Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Shu-Hai Lin"'
Autor:
Junjia Liu, Xinyi Lu, Siyu Zeng, Rong Fu, Xindong Wang, Lingtao Luo, Ting Huang, Xusheng Deng, Hualei Zheng, Shaoqian Ma, Dan Ning, Lili Zong, Shu-Hai Lin, Yongyou Zhang
Publikováno v:
Redox Biology, Vol 71, Iss , Pp 103118- (2024)
The induction of ferroptosis is promising for cancer therapy. However, the mechanisms enabling cancer cells to evade ferroptosis, particularly in low-cystine environments, remain elusive. Our study delves into the intricate regulatory mechanisms of A
Externí odkaz:
https://doaj.org/article/838f9b3cff53424b8a47bc84edd51b3f
Autor:
Mingming Sun, Leilei Li, Yujia Niu, Yingzhi Wang, Qi Yan, Fei Xie, Yaya Qiao, Jiaqi Song, Huanran Sun, Zhen Li, Sizhen Lai, Hongkai Chang, Han Zhang, Jiyan Wang, Chenxin Yang, Huifang Zhao, Junzhen Tan, Yanping Li, Shuangping Liu, Bin Lu, Min Liu, Guangyao Kong, Yujun Zhao, Chunze Zhang, Shu-Hai Lin, Cheng Luo, Shuai Zhang, Changliang Shan
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 13, Iss 1, Pp 157-173 (2023)
Metabolic reprogramming is a hallmark of cancer, including lung cancer. However, the exact underlying mechanism and therapeutic potential are largely unknown. Here we report that protein arginine methyltransferase 6 (PRMT6) is highly expressed in lun
Externí odkaz:
https://doaj.org/article/36c8e8bd351c4e309e5b7c65ea0fc457
Autor:
Panrao Liu, Ning Tang, Chunchun Meng, Yuncong Yin, Xusheng Qiu, Lei Tan, Yingjie Sun, Cuiping Song, Weiwei Liu, Ying Liao, Shu-Hai Lin, Chan Ding
Publikováno v:
Virulence, Vol 13, Iss 1, Pp 1407-1422 (2022)
As obligate intracellular parasites, viruses rely completely on host metabolic machinery and hijack host nutrients for viral replication. Newcastle disease virus (NDV) causes acute, highly contagious avian disease and functions as an oncolytic agent.
Externí odkaz:
https://doaj.org/article/dd76011a2b40479a806ef509837f745b
Autor:
Buyun Dang, Qingxiang Gao, Lishan Zhang, Jia Zhang, Hanyi Cai, Yanhui Zhu, Qiumei Zhong, Junqiao Liu, Yujia Niu, Kairui Mao, Nengming Xiao, Wen-Hsien Liu, Shu-hai Lin, Jialiang Huang, Stanley Ching-Cheng Huang, Ping-Chih Ho, Shih-Chin Cheng
Publikováno v:
Cell Reports, Vol 42, Iss 5, Pp 112471- (2023)
Summary: T helper type 2 (Th2) cytokine-activated M2 macrophages contribute to inflammation resolution and wound healing. This study shows that IL-4-primed macrophages exhibit a stronger response to lipopolysaccharide stimulation while maintaining M2
Externí odkaz:
https://doaj.org/article/2a8072e0bc374cf9b03979d9c2fbc8c9
Autor:
Xi-Qiu Xu, Tongran Xu, Wenting Ji, Chong Wang, Yujie Ren, Xiaobei Xiong, Xi Zhou, Shu-Hai Lin, Yi Xu, Yang Qiu
Publikováno v:
mBio, Vol 14, Iss 1 (2023)
ABSTRACT Herpes simplex virus 1 (HSV-1) is a DNA virus belonging to the family Herpesviridae. HSV-1 infection causes severe neurological disease in the central nervous system (CNS), including encephalitis. Ferroptosis is a nonapoptotic form of progra
Externí odkaz:
https://doaj.org/article/32dbc437b3784209807bb1fcfd577923
Autor:
Qiubin Lin, Li Rong, Xian Jia, Renhao Li, Bin Yu, Jingchu Hu, Xiao Luo, S. R. Badea, Chen Xu, Guofeng Fu, Kejiong Lai, Ming-chun Lee, Baozhong Zhang, Huarui Gong, Nan Zhou, Xiao Lei Chen, Shu-hai Lin, Guo Fu, Jian-Dong Huang
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Cancer metastasis is one of the major causes of cancer related deaths and there is an urgent need to find more clinically effective metastasis targeting agents. Here, the authors show that Salmonella YB1 inhibits metastasis in multiple mouse models o
Externí odkaz:
https://doaj.org/article/23602877f25040a79dc5d8fa00d14efc
Autor:
Zhu Yang, Dianqiang Yang, Fancheng Tan, Chi Wai Wong, James Y. Yang, Da Zhou, Zongwei Cai, Shu-Hai Lin
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
The prevalence of diabetes mellitus has been increasing for decades worldwide. To develop safe and potent therapeutics, animal models contribute a lot to the studies of the mechanisms underlying its pathogenesis. Dietary induction using is a well-acc
Externí odkaz:
https://doaj.org/article/66d83047092f4d968fbe4929d117f585
Autor:
Nan Jin, Aiwei Bi, Xiaojing Lan, Jun Xu, Xiaomin Wang, Yingluo Liu, Ting Wang, Shuai Tang, Hanlin Zeng, Ziqi Chen, Minjia Tan, Jing Ai, Hua Xie, Tao Zhang, Dandan Liu, Ruimin Huang, Yue Song, Elaine Lai-Han Leung, Xiaojun Yao, Jian Ding, Meiyu Geng, Shu-Hai Lin, Min Huang
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Cancer subtypes may have distinct metabolic vulnerabilities that can be exploited for therapeutic interventions. Here, the authors show that in lung cancer, genetic activation of distinct oncogenic receptor tyrosine kinases results in unique metaboli
Externí odkaz:
https://doaj.org/article/9657645615f24b61be1f24096a3bc13c
Autor:
Yuetong Wang, Jian Zhang, Shengxiang Ren, Dan Sun, Hsin-Yi Huang, Hua Wang, Yujuan Jin, Fuming Li, Chao Zheng, Liu Yang, Lei Deng, Zhonglin Jiang, Tao Jiang, Xiangkun Han, Shenda Hou, Chenchen Guo, Fei Li, Dong Gao, Jun Qin, Daming Gao, Luonan Chen, Shu-Hai Lin, Kwok-Kin Wong, Cheng Li, Liang Hu, Caicun Zhou, Hongbin Ji
Publikováno v:
Cell Reports, Vol 28, Iss 2, Pp 512-525.e6 (2019)
Summary: Drug resistance is a significant hindrance to effective cancer treatment. Although resistance mechanisms of epidermal growth factor receptor (EGFR) mutant cancer cells to lethal EGFR tyrosine kinase inhibitors (TKI) treatment have been inves
Externí odkaz:
https://doaj.org/article/23f472c261ea484485e16751e7f20231
Autor:
Xue Gao, Shu-Hai Lin, Feng Ren, Jin-Tao Li, Jia-Jia Chen, Chuan-Bo Yao, Hong-Bin Yang, Shu-Xia Jiang, Guo-Quan Yan, Di Wang, Yi Wang, Ying Liu, Zongwei Cai, Ying-Ying Xu, Jing Chen, Wenqiang Yu, Peng-Yuan Yang, Qun-Ying Lei
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
Cancer cells under stress use acetate to maintain the acetyl-CoA pool and fuel lipid biosynthesis. Here, the authors show that acetate also promotes de novo lipid synthesis by increasing histone acetylation at the promoters of lipogenic enzymes ACACA
Externí odkaz:
https://doaj.org/article/b8194c2aa98945ec80fb6bb93952191d