Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Shu-ru Kuo"'
Publikováno v:
PLoS ONE, Vol 5, Iss 10, p e13335 (2010)
OBJECTIVES: Anthrax infection is associated with devastating cardiovascular sequelae, suggesting unfavorable cardiovascular effects of toxins originated from Bacillus anthracis namely lethal and edema toxins. This study was designed to examine the di
Externí odkaz:
https://doaj.org/article/48c648572bdd4b279884925084e39fa6
Autor:
Linley E Watson, Shu-Ru Kuo, Khurshed Katki, Tongyun Dang, Seong Kyu Park, David E Dostal, Wei-Jen Tang, Stephen H Leppla, Arthur E Frankel
Publikováno v:
PLoS ONE, Vol 2, Iss 5, p e466 (2007)
Anthrax infections are frequently associated with severe and often irreversible hypotensive shock. The isolated toxic proteins of Bacillus anthracis produce a non-cytokine-mediated hypotension in rats by unknown mechanisms. These observations suggest
Externí odkaz:
https://doaj.org/article/5852b824721a42d18655ae1e0f2fc452
Publikováno v:
Anti-Cancer Agents in Medicinal Chemistry. 11:983-992
Tumor growth depends upon access to host blood vessels. Many steps in tumor angiogenesis have been defined including tumor cell hypoxia, tumor cell secretion of pro-angiogenic growth factors, receptor activation on host endothelium and stroma, and es
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14940dd171dcb2dd49abcbc3fcc6c567
https://doi.org/10.2174/187152011797927643
https://doi.org/10.2174/187152011797927643
Publikováno v:
Bioconjugate Chemistry. 20:1975-1982
Immunotoxin potency is dependent on cell surface binding specificity as well as internalization efficiency. Current approaches for immunotoxin development are dependent on existing antibodies that were selected for high affinity and/or high productio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb342934e5cd719fbd45915dd275d850
https://doi.org/10.1021/bc900333j
https://doi.org/10.1021/bc900333j
Autor:
Arthur E. Frankel, Mark C. Willingham, Carney Jackson, Sarah H. Bour, Nicholas S. Duesbery, Wei-Jen Tang, Stephen H. Leppla, Shu Ru Kuo, Seong Kyu Park, Elissa A. Andreas
Publikováno v:
Microbial Pathogenesis. 44:467-472
Bacillus anthracis infections are frequently associated with severe and often irreversible hypotensive shock despite appropriate antibiotics and aggressive hemodynamic and pulmonary support. Based on the observations that the anthrax secreted protein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99f476c6df91375f369b547f05255f19
https://doi.org/10.1016/j.micpath.2007.12.001
https://doi.org/10.1016/j.micpath.2007.12.001
Comparison of checkpoint responses triggered by DNA polymerase inhibition versus DNA damaging agents
Publikováno v:
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 532:215-226
To better understand the different cellular responses to replication fork pausing versus blockage, early DNA damage response markers were compared after treatment of cultured mammalian cells with agents that either inhibit DNA polymerase activity (hy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb200e494452885231a2783ed982838b
https://doi.org/10.1016/j.mrfmmm.2003.08.018
https://doi.org/10.1016/j.mrfmmm.2003.08.018
Publikováno v:
Biochemistry. 40:14661-14668
Treatment of cells with the enediyne C-1027 is highly efficient at inducing single- and double-strand DNA breaks. This agent is highly cytotoxic when used at picomolar levels over a period of days. For this study, C-1027 has been used at higher level
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6953d05b83acedf2449feca321ff0609
https://doi.org/10.1021/bi015680c
https://doi.org/10.1021/bi015680c
Publikováno v:
Journal of Biological Chemistry. 275:1391-1397
The cyclopropylpyrroloindole anti-cancer drug, adozelesin, binds to and alkylates DNA. Treatment of human cells with low levels of adozelesin results in potent inhibition of both cellular and simian virus 40 (SV40) DNA replication. Extracts were prep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2bf9548e98bb9800f8fda51c0030158
https://doi.org/10.1074/jbc.275.2.1391
https://doi.org/10.1074/jbc.275.2.1391
Autor:
Mary M. McHugh, Mary H. Walsh-O'Beirne, Jen-Sing Liu, Shu-Ru Kuo, Thomas Melendy, Terry A. Beerman
Publikováno v:
Biochemistry. 38:11508-11515
Bizelesin, a bifunctional DNA minor groove alkylating agent, inhibits both cellular and viral (SV40) DNA replication in whole cells. Bizelesin inhibition of SV40 DNA replication was analyzed in SV40-infected cells, using two-dimensional (2D) neutral
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c114b0c47e26d7f1b39f14c25e911eee
https://doi.org/10.1021/bi990598r
https://doi.org/10.1021/bi990598r
Publikováno v:
Journal of Biological Chemistry. 274:2696-2705
Papovaviruses are valuable models for the study of DNA replication in higher eukaryotic organisms, as they depend on host factors for replication of their DNA. In this study we investigate the interactions between the human papillomavirus type 11 (HP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f53e9f951ea619e8fe9f5768bcfc0944
https://doi.org/10.1074/jbc.274.5.2696
https://doi.org/10.1074/jbc.274.5.2696