Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Shu-Hui C. Yen"'
Publikováno v:
Frontiers in Aging Neuroscience, Vol 6 (2014)
Abnormal accumulation of filamentous α-synuclein (α-syn) in neurons, regarded as Lewy bodies(LBs), are a hallmark of Parkinson disease (PD). Although the exact mechanism(s) underlying LBs formation remains unknown, autophagy and ER stress response
Externí odkaz:
https://doaj.org/article/56eea4c4af1142989d7c4c75c8f62735
Autor:
Shu Hui C. Yen, Joseph E. Parisi, Naomi Kouri, Zeshan Ahmed, Kenichi Oshima, Dennis W. Dickson, Melissa E. Murray, Makio Takahashi
Publikováno v:
Acta Neuropathologica. 125:741-752
Corticobasal degeneration (CBD) is a disorder affecting cognition and movement due to a progressive neurodegeneration associated with distinctive neuropathologic features, including abnormal phosphorylated tau protein in neurons and glia in cortex, b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cce0e4cd6fd7a62d21b0ab27ff747792
https://doi.org/10.1007/s00401-013-1087-8
https://doi.org/10.1007/s00401-013-1087-8
Publikováno v:
Journal of Neuropathology & Experimental Neurology. 67:1084-1096
Filamentous alpha-synuclein (alpha-syn) aggregates form Lewy bodies (LBs), the neuropathologic hallmarks of Parkinson disease and related alpha-synucleinopathies. To model Lewy body-associated neurodegeneration, we generated transfectant 3D5 of human
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d45689cdfd1ab06a6df2cabb36a2f94
https://doi.org/10.1097/nen.0b013e31818c3618
https://doi.org/10.1097/nen.0b013e31818c3618
Autor:
Jennifer Hussey, Shu Hui C. Yen, Samuel Yen, Matthew J. Farrer, Colin Easson, John Hardy, Nitin D. Mehta, Li Wen Ko
Publikováno v:
Journal of Neurochemistry. 75:2546-2554
Linkage of alpha-synuclein (alpha-SN) mutations to familial Parkinson's disease (PD) and presence of alpha-SN as a major constituent of Lewy body in both sporadic and familial PD implicate alpha-SN abnormality in PD pathogenesis. Here we demonstrate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f17cc91271779583a6a774dd255e0738
https://doi.org/10.1046/j.1471-4159.2000.0752546.x
https://doi.org/10.1046/j.1471-4159.2000.0752546.x
Publikováno v:
Journal of Neurochemistry. 62:1055-1061
A synthetic peptide corresponding to residues 226-240 (E9 peptide) of human tau, which contains an Lys-Ser-Pro motif, was used to raise a polyclonal antibody. The antibody, E9, was 10-fold less reactive with phospho-E9 peptide than with native E9 pep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa644e93746afc19984b4eaa1b3e62b3
https://doi.org/10.1046/j.1471-4159.1994.62031055.x
https://doi.org/10.1046/j.1471-4159.1994.62031055.x
Autor:
Makio Takahashi, Shu Hui C. Yen, Jayanarayan Kulathingal, Li Wen Ko, Daniel Sevlever, Peizhou Jiang
Publikováno v:
European Journal of Neuroscience. 26:863-874
Intracellular accumulation of alpha-synuclein (alpha-Syn) as filamentous aggregates is a pathological feature shared by Parkinson's disease, dementia with Lewy bodies and multiple system atrophy, referred to as synucleinopathies. To understand the me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dcd6c647ab93f79416078ea97b9ef8d0
https://doi.org/10.1111/j.1460-9568.2007.05736.x
https://doi.org/10.1111/j.1460-9568.2007.05736.x
Autor:
Shu‐Hui C. Yen, Bridget Shafit-Zagardo, Wan‐Kyng ‐K Liu, Yvonne Kress, Joanna S. Albala, Karen M. Weidenheim
Publikováno v:
Journal of Neurochemistry. 64:2480-2490
Microtubule-associated protein-2 (MAP-2) functions to maintain neuronal morphology by promoting the assembly of microtubules. MAP-2c is an alternately spliced form of MAP-2, containing the first 151 amino acids of high-molecular-weight (HMW) MAP-2 jo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c07056bc1ccac444cfaf0bbaf011ad84
https://doi.org/10.1046/j.1471-4159.1995.64062480.x
https://doi.org/10.1046/j.1471-4159.1995.64062480.x
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 7 (2013)
Frontiers in Cellular Neuroscience
Frontiers in Cellular Neuroscience
The formation of Lewy bodies containing α-synuclein (α-syn), prominent loss of dopaminergic neurons and dopamine (DA) deficiency in substantia nigra and striatum are histopathological and biochemical hallmarks of Parkinson’s disease (PD). Multipl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b74024fc4f8b9e95db2a6b56de307b1
Publikováno v:
Neuropathology. 15:103-107
The presentation and distribution of neurofibrillary tangles (NFT), neuropil thread-like structures (T-LS) and smaller structures (dots) in the spinal cord of two patients with progressive supranuclear palsy (PSP) is discussed. Monoclonal antibodies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::40f6e3593037173297e253fb8458e6ee
https://doi.org/10.1111/j.1440-1789.1995.tb00250.x
https://doi.org/10.1111/j.1440-1789.1995.tb00250.x
Autor:
Ming Gan, Monica Castanedes-Casey, Shu Hui C. Yen, Dennis W. Dickson, Abdul Shukkur Ebrahim, Peizhou Jiang
Publikováno v:
Neurobiology of aging. 34(5)
Neuronal inclusions of α-synuclein (α-syn), termed Lewy bodies, are a hallmark of Parkinson disease (PD). Increased α-syn levels can occur in brains of aging human and neurotoxin-treated mice. Because previous studies have shown increased brain la
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acf640f8f78042ce5340c81d31881d6e
https://pubmed.ncbi.nlm.nih.gov/23200460
https://pubmed.ncbi.nlm.nih.gov/23200460