Zobrazeno 1 - 10
of 101
pro vyhledávání: '"Shu-Ichi Matsuzawa"'
Autor:
Tomonori Hoshino, Atsushi Mukai, Hirofumi Yamashita, Hidemi Misawa, Makoto Urushitani, Yoshitaka Tashiro, Shu-ichi Matsuzawa, Ryosuke Takahashi
Publikováno v:
Molecular Brain, Vol 17, Iss 1, Pp 1-4 (2024)
Abstract Protein turnover is crucial for cell survival, and the impairment of proteostasis leads to cell death. Aging is associated with a decline in proteostasis, as the progressive accumulation of damaged proteins is a hallmark of age-related disor
Externí odkaz:
https://doaj.org/article/bfb7ac35605849319db0cacb21ff7e5e
Autor:
Tomoyuki Ishimoto, Miki Oono, Seiji Kaji, Takashi Ayaki, Katsuya Nishida, Itaru Funakawa, Takakuni Maki, Shu-ichi Matsuzawa, Ryosuke Takahashi, Hodaka Yamakado
Publikováno v:
Molecular Brain, Vol 17, Iss 1, Pp 1-13 (2024)
Abstract The aggregated alpha-synuclein (αsyn) in oligodendrocytes (OLGs) is one of the pathological hallmarks in multiple system atrophy (MSA). We have previously reported that αsyn accumulates not only in neurons but also in OLGs long after the a
Externí odkaz:
https://doaj.org/article/cd30b625e77b48f48134f51505938d29
Autor:
Masanori Sawamura, Kiyoshi Tachikawa, Rie Hikawa, Hisako Akiyama, Seiji Kaji, Ken Yasuda, Angel I. Leu, Hyojung Hong, Rajesh Mukthavaram, Pad Chivukula, Hodaka Yamakado, Yoshio Hirabayashi, Ryosuke Takahashi, Shu-ichi Matsuzawa
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 35, Iss 4, Pp 102380- (2024)
Despite the wide range of applications of mRNA therapies, major difficulties exist in the efficient delivery of mRNA into oligodendrocytes, a type of glial cell in the brain. Commonly used viral vectors are not efficient in transforming oligodendrocy
Externí odkaz:
https://doaj.org/article/a690f55095224122b98cf44013d30ce2
Autor:
Etsuro Nakanishi, Norihito Uemura, Hisako Akiyama, Masato Kinoshita, Sawamura Masanori, Yosuke Taruno, Hodaka Yamakado, Shu-ichi Matsuzawa, Shunichi Takeda, Yoshio Hirabayashi, Ryosuke Takahashi
Publikováno v:
Molecular Brain, Vol 14, Iss 1, Pp 1-15 (2021)
Abstract Homozygous mutations in the lysosomal glucocerebrosidase gene, GBA1, cause Gaucher’s disease (GD), while heterozygous mutations in GBA1 are a strong risk factor for Parkinson’s disease (PD), whose pathological hallmark is intraneuronal
Externí odkaz:
https://doaj.org/article/4dcda80e219b4d179a2bdf0bf1201e92
Publikováno v:
FEBS Open Bio, Vol 10, Iss 9, Pp 1758-1764 (2020)
Ferroptosis, a form of iron‐dependent cell death caused by lipid peroxidation, has been implicated in neurological and other disorders. However, the mechanism of ferroptosis in oligodendrocytes is unclear. We tested the susceptibility of MO3.13 cel
Externí odkaz:
https://doaj.org/article/c071cc546b414b289b54f1b4ee2a63db
Autor:
Snezana Milutinovic, Susanne Heynen-Genel, Elizabeth Chao, Antimone Dewing, Ricardo Solano, Loribelle Milan, Nikki Barron, Min He, Paul W Diaz, Shu-ichi Matsuzawa, John C Reed, Christian A Hassig
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0152692 (2016)
Cardiac glycosides (CGs), inhibitors of Na+/K+-ATPase (NKA), used clinically to treat heart failure, have garnered recent attention as potential anti-cancer and anti-viral agents. A high-throughput phenotypic screen designed to identify modulators of
Externí odkaz:
https://doaj.org/article/a364f22c4b134ec388b740ffc3d32178
Autor:
Kate Welsh, Snezana Milutinovic, Robert J Ardecky, Marcos Gonzalez-Lopez, Santhi Reddy Ganji, Peter Teriete, Darren Finlay, Stefan Riedl, Shu-Ichi Matsuzawa, Clemencia Pinilla, Richard Houghten, Kristiina Vuori, John C Reed, Nicholas D P Cosford
Publikováno v:
PLoS ONE, Vol 11, Iss 9, p e0161952 (2016)
Members of the Inhibitor of APoptosis (IAP) protein family suppress apoptosis within tumor cells, particularly in the context of immune cell-mediated killing by the tumor necrosis factor (TNF) superfamily cytokines. Most IAPs are opposed endogenously
Externí odkaz:
https://doaj.org/article/586e88ab700843089041a6fb4004bf01
Autor:
Teruki Yanagi, Kiyoshi Tachikawa, Rachel Wilkie-Grantham, Asami Hishiki, Ko Nagai, Ellen Toyonaga, Pad Chivukula, Shu-ichi Matsuzawa
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 5, Iss C (2016)
PCTAIRE1/CDK16/PCTK1 plays critical roles in cancer cell proliferation and antiapoptosis. To advance our previously published in vitro results with PCTAIRE1 silencing, we examined the in vivo therapeutic potential of this approach by using small inte
Externí odkaz:
https://doaj.org/article/68c6208c85b942e78aaeae5920fa4f0c
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0119404 (2015)
While PCTAIRE1/PCTK1/Cdk16 is overexpressed in malignant cells and is crucial in tumorigenesis, its function in apoptosis remains unclear. Here we investigated the role of PCTAIRE1 in apoptosis, especially in the extrinsic cell death pathway. Gene-kn
Externí odkaz:
https://doaj.org/article/2643cf30b2564a7a8bd5b352df166136
Transcription Factor ATF4 Induces NLRP1 Inflammasome Expression during Endoplasmic Reticulum Stress.
Autor:
Andrea D'Osualdo, Veronica G Anania, Kebing Yu, Jennie R Lill, Randal J Kaufman, Shu-ichi Matsuzawa, John C Reed
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0130635 (2015)
Perturbation of endoplasmic reticulum (ER) homeostasis triggers the ER stress response (also known as Unfolded Protein Response), a hallmark of many pathological disorders. However the connection between ER stress and inflammation remains largely une
Externí odkaz:
https://doaj.org/article/84d3426594a842108800d971428bf5da