Design, Synthesis and Biological Evaluation of Novel Bromophenol Derivatives Incorporating Indolin-2-One Moiety as Potential Anticancer Agents

Autor: Li-Jun Wang, Shuai-Yu Wang, Bo Jiang, Ning Wu, Xiang-Qian Li, Bao-Cheng Wang, Jiao Luo, Meng Yang, Shui-Hua Jin, Da-Yong Shi

Publikováno v: Marine Drugs, Vol 13, Iss 2, Pp 806-823 (2015)

A series of bromophenol derivatives containing indolin-2-one moiety were designed and evaluated that for their anticancer activities against A549, Bel7402, HepG2, HeLa and HCT116 cancer cell lines using MTT assay in vitro. Among them, seven compounds

Externí odkaz: https://doaj.org/article/bbb4ed7b494a42648fef3bad6faee560

Discovery of Novel Bromophenol Hybrids as Potential Anticancer Agents through the Ros-Mediated Apoptotic Pathway: Design, Synthesis and Biological Evaluation

Autor: Li-Jun Wang, Chuan-Long Guo, Xiang-Qian Li, Shuai-Yu Wang, Bo Jiang, Yue Zhao, Jiao Luo, Kuo Xu, Hua Liu, Shu-Ju Guo, Ning Wu, Da-Yong Shi

Publikováno v: Marine Drugs, Vol 15, Iss 11, p 343 (2017)

A series of bromophenol hybrids with N-containing heterocyclic moieties were designed, and their anticancer activities against a panel of five human cancer cell lines (A549, Bel7402, HepG2, HCT116 and Caco2) using MTT assay in vitro were explored. Am

Externí odkaz: https://doaj.org/article/10d1a6beefa34e0782325febcf410c6e

Discovery of Novel Bromophenol–Thiosemicarbazone Hybrids as Potent Selective Inhibitors of Poly(ADP-ribose) Polymerase-1 (PARP-1) for Use in Cancer

Autor: Xiangqian Li, Xuemin Yu, Kuo Xu, Yue Zhao, Bo Jiang, Shuai-Yu Wang, Dayong Shi, Xiuxue Li, Chuanlong Guo, Jiao Luo, Lijun Wang

Publikováno v: Journal of Medicinal Chemistry. 62:3051-3067

Poly(ADP-ribose) polymerase-1 (PARP-1) is a new potential target for anticancer drug discovery. A series of bromophenol–thiosemicarbazone hybrids as PARP-1 inhibitors were designed, synthesized, and evaluated for their antitumor activities. Among t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91537a65390a992592d2373f606ecfe0
https://doi.org/10.1021/acs.jmedchem.8b01946

Anti-Angiogenic Properties of BDDPM, a Bromophenol from Marine Red Alga Rhodomela confervoides, with Multi Receptor Tyrosine Kinase Inhibition Effects

Autor: Ning Wu, Bo Jiang, Shuai-Yu Wang, Shaofang Liu, Jiao Luo, Xiangqian Li, Lijun Wang, Dayong Shi

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 16, Iss 6, Pp 13548-13560 (2015)
Volume 16
Issue 6
Pages 13548-13560

Bis-(2,3-dibromo-4,5-dihydroxy-phenyl)-methane (BDDPM) is a bromophenol first isolated from Rhodomelaceae confervoides. Our previous studies showed that BDDPM exerts PTP1B-inhibiting activity and anti-cancer activity against a wide range of tumor cel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::413f8176c67e0107b4b93784a79fdae4
http://europepmc.org/articles/PMC4490508

Marine Bromophenol Bis (2,3-Dibromo-4,5-dihydroxy-phenyl)-methane Inhibits the Proliferation, Migration, and Invasion of Hepatocellular Carcinoma Cells via Modulating β1-Integrin/FAK Signaling

Autor: Changhui Wang, Dayong Shi, Changqing Fu, Jian Jian Li, Bo Jiang, Lijun Wang, Ning Wu, Jiao Luo, Shuai-Yu Wang

Publikováno v: Marine Drugs, Vol 13, Iss 2, Pp 1010-1025 (2015)
Marine Drugs
Volume 13
Issue 2
Pages: 1010-1025

Bis (2,3-dibromo-4,5-dihydroxy-phenyl)-methane (BDDPM) is a natural bromophenol compound derived from marine algae. Previous reports have shown that BDDPM possesses antimicrobial activity. In the present study, we found that BDDPM has cytotoxic activ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2367f61a827d702e31b1d1cfa33d35fe
http://www.mdpi.com/1660-3397/13/2/1010