Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Shu-Fu Wang"'
Autor:
Shu-Fu Wang, Peng-Cheng Lv, Mingguo Jiang, Hai-Liang Zhu, Xiao-Wei Yu, Aimin Lu, Yong Yin, Lifang Yang, Meng-Yue Zhao, Chetan B. Sangani
Publikováno v:
Bioorganic & Medicinal Chemistry. 23:46-54
Many reports implied that the BRAF serine/threonine kinase was mutated in various types of human tumors, which were related with cell growth, survival and differentiation. To provide new therapeutic opportunities, a series of novel 4,5-dihydro-1H-pyr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1f395582fb5e5ec102fd8f870cdc7fd4
https://doi.org/10.1016/j.bmc.2014.11.029
https://doi.org/10.1016/j.bmc.2014.11.029
Autor:
Meng-Yue Zhao, Ya-Liang Zhang, Shu-Fu Wang, Jigar A. Makawana, Hai-Liang Zhu, Yin-Ling Zhu, Ping-Ting Zhu, Peng-Cheng Lv
Publikováno v:
Bioorganic & Medicinal Chemistry. 22:6201-6208
A series of novel 5-phenyl-1H-pyrazole derivatives (5 a-5 u) containing niacinamide moiety were synthesized and evaluated for biological activity as potential BRAF(V600E) inhibitors. Among them, compound 5h exhibited the most potent inhibitory activi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c7cd67f48039dec7b9e40794cedf713
https://doi.org/10.1016/j.bmc.2014.08.029
https://doi.org/10.1016/j.bmc.2014.08.029
Autor:
Meng-Yue Zhao, Ya-Liang Zhang, Shu-Fu Wang, Peng-Cheng Lv, Hai-Liang Zhu, Bao-Zhong Wang, Yong Yin, Shan-Wei Mi
Publikováno v:
European journal of medicinal chemistry. 93
A series of novel 5-phenyl-1H-pyrazol derivatives (5a–5x) containing cinnamamide moiety were synthesized and their biological activities as potential tubulin polymerization inhibitors were evaluated. Among them, compound 5j exhibited the most poten
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::705a3e5c8817e6c2b42b3de6ddb0a49d
https://pubmed.ncbi.nlm.nih.gov/25703297
https://pubmed.ncbi.nlm.nih.gov/25703297
Autor:
Meng-Yue, Zhao, Yong, Yin, Xiao-Wei, Yu, Chetan B, Sangani, Shu-Fu, Wang, Ai-Min, Lu, Li-Fang, Yang, Peng-Cheng, Lv, Ming-Guo, Jiang, Hai-Liang, Zhu
Publikováno v:
Bioorganicmedicinal chemistry. 23(1)
Many reports implied that the BRAF serine/threonine kinase was mutated in various types of human tumors, which were related with cell growth, survival and differentiation. To provide new therapeutic opportunities, a series of novel 4,5-dihydro-1H-pyr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::743a3be7751b1669ee8399e96824f927
https://pubmed.ncbi.nlm.nih.gov/25496804
https://pubmed.ncbi.nlm.nih.gov/25496804
Autor:
Jing-Jun Dong, Shu-Fu Wang, Xin Zhao, Cui-Yun Li, Han-Yue Qiu, Hai-Liang Zhu, Meng-Yue Zhao, Qing-Shan Li
Publikováno v:
Organicbiomolecular chemistry. 11(37)
The RAF-MEK-ERK cascade appears to be intimately involved in the regulation of cell cycle progression and apoptosis. The BRAF(V600E) mutant results in constitutive activation of the ERK pathway, which can lead to cellular growth dysregulation. A seri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fca06028d531b259e8220dce00adf9f9
https://pubmed.ncbi.nlm.nih.gov/23942809
https://pubmed.ncbi.nlm.nih.gov/23942809
Autor:
Shu-Fu Wang, Qing-Shan Li, Yong-Hua Yang, Zhipeng Liu, Xiao-Ming Wang, Meng-Yue Zhao, Hai-Liang Zhu, Jing-Jun Dong
Publikováno v:
European journal of medicinal chemistry. 70
The kinesin spindle protein (KSP) is involved in the formation of bipolar mitotic spindle during cell division and it becomes a new target to overcome the neurotoxicity of MTs inhibitors. A series of flavone and isoflavone derivatives (1a–7c) have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1d825d88553580c0d735e2bde514df6
https://pubmed.ncbi.nlm.nih.gov/24184776
https://pubmed.ncbi.nlm.nih.gov/24184776