Zobrazeno 1 - 10
of 94
pro vyhledávání: '"Shu Zhuo"'
Publikováno v:
Cell Discovery, Vol 8, Iss 1, Pp 1-4 (2022)
Externí odkaz:
https://doaj.org/article/b792adace1244638b3a5eb1894be5ff9
Autor:
Zhongbo Li, Peng Su, Yinlu Ding, Honglei Gao, Huijie Yang, Xin Li, Xiao Yang, Yan Xia, Chenmiao Zhang, Mingxi Fu, Dehai Wang, Ye Zhang, Shu Zhuo, Jian Zhu, Ting Zhuang
Publikováno v:
Cell Communication and Signaling, Vol 20, Iss 1, Pp 1-18 (2022)
Abstract Background Triple negative breast cancer (TNBC) is one of the most lethal breast cancer subtypes. Due to a lack of effective therapeutic targets, chemotherapy is still the main medical treatment for TNBC patients. Thus, it is important and n
Externí odkaz:
https://doaj.org/article/21ace992caea4ac187fbf04fedb51950
Autor:
Xu Li, Shu Zhuo, Ting Zhuang, Yong Suk Cho, Guojin Wu, Yuchen Liu, Kun Mu, Kai Zhang, Peng Su, Yingzi Yang, Cheng Cheng Zhang, Jian Zhu, Jin Jiang
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Recent studies have reported that oncoprotein YAP can function as tumour suppressor in certain contexts. Here the authors show that inhibition of Hippo signalling or YAP activation blocks ERα transcriptional program and ER + breast cancer growth and
Externí odkaz:
https://doaj.org/article/903d62df88104f45a8c7b8a973802858
Autor:
Xin Li, Zhiguo Niu, Chen Sun, Shu Zhuo, Huijie Yang, Xiao Yang, Yun Liu, Cheng Yan, Zhongbo Li, Qi Cao, Guimei Ji, Yinlu Ding, Ting Zhuang, Jian Zhu
Publikováno v:
Cell Death and Disease, Vol 13, Iss 2, Pp 1-11 (2022)
Abstract The tumor suppressor P53 plays critical role in preventing cancer. P53 is rarely mutated and remains functional in luminal-type breast cancer(1). According to current knowledge, wild-type P53 function is tightly controlled by posttranslation
Externí odkaz:
https://doaj.org/article/11eb63a714f44e6b993dbf90a27d9267
Autor:
Na Li, Ting Wang, Zongmeng Li, Xiaoli Ye, Bo Deng, Shu Zhuo, Pengle Yao, Mengmei Yang, Hong Mei, Xiaofang Chen, Tengfei Zhu, Shiting Chen, Hui Wang, Jiming Wang, Yingying Le
Publikováno v:
Cancer Biology & Medicine, Vol 16, Iss 2, Pp 220-233 (2019)
Objective Heat shock factor 1 (HSF1), a transcriptional regulator of heat shock proteins (HSPs), is an attractive therapeutic target for cancer. However, only a few HSF1 inhibitors have been identified so far.Methods The mRNA and protein levels of HS
Externí odkaz:
https://doaj.org/article/0e4a998a23ba4ec792d341bdc55314be
Publikováno v:
In Marine Geology October 2022 452
Publikováno v:
The EMBO journalReferences.
Hippo signaling restricts tumor growth by inhibiting the oncogenic potential of YAP/TAZ-TEAD transcriptional complex. Here we uncover a context-dependent tumor suppressor function of YAP in androgen receptor (AR) positive prostate cancer (PCa) and sh
Autor:
Shuxiao Dong, Xin Li, Shu Zhuo, Jianhui Gao, Huijie Yang, Yinlu Ding, Wenrong Xu, Jian Zhu, Zhiguo Niu, Hui Qian, Qingsong Huang, Ting Zhuang
Publikováno v:
Journal of Cancer
Chemotherapy is widely used in a variety of solid tumors, such as lung cancer, gastric cancer and breast cancer. The genotoxic drugs, such as cisplatin, suppress cancer progression either by inhibition cell proliferation or facilitating apoptosis. Ho
Autor:
Bo Yang, Yuanyuan Jia, Yumin Meng, Ying Xue, Kefang Liu, Yan Li, Shichao Liu, Xiaoxiong Li, Kaige Cui, Lina Shang, Tianyou Cheng, Zhichao Zhang, Yingxiang Hou, Xiaozhu Yang, Hong Yan, Liqiang Duan, Zhou Tong, Changxin Wu, Zhida Liu, Shan Gao, Shu Zhuo, Weijin Huang, George Fu Gao, Jianxun Qi, Guijun Shang
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance We here established the interaction between PDZ binding motif (PBM) at the C terminal of ACE2 and PDZ domain of sorting nexin 27 (SNX27) and solved the crystal structure of ACE2-PBM/SNX27-PDZ complex. Together with retromer complex, SNX2
Autor:
Xu, Li, Shu, Zhuo, Ting, Zhuang, Yong Suk, Cho, Guojin, Wu, Yuchen, Liu, Kun, Mu, Kai, Zhang, Peng, Su, Yingzi, Yang, Cheng Cheng, Zhang, Jian, Zhu, Jin, Jiang
Publikováno v:
Nature communications. 13(1)
Hippo signaling restricts tissue growth by inhibiting the transcriptional effector YAP. Here we uncover a role of Hippo signaling and a tumor suppressor function of YAP in estrogen receptor positive (ER