Ruyuan Yu, Xingui Wu, Shuang Mo, Libing Song, Geyan Wu, Miaoling Tang, Meisongzhu Yang, Shuxia Zhang, Yingru Xu, Jun Li
Publikováno v:
Cancer Research. 81:3835-3848
Mitochondrial dynamics play vital roles in the tumorigenicity and malignancy of various types of cancers by promoting the tumor-initiating potential of cancer cells, suggesting that targeting crucial factors that drive mitochondrial dynamics may lead
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76a5712320c21ecbf7203ac6729514f4
https://doi.org/10.1158/0008-5472.can-21-0436
https://doi.org/10.1158/0008-5472.can-21-0436
USP14 promotes tryptophan metabolism and immune suppression by stabilizing IDO1 in colorectal cancer
Autor:
Dongni Shi, Xianqiu Wu, Yunting Jian, Junye Wang, Chengmei Huang, Shuang Mo, Yue Li, Fengtian Li, Chao Zhang, Dongsheng Zhang, Huizhong Zhang, Huilin Huang, Xin Chen, Y. Alan Wang, Chuyong Lin, Guozhen Liu, Libing Song, Wenting Liao
Publikováno v:
Nature communications. 13(1)
Indoleamine 2,3 dioxygenase 1 (IDO1) is an attractive target for cancer immunotherapy. However, IDO1 inhibitors have shown disappointing therapeutic efficacy in clinical trials, mainly because of the activation of the aryl hydrocarbon receptor (AhR).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::753d3a2c8403a577cdb7c136453f06e5
https://pubmed.ncbi.nlm.nih.gov/36163134
https://pubmed.ncbi.nlm.nih.gov/36163134