Zobrazeno 1 - 10
of 182
pro vyhledávání: '"Shuang G Zhao"'
Autor:
Matthew J Schiewer, Amy C Mandigo, Nicolas Gordon, Fangjin Huang, Sanchaika Gaur, Renée de Leeuw, Shuang G Zhao, Joseph Evans, Sumin Han, Theodore Parsons, Ruth Birbe, Peter McCue, Christopher McNair, Saswati N Chand, Ylenia Cendon‐Florez, Peter Gallagher, Jennifer J McCann, Neermala Poudel Neupane, Ayesha A Shafi, Emanuela Dylgjeri, Lucas J Brand, Tapio Visakorpi, Ganesh V Raj, Costas D Lallas, Edouard J Trabulsi, Leonard G Gomella, Adam P Dicker, Wm. Kevin Kelly, Benjamin E Leiby, Beatrice Knudsen, Felix Y Feng, Karen E Knudsen
Publikováno v:
EMBO Molecular Medicine, Vol 10, Iss 12, Pp 1-20 (2018)
Abstract PARP‐1 holds major functions on chromatin, DNA damage repair and transcriptional regulation, both of which are relevant in the context of cancer. Here, unbiased transcriptional profiling revealed the downstream transcriptional profile of P
Externí odkaz:
https://doaj.org/article/044d966fd25b4793a1abaa4247be3583
Autor:
Hamza Bakhtiar, Marina N. Sharifi, Kyle T. Helzer, Yue Shi, Matthew L. Bootsma, Tianfu A. Shang, Matthew R. Chrostek, Tracy J. Berg, S. Carson Callahan, Viridiana Carreno, Grace C. Blitzer, Malinda T. West, Ruth M. O’Regan, Kari B. Wisinski, Martin Sjöström, Shuang G. Zhao
Publikováno v:
npj Precision Oncology, Vol 8, Iss 1, Pp 1-10 (2024)
Abstract In preclinical studies, p53 loss of function impacts chemotherapy response, but this has not been consistently validated clinically. We trained a TP53-loss phenocopy gene expression signature from pan-cancer clinical samples in the TCGA. In
Externí odkaz:
https://doaj.org/article/b735ca97c9414b91b5344298927abc08
Autor:
Nicholas R. Rydzewski, Yue Shi, Chenxuan Li, Matthew R. Chrostek, Hamza Bakhtiar, Kyle T. Helzer, Matthew L. Bootsma, Tracy J. Berg, Paul M. Harari, John M. Floberg, Grace C. Blitzer, David Kosoff, Amy K. Taylor, Marina N. Sharifi, Menggang Yu, Joshua M. Lang, Krishnan R. Patel, Deborah E. Citrin, Kaitlin E. Sundling, Shuang G. Zhao
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-12 (2024)
Abstract Histopathologic diagnosis and classification of cancer plays a critical role in guiding treatment. Advances in next-generation sequencing have ushered in new complementary molecular frameworks. However, existing approaches do not independent
Externí odkaz:
https://doaj.org/article/27df8447126a4b8db5d9d92bb0d0f133
Autor:
Shuang G Zhao, Mark Shilkrut, Corey Speers, Meilan Liu, Kari Wilder-Romans, Theodore S Lawrence, Lori J Pierce, Felix Y Feng
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0126631 (2015)
PURPOSE:The molecular drivers of metastasis in breast cancer are not well understood. Therefore, we sought to identify the biological processes underlying distant progression and define a prognostic signature for metastatic potential in breast cancer
Externí odkaz:
https://doaj.org/article/c0c648db6e0d4cecab3708e40ad5a5b3
Autor:
Shuang G. Zhao, Jamie M. Sperger, Jennifer L. Schehr, Rana R. McKay, Hamid Emamekhoo, Anupama Singh, Zachery D. Schultz, Rory M. Bade, Charlotte N. Stahlfeld, Cole S. Gilsdorf, Camila I. Hernandez, Serena K. Wolfe, Richel D. Mayberry, Hannah M. Krause, Matt Bootsma, Kyle T. Helzer, Nicholas Rydzewski, Hamza Bakhtiar, Yue Shi, Grace Blitzer, Christos E. Kyriakopoulos, David Kosoff, Xiao X. Wei, John Floberg, Nan Sethakorn, Marina Sharifi, Paul M. Harari, Wei Huang, Himisha Beltran, Toni K. Choueiri, Howard I. Scher, Dana E. Rathkopf, Susan Halabi, Andrew J. Armstrong, David J. Beebe, Menggang Yu, Kaitlin E. Sundling, Mary-Ellen Taplin, Joshua M. Lang
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 21 (2022)
Background Neuroendocrine prostate cancer (NEPC) is an aggressive subtype, the presence of which changes the prognosis and management of metastatic prostate cancer.Methods We performed analytical validation of a Circulating Tumor Cell (CTC) multiplex
Externí odkaz:
https://doaj.org/article/ec5e2f5145314e94b0c25808c0d5eee0
Autor:
Nicholas R. Rydzewski, MD, MPH, Poonam Yadav, PhD, Hima Bindu Musunuru, MD, FRCR, Kevin M. Condit, MA, David Francis, MD, Shuang G. Zhao, MD, MSE, Andrew M. Baschnagel, MD
Publikováno v:
Advances in Radiation Oncology, Vol 7, Iss 3, Pp 100884- (2022)
Purpose: Our purpose was to determine whether bone density and bone-derived radiomic metrics in combination with dosimetric variables could improve risk stratification of rib fractures after stereotactic body radiation therapy (SBRT) for early-stage
Externí odkaz:
https://doaj.org/article/18738b74faa7450c8384300574ba1ab8
Autor:
Jamie M. Sperger, Kyle T. Helzer, Charlotte N. Stahlfeld, Dawei Jiang, Anupama Singh, Katherine R. Kaufmann, David J. Niles, Erika Heninger, Nicholas R. Rydzewski, Liguo Wang, Liewei Wang, Rendong Yang, Yanan Ren, Jonathan W. Engle, Peng Huang, Christos E. Kyriakopoulos, Susan F. Slovin, Howard R. Soule, Shuang G. Zhao, Manish Kohli, Scott T. Tagawa, Weibo Cai, Scott M. Dehm, Joshua M. Lang
Publikováno v:
Clinical Cancer Research. :OF1-OF12
Purpose: Men with metastatic castration-resistant prostate cancer (mCRPC) frequently develop resistance to androgen receptor signaling inhibitor (ARSI) treatment; therefore, new therapies are needed. Trophoblastic cell-surface antigen (TROP-2) is a t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2a6499da8242b249df8a969609dc3f5c
https://doi.org/10.1158/1078-0432.ccr-22-1305
https://doi.org/10.1158/1078-0432.ccr-22-1305
Figure S1 from Expression and Therapeutic Targeting of TROP-2 in Treatment-Resistant Prostate Cancer
Autor:
Joshua M. Lang, Scott M. Dehm, Weibo Cai, Scott T. Tagawa, Manish Kohli, Shuang G. Zhao, Howard R. Soule, Susan F. Slovin, Christos E. Kyriakopoulos, Peng Huang, Jonathan W. Engle, Yanan Ren, Rendong Yang, Liewei Wang, Liguo Wang, Nicholas R. Rydzewski, Erika Heninger, David J. Niles, Katherine R. Kaufmann, Anupama Singh, Dawei Jiang, Charlotte N. Stahlfeld, Kyle T. Helzer, Jamie M. Sperger
Figure S1. Correlation of TACSTD2 with Prostate Cancer Cell Surface Markers.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0364775d8422639e4ff292c0b654309b
https://doi.org/10.1158/1078-0432.22709374.v1
https://doi.org/10.1158/1078-0432.22709374.v1
Autor:
Joshua M. Lang, Scott M. Dehm, Weibo Cai, Scott T. Tagawa, Manish Kohli, Shuang G. Zhao, Howard R. Soule, Susan F. Slovin, Christos E. Kyriakopoulos, Peng Huang, Jonathan W. Engle, Yanan Ren, Rendong Yang, Liewei Wang, Liguo Wang, Nicholas R. Rydzewski, Erika Heninger, David J. Niles, Katherine R. Kaufmann, Anupama Singh, Dawei Jiang, Charlotte N. Stahlfeld, Kyle T. Helzer, Jamie M. Sperger
Purpose:Men with metastatic castration-resistant prostate cancer (mCRPC) frequently develop resistance to androgen receptor signaling inhibitor (ARSI) treatment; therefore, new therapies are needed. Trophoblastic cell-surface antigen (TROP-2) is a tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a729fb1c7750209131d490ea6d1d7bfd
https://doi.org/10.1158/1078-0432.c.6620176.v1
https://doi.org/10.1158/1078-0432.c.6620176.v1
Autor:
Weihua Zhou, Zitong Zhao, Angelica Lin, John Yang, Jie Xu, Wilder-Romans Kari, Annabel Yang, Jing Li, Sumeet Solanki, Jennifer Speth, Natalie Walker, Andrew J. Scott, Ayesha U. Kothari, Yangyang Yao, Erik R. Peterson, Navyateja Korimerla, Christian K. Werner, Jessica Liang, Janna Jacobson, Sravya Palavalasa, Alexandra M. Obrien, Ameer L. Elaimy, Sean P. Ferris, Shuang G. Zhao, Jann N. Sarkaria, Balázs Győrffy, Shuqun Zhang, Wajd N Al-Holou, Yoshie Umemura, Meredith A. Morgan, Theodore S. Lawrence, Costas A. Lyssiotis, Marc Peters-Golden, Yatrik M. Shah, Daniel R. Wahl
Publikováno v:
bioRxiv
How cell metabolism regulates DNA repair is incompletely understood. Here, we define a GTP-mediated signaling cascade that links metabolism to DNA repair and has significant therapeutic implications. GTP, but not other nucleotides, regulates the acti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b47dac35ff3bc7bc06b90f06a038189a
https://europepmc.org/articles/PMC10120670/
https://europepmc.org/articles/PMC10120670/