Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Shu-Fen Wen"'
Autor:
Stephen R. Indelicato, Shu Fen Wen, Jeremy Shinoda, I A Atencio, Alan P. Venook, Daniel C. Maneval, Mary Lynn Musco, Robert S. Warren, Beth Hutchins, Ronald Bordens, Grace Michael, M Fritz, Karen Kolz, Sheila Jacobs, Jo Ann Horowitz
Publikováno v:
Cancer Gene Therapy. 13:169-181
The major focus of intrahepatic arterial (IHA) administration of adenoviruses (Ad) has been on safety. Currently, there is little published data on the biological responses to Ad when administered via this route. As part of a Phase I study, we evalua
Autor:
Beth Hutchins, Vellekamp Gary J, Suganto Sutjipto, Todd Machemer, Heidrun Engler, Drake LaFace, Elena Brin, Susan Cannon-Carlson, Douglas Cornell, Mark Horn, Marcio Voloch, Thomas Schluep, Van Tsai, Nico van Rooijen, Dan Maneval, Shu Fen Wen, Seoju Lee, Sundari Ravindran
Publikováno v:
Molecular Therapy. 12:254-263
Intravascular administration of recombinant adenovirus (rAd) in cancer patients has been well tolerated. However, dose-limiting hemodynamic responses associated with suppression of cardiac output have been observed at doses of 7.5 x 10(13) particles.
Autor:
Van Tsai, Heidrun Engler, Murali Ramachandra, Todd Machemer, Erlinda Quijano, Robert O. Ralston, Jennifer Philopena, Shu-Fen Wen
Publikováno v:
Virology. 328(1):52-61
Replication competent adenoviruses with various E1 modifications designed to restrict their replication to tumor cells are being evaluated as oncolytic agents in clinical trials. In mouse models, we observed that such oncolytic adenoviruses showed gr
Autor:
Shu Fen Wen, Drake LaFace, Jennifer Chavez, Kevin Mills, Mei Vaillancourt, Dan Maneval, Phyllis I. Warkentin, Cheryl Leutzinger, Janae E. Lehman, S. N. Robinson, James E. Talmadge, Janos Sumegi, Catherine B. Talmadge, Sarah Neugebauer, Linda S. Kelsey, Manabu Hirai, Robert G. Johnson
Publikováno v:
Cancer Gene Therapy. 8:936-947
Co-incubation of a replication-deficient, recombinant adenovirus carrying the wild-type p53 gene (rAd-p53) and hematopoietic stem cell (HSC) products from patients with breast cancer can significantly reduce tumor cell contamination. Whereas this app
Autor:
Barry J. Sugarman, John A. Howe, Machemer T, Nodelman M, Daniel C. Maneval, Demers Gw, Shu Fen Wen, Nagabhushan Tl, Wills Ken N, Duane E. Johnson, Heidrun Engler, Shinoda J, Beltran J, Iqbal Ahmed Cm
Publikováno v:
Cancer Gene Therapy. 8:788-795
A recombinant adenovirus expressing human interferon alpha2b driven by the cytomegalovirus promoter, IACB, was shown to produce and secrete biologically active protein in vitro and in vivo. Intravenous administration of IACB in Buffalo rats resulted
Autor:
Jenny Avanzini, Shu Fen Wen, Mei Vaillancourt, Isabella A. Atencio, Duane E. Johnson, Robert O. Ralston, Wills Ken N, Saskia Neuteboom, Jennifer Philopena, Suganto Sutjipto, Anne Phelan
Publikováno v:
Journal of Virology. 75:8733-8741
In vitro experiments have demonstrated intercellular trafficking of the VP22 tegument protein of herpes simplex virus type 1 from infected cells to neighboring cells, which internalize VP22 and transport it to the nucleus. VP22 also can mediate inter
Autor:
Amena Rahman, Van T. Tsai, Paul W. Shabram, Rob Ralston, Drake LaFace, Dan Maneval, Ann M. Goudreau, Jeremy Shinoda, Shu Fen Wen, Murali Ramachandra
Publikováno v:
Molecular Therapy. 3:768-778
Recombinant adenoviral (rAd) vectors are capable of mediating high-efficiency gene transfer in vivo. Under conditions requiring systemic administration, however, the use of rAd vectors can be problematic due to the presence of circulating anti-adenov
Autor:
Loretta L. Nielsen, Lei Xie, Ruth DiGiacomo, Maya Gurnani, Suxing Liu, Matthew McDonald, Stephen R. Indelicato, Bin Shi, Shu Fen Wen, Alice Chang, Beth Hutchins
Publikováno v:
Cancer Gene Therapy. 7:1469-1480
SCH58500 (ACN53) is a replication-deficient, type 5 adenovirus (Ad) expressing human wild-type p53 tumor suppressor. It is currently undergoing clinical trials as a cancer therapeutic. Many SCH58500 clinical trials incorporate an arm comparing tradit
Autor:
Suzie H. Pun, Nathalie C. Bellocq, Thomas Schluep, Greg Jensen, Todd Machemer, Erlinda Quijano, Jeremy D. Heidel, Shu-Fen Wen, Heidrun Engler, Mark E. Davis, Aijie Liu
Publikováno v:
Bioconjugate chemistry. 15(4)
Linear and branched poly(ethylenimines), lPEI and bPEI, respectively, grafted with beta-cyclodextrin are prepared to give CD-lPEI and CD-bPEI, respectively, and are investigated as in vitro and in vivo nonviral gene delivery agents. The in vitro toxi
Autor:
G William, Demers, Duane E, Johnson, Van, Tsai, Shu-Fen, Wen, Erlinda, Quijano, Todd, Machemer, Jennifer, Philopena, Murali, Ramachandra, John A, Howe, Paul, Shabram, Robert, Ralston, Heidrun, Engler
Publikováno v:
Cancer research. 63(14)
Central to the development of oncolytic virotherapies for cancer will be a better understanding of the parameters that influence the outcome of virotherapy to treat disseminated cancer by i.v. administration versus regional disease by local treatment